EVALUATION OF POTENTIAL DRUG INTERACTIONS IN THE ADULT BONE MARROW TRANSPLANTATION UNIT- A PROSPECTIVE STUDY

Gözde Seray Öztürk; Siret Ratip; Songul Tezcan

Makale detayları

EVALUATION OF POTENTIAL DRUG INTERACTIONS IN THE ADULT BONE MARROW TRANSPLANTATION UNIT- A PROSPECTIVE STUDY

Yazarlar:

Gözde Seray Öztürk | Siret Ratip | Songul Tezcan

Yayıncı:

Ankara University

Ana Başlıklar:

Eczacılık ve İlaç Bilimleri

Dergi:

Ankara Üniversitesi Eczacılık Fakültesi Dergisi Vol.47 Issue 2, pp.467-476

Belge Tipi:

Makale

Yayın Tarihi:

5/2023

Belge Dili:

Türkçe

Document ID (Org No.):

2001282818

pISSN:

1015-3918

Anahtar kelimeler:

Özet:

 Objective: Bone marrow treatment BMT is a long and complicated process with multiple drug use can lead to drug-drug interactions. The aim of our study is to evaluate potential drug interactions PDIs in patients hospitalized in the adult bone marrow transplantation unit. Material and Method: This was a prospective and descriptive study conducted in an adult BMT unit in a private hospital in Turkey between January-June 2021. Sociodemogphrapics of the patients were recorded. PDIs were analyzed via Medscape and Lexicomp drug interaction checker. SPSS 15 was used for analysis. Result and Discussion: Of 40 patients 22 55 were male and the mean age was 46. Most of the patients were diagnosed with multiple myeloma 35 and 58 of the patients had at least one comorbid disease. The number of PDIs detected in the Lexicomp database was statistically higher than in the Medscape database 299 vs 244; p0.05. More PDIS were found in patients with concomitant disease than in patients without p0.05. The number of comorbid diseases was found to be higher in this population. Additionally, the number of PDIs was found to be high. We think that clinical pharmacists have an important role in patient monitoring and management of PDIs in BMT units.

 Objective: Bone marrow treatment BMT is a long and complicated process with multiple drug use can lead to drug-drug interactions. The aim of our study is to evaluate potential drug interactions PDIs in patients hospitalized in the adult bone marrow transplantation unit. Material and Method: This was a prospective and descriptive study conducted in an adult BMT unit in a private hospital in Turkey between January-June 2021. Sociodemogphrapics of the patients were recorded. PDIs were analyzed via Medscape and Lexicomp drug interaction checker. SPSS 15 was used for analysis. Result and Discussion: Of 40 patients 22 55 were male and the mean age was 46. Most of the patients were diagnosed with multiple myeloma 35 and 58 of the patients had at least one comorbid disease. The number of PDIs detected in the Lexicomp database was statistically higher than in the Medscape database 299 vs 244; p0.05. More PDIS were found in patients with concomitant disease than in patients without p0.05. The number of comorbid diseases was found to be higher in this population. Additionally, the number of PDIs was found to be high. We think that clinical pharmacists have an important role in patient monitoring and management of PDIs in BMT units.

 Objective: Bone marrow treatment BMT is a long and complicated process with multiple drug use can lead to drug-drug interactions. The aim of our study is to evaluate potential drug interactions PDIs in patients hospitalized in the adult bone marrow transplantation unit. Material and Method: This was a prospective and descriptive study conducted in an adult BMT unit in a private hospital in Turkey between January-June 2021. Sociodemogphrapics of the patients were recorded. PDIs were analyzed via Medscape and Lexicomp drug interaction checker. SPSS 15 was used for analysis. Result and Discussion: Of 40 patients 22 55 were male and the mean age was 46. Most of the patients were diagnosed with multiple myeloma 35 and 58 of the patients had at least one comorbid disease. The number of PDIs detected in the Lexicomp database was statistically higher than in the Medscape database 299 vs 244; p0.05. More PDIS were found in patients with concomitant disease than in patients without p0.05. The number of comorbid diseases was found to be higher in this population. Additionally, the number of PDIs was found to be high. We think that clinical pharmacists have an important role in patient monitoring and management of PDIs in BMT units.

