Relationship between triglyceride-glucose index and intravenous thrombolysis outcomes for acute ischemic stroke

Selcen Duran; Aysu Yetiş

Makale detayları

Relationship between triglyceride-glucose index and intravenous thrombolysis outcomes for acute ischemic stroke

Yazarlar:

Selcen Duran | Aysu Yetiş

Yayıncı:

MediHealth Academy Yayıncılık

Ana Başlıklar:

Nöroloji ve Nöromüsküler Hastalıklar

Dergi:

Journal of Health Sciences and Medicine Vol.8 Issue 1, pp.52-56

Belge Tipi:

Makale

Yayın Tarihi:

12/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001338913

pISSN:

2636-8579

Anahtar kelimeler:

Özet:

 Aims: The aim of this study was to investigate the effect of triglyceride glucose index, a marker of insulin resistance, on early neurological deterioration END, development of intracerebral hemorrhage and hemorrhagic transformation and mortality in patients receiving intravenous thrombolytic therapy for acute ischemic stroke. Methods: This retrospective study included 71 patients with acute ischemic stroke who received intravenous tissue plasminogen activator. Demographic data, clinical and radiological findings, fasting glucose and lipid profile, END, hemorrhage development and mortality rates were analyzed. We also calculated the triglyceride glucose TyG index and examined its correlation with early neurological deterioration, hemorrhage development and mortality. Results: The median age was 74 years 41-88, with a female predominance of 54.9. The incidence of intracerebral hemorrhage was 9.6, while END occurred in 39.6 of cases, and the 30-day mortality rate was 28.2. The mean TyG index was 7.8 2.8-27.6. The receiver operating characteristic curve analysis indicated that the TyG index predicted mortality with an area under the curve of 84.4, a sensitivity of 85, and a specificity of 82.35 in patients with a TyG index above 10.01 p0.01. According to univariate analyse, the admission NIHSS score was associated with a 1.46-fold increase in the odds of mortality odds ratio OR: 1.459, while a TyG index greater than 10.01 was associated with a 1763.9-fold increase in mortality risk OR: 1763.9 p0.005; p0.009, respectively. Patients with higher TyG index also exhibited significantly increased rates of mortality and END p0.001 for both. There was no association between development of hemorrhage and TyG index p0.05. Conclusion: This study supports that a high TyG index is associated with END and mortality but not with the development of hemorrhage. Multicenter studies with larger sample size are needed.

 Aims: The aim of this study was to investigate the effect of triglyceride glucose index, a marker of insulin resistance, on early neurological deterioration END, development of intracerebral hemorrhage and hemorrhagic transformation and mortality in patients receiving intravenous thrombolytic therapy for acute ischemic stroke. Methods: This retrospective study included 71 patients with acute ischemic stroke who received intravenous tissue plasminogen activator. Demographic data, clinical and radiological findings, fasting glucose and lipid profile, END, hemorrhage development and mortality rates were analyzed. We also calculated the triglyceride glucose TyG index and examined its correlation with early neurological deterioration, hemorrhage development and mortality. Results: The median age was 74 years 41-88, with a female predominance of 54.9. The incidence of intracerebral hemorrhage was 9.6, while END occurred in 39.6 of cases, and the 30-day mortality rate was 28.2. The mean TyG index was 7.8 2.8-27.6. The receiver operating characteristic curve analysis indicated that the TyG index predicted mortality with an area under the curve of 84.4, a sensitivity of 85, and a specificity of 82.35 in patients with a TyG index above 10.01 p0.01. According to univariate analyse, the admission NIHSS score was associated with a 1.46-fold increase in the odds of mortality odds ratio OR: 1.459, while a TyG index greater than 10.01 was associated with a 1763.9-fold increase in mortality risk OR: 1763.9 p0.005; p0.009, respectively. Patients with higher TyG index also exhibited significantly increased rates of mortality and END p0.001 for both. There was no association between development of hemorrhage and TyG index p0.05. Conclusion: This study supports that a high TyG index is associated with END and mortality but not with the development of hemorrhage. Multicenter studies with larger sample size are needed.

