Renal Ultrastructural Alterations Following  Administration of Diethylstilbestrol

Bilge ONARLIOĞLU

Makale detayları

Renal Ultrastructural Alterations Following Administration of Diethylstilbestrol

Yazarlar:

Bilge ONARLIOĞLU

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 1998 Vol.28 Issue 4, pp.369-374

Belge Tipi:

Makale

Yayın Tarihi:

3/1998

Belge Dili:

Türkçe

Document ID (Org No.):

2000758307

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Anahtar kelimeler:

Özet:

 

Diethylstilbestrol (DES),  nonsteroid in structure, is an artificial  estrogen derivative and is used as an anabolic  agent. It is known that diethylstilbestrol  causes genetic disorders and toxic effects  leading up to carcinoma even in amounts  below its residual levels.  For this purpose, a dose of 60µm/kg/day of  DES dissolved in 0,1 ml corn oil has been  administered to rats by oral gavage for  varying periods of 20, 50 and 100 days  periods. Rat renal tissue samples, following  routine electron microscopical procedure,  have been examined by transmission electron  microscopy.  Following diethylstilbestrol administration,  glomerular capilleries seemed dilated along  with occasional basement membrane  thickenings and degenerations in slit  membrane. In addition, irregular endothelial  cell fenestrae were observed. Distal tubular  structure remained intact but in the proximal  tubuli, cells with picnotic nuclei and dilated  intracytoplasmic foldings were present.  These histological alterations increased  parallel to the duration of the dosage period.  These findings suggest that the  diethylstilbestrol usage may cause irreversible  structural changes in rat renal tissue.

 

Diethylstilbestrol (DES),  nonsteroid in structure, is an artificial  estrogen derivative and is used as an anabolic  agent. It is known that diethylstilbestrol  causes genetic disorders and toxic effects  leading up to carcinoma even in amounts  below its residual levels.  For this purpose, a dose of 60µm/kg/day of  DES dissolved in 0,1 ml corn oil has been  administered to rats by oral gavage for  varying periods of 20, 50 and 100 days  periods. Rat renal tissue samples, following  routine electron microscopical procedure,  have been examined by transmission electron  microscopy.  Following diethylstilbestrol administration,  glomerular capilleries seemed dilated along  with occasional basement membrane  thickenings and degenerations in slit  membrane. In addition, irregular endothelial  cell fenestrae were observed. Distal tubular  structure remained intact but in the proximal  tubuli, cells with picnotic nuclei and dilated  intracytoplasmic foldings were present.  These histological alterations increased  parallel to the duration of the dosage period.  These findings suggest that the  diethylstilbestrol usage may cause irreversible  structural changes in rat renal tissue.

Makale detayları

Renal Ultrastructural Alterations Following Administration of Diethylstilbestrol

Yazarlar:

Bilge ONARLIOĞLU

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 1998 Vol.28 Issue 4, pp.369-374

Belge Tipi:

Makale

Yayın Tarihi:

3/1998

Belge Dili:

Türkçe

Document ID (Org No.):

2000758307

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Diethylstilbestrol

kidney

ultrastructure

rat.

Sayı

Makale detayları

Renal Ultrastructural Alterations Following Administration of Diethylstilbestrol

Yazarlar: Bilge ONARLIOĞLU

Yayıncı: TUBITAK

Dergi: Turkish Journal of Medical Sciences 1998 Vol.28 Issue 4, pp.369-374

Belge Tipi: Makale

Yayın Tarihi: 3/1998

Belge Dili: Türkçe

Document ID (Org No.): 2000758307

Sıklık: İki Aylık

eISSN: 1303-6165

pISSN: 1300-0144

Diethylstilbestrol

kidney

ultrastructure

rat.

Sayı

Yazarlar:

Bilge ONARLIOĞLU

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 1998 Vol.28 Issue 4, pp.369-374

Belge Tipi:

Makale

Yayın Tarihi:

3/1998

Belge Dili:

Türkçe

Document ID (Org No.):

2000758307

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144