 Amaç: Kemik iliği nakli öncesi ve sonrasında yaşanan komplikasyonlar, uzun ve zorlu tedavi sürecinin ile çoklu ilaç kullanımı, ilaç-ilaç etkileşimlerine yol açabilmektedir. Çalışmamızın amacı, erişkin kemik iliği transplantasyon ünitesinde yatan hastalarda potansiyel ilaç etkileşimlerini değerlendirmektir. Gereç ve Yöntem: Bu çalışma, Türkiyede özel bir hastanenin erişkin kemik BMT ünitesinde Ocak-Haziran 2021 tarihleri arasında yapılmış prospektif ve tanımlayıcı bir çalışmadır. Hastaların sosyodemografik özellikleri kaydedilmiştir. Potansiyel ilaç etkileşimleri, Medscape ve Lexicomp ilaç etkileşimi veritabanları kullanılarak analiz edilmiştir. Analiz için SPSS 15 kullanılmıştır. Sonuç ve Tartışma: Çalışmaya dahil edilen 40 hastanın 22sinin 55 erkek hastalar olduğu ve medyan yaşın 48 olduğu tespit edilmiştir. Hastaların çoğuna multipl miyelom 35 tanısının konulduğu ve 58inde en az bir komorbid hastalık olduğu tespit edilmiştir. Yüksek doz melfalan rejimi en çok uygulanan rejim 25 olarak bulunmuştur. Lexicomp veri tabanında tespit edilen etkileşim sayısı, Medscape veri tabanından istatistiksel olarak daha fazla olduğu belirlenmiştir 299 vs 244; p0.05. Eşlik eden hastalığı olan hastalarda, olmayan hastalara göre daha fazla etkileşim saptanmıştır p0.05. Çalışmamızda kemik iliği nakli hastalarında komorbid hastalık sayısı daha fazla olduğu gözlenmiştir. Bu hastaların akılcı tedavi ve izlem gerektiren ilaç etkileşimleri sayısı yüksek olabilmektedir. Bu ünitelerde hasta takibi, ilaç etkileşimlerinin yönetiminde klinik eczacıların önemli bir rolü olduğunu düşünüyoruz.

Makale detayları

EVALUATION OF POTENTIAL DRUG INTERACTIONS IN THE ADULT BONE MARROW TRANSPLANTATION UNIT- A PROSPECTIVE STUDY

Yazarlar:

Gözde Seray Öztürk | Siret Ratip | Songul Tezcan

Yayıncı:

Ankara University

Ana Başlıklar:

Eczacılık ve İlaç Bilimleri

Dergi:

Ankara Üniversitesi Eczacılık Fakültesi Dergisi Vol.47 Issue 2, pp.467-476

Belge Tipi:

Makale

Yayın Tarihi:

5/2023

Belge Dili:

Türkçe

Document ID (Org No.):

2001282818

pISSN:

1015-3918

Bone marrow transplantation

clinical pharmacist

drug interactions

İlaç etkileşimi

kemik iliği transplantasyonu

klinik eczacı

Sayı

Makale detayları

EVALUATION OF POTENTIAL DRUG INTERACTIONS IN THE ADULT BONE MARROW TRANSPLANTATION UNIT- A PROSPECTIVE STUDY

Yazarlar: Gözde Seray Öztürk | Siret Ratip | Songul Tezcan

Yayıncı: Ankara University

Ana Başlıklar: Eczacılık ve İlaç Bilimleri

Dergi: Ankara Üniversitesi Eczacılık Fakültesi Dergisi Vol.47 Issue 2, pp.467-476

Belge Tipi: Makale

Yayın Tarihi: 5/2023

Belge Dili: Türkçe

Document ID (Org No.): 2001282818

pISSN: 1015-3918

Bone marrow transplantation

clinical pharmacist

drug interactions

İlaç etkileşimi

kemik iliği transplantasyonu

klinik eczacı

Sayı

Yazarlar:

Gözde Seray Öztürk | Siret Ratip | Songul Tezcan

Yayıncı:

Ankara University

Ana Başlıklar:

Eczacılık ve İlaç Bilimleri

Dergi:

Ankara Üniversitesi Eczacılık Fakültesi Dergisi Vol.47 Issue 2, pp.467-476

Belge Tipi:

Makale

Yayın Tarihi:

5/2023

Belge Dili:

Türkçe

Document ID (Org No.):

2001282818

pISSN:

1015-3918