 Aims: The aim of this study was to investigate the effect of triglyceride glucose index, a marker of insulin resistance, on early neurological deterioration END, development of intracerebral hemorrhage and hemorrhagic transformation and mortality in patients receiving intravenous thrombolytic therapy for acute ischemic stroke. Methods: This retrospective study included 71 patients with acute ischemic stroke who received intravenous tissue plasminogen activator. Demographic data, clinical and radiological findings, fasting glucose and lipid profile, END, hemorrhage development and mortality rates were analyzed. We also calculated the triglyceride glucose TyG index and examined its correlation with early neurological deterioration, hemorrhage development and mortality. Results: The median age was 74 years 41-88, with a female predominance of 54.9. The incidence of intracerebral hemorrhage was 9.6, while END occurred in 39.6 of cases, and the 30-day mortality rate was 28.2. The mean TyG index was 7.8 2.8-27.6. The receiver operating characteristic curve analysis indicated that the TyG index predicted mortality with an area under the curve of 84.4, a sensitivity of 85, and a specificity of 82.35 in patients with a TyG index above 10.01 p0.01. According to univariate analyse, the admission NIHSS score was associated with a 1.46-fold increase in the odds of mortality odds ratio OR: 1.459, while a TyG index greater than 10.01 was associated with a 1763.9-fold increase in mortality risk OR: 1763.9 p0.005; p0.009, respectively. Patients with higher TyG index also exhibited significantly increased rates of mortality and END p0.001 for both. There was no association between development of hemorrhage and TyG index p0.05. Conclusion: This study supports that a high TyG index is associated with END and mortality but not with the development of hemorrhage. Multicenter studies with larger sample size are needed.

 Amaç: Bu çalışmanın amacı, akut iskemik inme nedeniyle intravenöz trombolitik tedavi alan hastalarda insülin direncinin bir belirteci olan trigliserit glukoz indeksinin erken nörolojik kötüleşme ENK, intraserebral kanama ve hemorajik transformasyon gelişimi ve mortalite üzerine etkisini araştırmaktır. Yöntem: Bu retrospektif çalışmaya akut iskemik inme nedeniyle intravenöz doku plazminojen aktivatörü IV tPA uygulanan 71 hasta dahil edildi. Demografik veriler, klinik ve radyolojik bulgular, açlık glukozu ve lipid profili, ENK, kanama gelişimi ve mortalite oranları analiz edildi. Trigliserid glukoz TyG indeksi hesaplanarak ve erken nörolojik bozulma, kanama gelişimi ve mortalite ile korelasyonu incelendi. Sonuç: Yaş ortancası 74 41-88 olup, 54.9u kadındı. İntraserebral hemoraji insidansı 9.6 iken, olguların 39.6sında ENK meydana geldi ve 30 günlük mortalite oranı 28.2 idi. Ortalama TyG indeksi 7.8 2.8-27.6 idi. ROC eğrisi analizi, TyG indeksinin 10.01in üzerinde olan hastalarda 84.4 eğri altında kalan alan, 85 duyarlılık ve 82.35 özgüllük ile mortaliteyi öngördüğünü göstermiştir p0.01. Tek değişkenli analize göre, başvuru NIHSS skoru mortalite olasılığında 1,46 kat artışla odds oranı OR: 1,459 ilişkiliyken, 10,01den büyük bir TyG indeksi mortalite riskinde 1763,9 kat artışla OR: 1763,9 ilişkiliydi sırasıyla p0,005; p0,009. TyG indeksi daha yüksek olan hastalarda da mortalite ve ENK oranlarında anlamlı artış görülmüştür her ikisi için de p0.001. Hemoraji gelişimi ile TyG indeksi arasında bir ilişki bulunmamıştır p0.05. Sonuç: Bu çalışma, yüksek TyG indeksinin ENK ve mortalite ile ilişkili olduğunu ancak kanama gelişimi ile ilişkili olmadığını desteklemektedir. Daha geniş örneklemli çok merkezli çalışmalara ihtiyaç vardır.

Makale detayları

Relationship between triglyceride-glucose index and intravenous thrombolysis outcomes for acute ischemic stroke

Yazarlar:

Selcen Duran | Aysu Yetiş

Yayıncı:

MediHealth Academy Yayıncılık

Ana Başlıklar:

Nöroloji ve Nöromüsküler Hastalıklar

Dergi:

Journal of Health Sciences and Medicine Vol.8 Issue 1, pp.52-56

Belge Tipi:

Makale

Yayın Tarihi:

12/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001338913

pISSN:

2636-8579

Triglyceride glucose index

insulin resistance

intravenous thrombolytic therapy

acute ischemic stroke

hemorrhagic transformationTrigliserid glikoz indeksi

insülin direnci

intravenöz trombolitik tedavi

akut iskemik inme

hemorajik transformasyon

Sayı

Makale detayları

Yazarlar: Selcen Duran | Aysu Yetiş

Yayıncı: MediHealth Academy Yayıncılık

Ana Başlıklar: Nöroloji ve Nöromüsküler Hastalıklar

Dergi: Journal of Health Sciences and Medicine Vol.8 Issue 1, pp.52-56

Belge Tipi: Makale

Yayın Tarihi: 12/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001338913

pISSN: 2636-8579

Sayı

Yazarlar:

Selcen Duran | Aysu Yetiş

Yayıncı:

MediHealth Academy Yayıncılık

Ana Başlıklar:

Nöroloji ve Nöromüsküler Hastalıklar

Dergi:

Journal of Health Sciences and Medicine Vol.8 Issue 1, pp.52-56

Belge Tipi:

Makale

Yayın Tarihi:

12/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001338913

pISSN:

2636-8579