Reminder Stress Application and the Effect of Gender on the Experimental Model in the Rat Post-Trauma Stress Disorder Model

Ertan Darıverenli; Pelin Akça; Furkan Öztekin; Elvan Hasan Yılmaz; Tuğba Çavuşoğlu

Makale detayları

Reminder Stress Application and the Effect of Gender on the Experimental Model in the Rat Post-Trauma Stress Disorder Model

Yazarlar:

Ertan Darıverenli | Pelin Akça | Furkan Öztekin | Elvan Hasan Yılmaz | Tuğba Çavuşoğlu

Yayıncı:

Manisa Celal Bayar University

Ana Başlıklar:

Klinik Tıp Bilimleri

Dergi:

Celal Bayar Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi Vol.11 Issue 1, pp.36-56

Belge Tipi:

Makale

Yayın Tarihi:

3/2024

Belge Dili:

Türkçe

Document ID (Org No.):

2001314103

pISSN:

2147-9607

Anahtar kelimeler:

Özet:

 In this study, it was aimed to evaluate the effect of gender factor and initial baseline test procedures on the results of the experimental model in the rat PTSD model created with stressreminder stress. As a result, in the light of the results resulting from the differences between the groups, it will be important that the rat model to be created in the PTSD models that we will use in future research will be more successful and that it will affect the results of future studies on this subject. Experimental animals were divided into 8 groups according to the study procedure and purpose. At the beginning of the procedure, behavioral tests were applied to the groups to be subjected to basal tests, and stress protocol was applied to the stress groups. At the end of the study, behavioral tests were performed on all animals. Behavioral tests were elevated plus maze and open field tests. The data were analyzed statistically. Although there were significant differences in some of the parameters of the groups at the end of the study in behavioral tests, when evaluated in total, there was no significant difference between the groups with and without baseline tests in behavioral tests, and between the groups of female and male rats.

 In this study, it was aimed to evaluate the effect of gender factor and initial baseline test procedures on the results of the experimental model in the rat PTSD model created with stressreminder stress. As a result, in the light of the results resulting from the differences between the groups, it will be important that the rat model to be created in the PTSD models that we will use in future research will be more successful and that it will affect the results of future studies on this subject. Experimental animals were divided into 8 groups according to the study procedure and purpose. At the beginning of the procedure, behavioral tests were applied to the groups to be subjected to basal tests, and stress protocol was applied to the stress groups. At the end of the study, behavioral tests were performed on all animals. Behavioral tests were elevated plus maze and open field tests. The data were analyzed statistically. Although there were significant differences in some of the parameters of the groups at the end of the study in behavioral tests, when evaluated in total, there was no significant difference between the groups with and without baseline tests in behavioral tests, and between the groups of female and male rats.

 In this study, it was aimed to evaluate the effect of gender factor and initial baseline test procedures on the results of the experimental model in the rat PTSD model created with stressreminder stress. As a result, in the light of the results resulting from the differences between the groups, it will be important that the rat model to be created in the PTSD models that we will use in future research will be more successful and that it will affect the results of future studies on this subject. Experimental animals were divided into 8 groups according to the study procedure and purpose. At the beginning of the procedure, behavioral tests were applied to the groups to be subjected to basal tests, and stress protocol was applied to the stress groups. At the end of the study, behavioral tests were performed on all animals. Behavioral tests were elevated plus maze and open field tests. The data were analyzed statistically. Although there were significant differences in some of the parameters of the groups at the end of the study in behavioral tests, when evaluated in total, there was no significant difference between the groups with and without baseline tests in behavioral tests, and between the groups of female and male rats.

 Öz Bu araştırmada streshatırlatıcı stres ile oluşturulan sıçan TSSB modelinde cinsiyet faktörünün ve başlangıçta yapılan bazal test prosedürlerinin deney modelinin sonuçlarına etkisinin değerlendirilmesi amaçlanmıştır. Bunun sonucunda gruplar arası farklılıklar sonucu oluşan sonuçlar ışığında daha sonraki araştırmalarda kullanacağımız TSSB modellerinde oluşturulacak sıçan modelinin daha başarılı olması ve bu konuda daha sonraları yapılması planlanan araştırmalardaki sonuçları etkilemesi açısından önemli olacaktır. Deney hayvanları çalışma prosedürü ve amacına göre 8 gruba ayrılmıştır. Hayvanların bazal testleri yapılacak gruplarına prosedürün başlangıcında davranış testleri, stres gruplarına stres protokolü uygulanmıştır. Çalışmanın sonunda hayvanların tümüne yüksek artı labirent ve açık alan testi olmak üzere davranış deneyleri yapılmıştır. Veriler istatistiksel olarak analiz edilmiştir. Davranış testlerinde grupların çalışma sonunda yapılan parametrelerinin bazılarında anlamlı farklılıklar görülmekle birlikte, total olarak değerlendirildiğinde davranış testlerinde bazal testleri yapılmış ve yapılmamış gruplar arasında ve dişi erkek sıçan grupları arasında anlamlı bir farklılık bulunmamıştır.

Makale detayları

Reminder Stress Application and the Effect of Gender on the Experimental Model in the Rat Post-Trauma Stress Disorder Model

Yazarlar:

Ertan Darıverenli | Pelin Akça | Furkan Öztekin | Elvan Hasan Yılmaz | Tuğba Çavuşoğlu

Yayıncı:

Manisa Celal Bayar University

Ana Başlıklar:

Klinik Tıp Bilimleri

Dergi:

Celal Bayar Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi Vol.11 Issue 1, pp.36-56

Belge Tipi:

Makale

Yayın Tarihi:

3/2024

Belge Dili:

Türkçe

Document ID (Org No.):

2001314103

pISSN:

2147-9607

post traumatic stress disorder

rat

gendertravma sonrası stres bozukluğu

sıçan

cinsiyet

Sayı

Makale detayları

Reminder Stress Application and the Effect of Gender on the Experimental Model in the Rat Post-Trauma Stress Disorder Model

Yazarlar: Ertan Darıverenli | Pelin Akça | Furkan Öztekin | Elvan Hasan Yılmaz | Tuğba Çavuşoğlu

Yayıncı: Manisa Celal Bayar University

Ana Başlıklar: Klinik Tıp Bilimleri

Dergi: Celal Bayar Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi Vol.11 Issue 1, pp.36-56

Belge Tipi: Makale

Yayın Tarihi: 3/2024

Belge Dili: Türkçe

Document ID (Org No.): 2001314103

pISSN: 2147-9607

post traumatic stress disorder

rat

gendertravma sonrası stres bozukluğu

sıçan

cinsiyet

Sayı

Yazarlar:

Ertan Darıverenli | Pelin Akça | Furkan Öztekin | Elvan Hasan Yılmaz | Tuğba Çavuşoğlu

Yayıncı:

Manisa Celal Bayar University

Ana Başlıklar:

Klinik Tıp Bilimleri

Dergi:

Celal Bayar Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi Vol.11 Issue 1, pp.36-56

Belge Tipi:

Makale

Yayın Tarihi:

3/2024

Belge Dili:

Türkçe

Document ID (Org No.):

2001314103

pISSN:

2147-9607