The optimal dose of vitamin D in growing girls during academic years: a randomized trial

Mehrdad SHAKINBA; Samane TEFAGH; Zahra NAFEI

Makale detayları

The optimal dose of vitamin D in growing girls during academic years: a randomized trial

Yazarlar:

Mehrdad SHAKINBA | Samane TEFAGH | Zahra NAFEI

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2011 Vol.41 Issue 1, pp.33-37

Belge Tipi:

Makale

Yayın Tarihi:

12/2010

Belge Dili:

Türkçe

Document ID (Org No.):

2000754820

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Anahtar kelimeler:

Özet:

 

Prevalence of vitamin D deficiency is remarkable during childhood and adolescence throughout the world. Sufficient intake of vitamin D contributes to a number of health outcomes. The aim of this study was to specify the optimal dose of vitamin D in growing girls in a Muslim country during an academic year.  Materials and methods: This randomized clinical trial study was carried out in Yazd in the center of Iran in 2007;120 junior high school girls (aged 12-15 years) were randomly divided into 4 groups. Sixty students in groups I and II were treated for vitamin D deficiency with 300,000 IU vitamin D3 and then randomly received 50,000 U/monthly or 100,000IU/3 months vitamin D3; 60 other students in groups III and IV received 50,000 IU/3 months and 100,000/3 months from the beginning of the academic year. Medication continued for the entire academic year; 1 month after the last dose, serum 25(OH)D levels were measured.   Results: The mean level of 25 (OH) D was 29.7 ± 4.60 ng/mL in group I and 30 ± 5.61 ng/mL in group II. Mean serum levels of 25 (OH) D were 15.2 ± 6 ng/mL and 23 ± 6.8 ng/mL for groups III and IV, respectively.  Conclusion: Neither doses of about 800 IU/day nor 1000 IU/day are sufficient to maintain 25(OH)D in optimal level (> 20 ng/mL) for all, but after  the treatment of deficiency, intakes of about 1000 IU/day or 2000 IU/day of vitamin D maintained optimal level in all of the students.

 

Prevalence of vitamin D deficiency is remarkable during childhood and adolescence throughout the world. Sufficient intake of vitamin D contributes to a number of health outcomes. The aim of this study was to specify the optimal dose of vitamin D in growing girls in a Muslim country during an academic year.  Materials and methods: This randomized clinical trial study was carried out in Yazd in the center of Iran in 2007;120 junior high school girls (aged 12-15 years) were randomly divided into 4 groups. Sixty students in groups I and II were treated for vitamin D deficiency with 300,000 IU vitamin D3 and then randomly received 50,000 U/monthly or 100,000IU/3 months vitamin D3; 60 other students in groups III and IV received 50,000 IU/3 months and 100,000/3 months from the beginning of the academic year. Medication continued for the entire academic year; 1 month after the last dose, serum 25(OH)D levels were measured.   Results: The mean level of 25 (OH) D was 29.7 ± 4.60 ng/mL in group I and 30 ± 5.61 ng/mL in group II. Mean serum levels of 25 (OH) D were 15.2 ± 6 ng/mL and 23 ± 6.8 ng/mL for groups III and IV, respectively.  Conclusion: Neither doses of about 800 IU/day nor 1000 IU/day are sufficient to maintain 25(OH)D in optimal level (> 20 ng/mL) for all, but after  the treatment of deficiency, intakes of about 1000 IU/day or 2000 IU/day of vitamin D maintained optimal level in all of the students.

Makale detayları

The optimal dose of vitamin D in growing girls during academic years: a randomized trial

Yazarlar:

Mehrdad SHAKINBA | Samane TEFAGH | Zahra NAFEI

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2011 Vol.41 Issue 1, pp.33-37

Belge Tipi:

Makale

Yayın Tarihi:

12/2010

Belge Dili:

Türkçe

Document ID (Org No.):

2000754820

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Key words: Vitamin D

girl

bolus therapy

25OH vitamin D

Sayı

Makale detayları

The optimal dose of vitamin D in growing girls during academic years: a randomized trial

Yazarlar: Mehrdad SHAKINBA | Samane TEFAGH | Zahra NAFEI

Yayıncı: TUBITAK

Dergi: Turkish Journal of Medical Sciences 2011 Vol.41 Issue 1, pp.33-37

Belge Tipi: Makale

Yayın Tarihi: 12/2010

Belge Dili: Türkçe

Document ID (Org No.): 2000754820

Sıklık: İki Aylık

eISSN: 1303-6165

pISSN: 1300-0144

Key words: Vitamin D

girl

bolus therapy

25OH vitamin D

Sayı

Yazarlar:

Mehrdad SHAKINBA | Samane TEFAGH | Zahra NAFEI

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2011 Vol.41 Issue 1, pp.33-37

Belge Tipi:

Makale

Yayın Tarihi:

12/2010

Belge Dili:

Türkçe

Document ID (Org No.):

2000754820

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144