Posaconazole Loading and Release Behavior in Surface-Modified Mesoporous Silica Nanoparticular System

Hilal Erkan; Ceren Keçeciler-emir; Cem Özel; Sevil Yücel

Makale detayları

Posaconazole Loading and Release Behavior in Surface-Modified Mesoporous Silica Nanoparticular System

Yazarlar:

Hilal Erkan | Ceren Keçeciler-emir | Cem Özel | Sevil Yücel

Yayıncı:

Erzincan Binali Yildirim University

Ana Başlıklar:

Mühendislik

Dergi:

Erzincan Üniversitesi Fen Bilimleri Enstitüsü Dergisi Vol.16 Issue 3, pp.615-632

Belge Tipi:

Makale

Yayın Tarihi:

12/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001306725

pISSN:

2149-4584

Anahtar kelimeler:

Özet:

 In conventional drug treatments, high toxic effects, low solubility, and low bioavailability of the active substance cause insufficient drug release in the target tissue and undesirable side effects in healthy tissue. Various drug delivery systems are utilized to eliminate these undesirable effects. Mesoporous silica nanoparticles MSN are biocompatible biomaterials that have a large surface area, high pore volume, and enhanced adsorption capacity. With MSN-mediated controlled drug release, the active substance concentration in the blood is kept within the desired therapeutic range. Posaconazole PCZ is an antifungal agent. Absorption of PCZ is difficult due to its low solubility in aqueous and acidic environments, low therapeutic effect and low bioavailability. The use of controlled drug release systems avoids these problems and facilitates the absorption and release of PCZ. In this study, it is aimed to enhance the PCZ adsorption and release by using a drug delivery system. MSNs were synthesized by sol-gel method, and surface modification of nanoparticles was achieved using 3-Aminopropyl triethoxysilane APTES. PCZ was loaded on APTES-modified MSN successfully. MSN, APTES-modified MSN and PCZ loaded APTES-modified MSN were characterized. Diffusion controlled release of PCZ was observed in drug release studies.

 In conventional drug treatments, high toxic effects, low solubility, and low bioavailability of the active substance cause insufficient drug release in the target tissue and undesirable side effects in healthy tissue. Various drug delivery systems are utilized to eliminate these undesirable effects. Mesoporous silica nanoparticles MSN are biocompatible biomaterials that have a large surface area, high pore volume, and enhanced adsorption capacity. With MSN-mediated controlled drug release, the active substance concentration in the blood is kept within the desired therapeutic range. Posaconazole PCZ is an antifungal agent. Absorption of PCZ is difficult due to its low solubility in aqueous and acidic environments, low therapeutic effect and low bioavailability. The use of controlled drug release systems avoids these problems and facilitates the absorption and release of PCZ. In this study, it is aimed to enhance the PCZ adsorption and release by using a drug delivery system. MSNs were synthesized by sol-gel method, and surface modification of nanoparticles was achieved using 3-Aminopropyl triethoxysilane APTES. PCZ was loaded on APTES-modified MSN successfully. MSN, APTES-modified MSN and PCZ loaded APTES-modified MSN were characterized. Diffusion controlled release of PCZ was observed in drug release studies.

 In conventional drug treatments, high toxic effects, low solubility, and low bioavailability of the active substance cause insufficient drug release in the target tissue and undesirable side effects in healthy tissue. Various drug delivery systems are utilized to eliminate these undesirable effects. Mesoporous silica nanoparticles MSN are biocompatible biomaterials that have a large surface area, high pore volume, and enhanced adsorption capacity. With MSN-mediated controlled drug release, the active substance concentration in the blood is kept within the desired therapeutic range. Posaconazole PCZ is an antifungal agent. Absorption of PCZ is difficult due to its low solubility in aqueous and acidic environments, low therapeutic effect and low bioavailability. The use of controlled drug release systems avoids these problems and facilitates the absorption and release of PCZ. In this study, it is aimed to enhance the PCZ adsorption and release by using a drug delivery system. MSNs were synthesized by sol-gel method, and surface modification of nanoparticles was achieved using 3-Aminopropyl triethoxysilane APTES. PCZ was loaded on APTES-modified MSN successfully. MSN, APTES-modified MSN and PCZ loaded APTES-modified MSN were characterized. Diffusion controlled release of PCZ was observed in drug release studies.

 In conventional drug treatments, high toxic effects, low solubility, and low bioavailability of the active substance cause insufficient drug release in the target tissue and undesirable side effects in healthy tissue. Various drug delivery systems are utilized to eliminate these undesirable effects. Mesoporous silica nanoparticles MSN are biocompatible biomaterials that have a large surface area, high pore volume, and enhanced adsorption capacity. With MSN-mediated controlled drug release, the active substance concentration in the blood is kept within the desired therapeutic range. Posaconazole PCZ is an antifungal agent. Absorption of PCZ is difficult due to its low solubility in aqueous and acidic environments, low therapeutic effect and low bioavailability. The use of controlled drug release systems avoids these problems and facilitates the absorption and release of PCZ. In this study, it is aimed to enhance the PCZ adsorption and release by using a drug delivery system. MSNs were synthesized by sol-gel method, and surface modification of nanoparticles was achieved using 3-Aminopropyl triethoxysilane APTES. PCZ was loaded on APTES-modified MSN successfully. MSN, APTES-modified MSN and PCZ loaded APTES-modified MSN were characterized. Diffusion controlled release of PCZ was observed in drug release studies.

Makale detayları

Posaconazole Loading and Release Behavior in Surface-Modified Mesoporous Silica Nanoparticular System

Yazarlar:

Hilal Erkan | Ceren Keçeciler-emir | Cem Özel | Sevil Yücel

Yayıncı:

Erzincan Binali Yildirim University

Ana Başlıklar:

Mühendislik

Dergi:

Erzincan Üniversitesi Fen Bilimleri Enstitüsü Dergisi Vol.16 Issue 3, pp.615-632

Belge Tipi:

Makale

Yayın Tarihi:

12/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001306725

pISSN:

2149-4584

Antifungal

Drug delivery system

Nanoparticle

Posaconazole

Silica

Sayı

Makale detayları

Posaconazole Loading and Release Behavior in Surface-Modified Mesoporous Silica Nanoparticular System

Yazarlar: Hilal Erkan | Ceren Keçeciler-emir | Cem Özel | Sevil Yücel

Yayıncı: Erzincan Binali Yildirim University

Ana Başlıklar: Mühendislik

Dergi: Erzincan Üniversitesi Fen Bilimleri Enstitüsü Dergisi Vol.16 Issue 3, pp.615-632

Belge Tipi: Makale

Yayın Tarihi: 12/2023

Belge Dili: İngilizce

Document ID (Org No.): 2001306725

pISSN: 2149-4584

Antifungal

Drug delivery system

Nanoparticle

Posaconazole

Silica

Sayı

Yazarlar:

Hilal Erkan | Ceren Keçeciler-emir | Cem Özel | Sevil Yücel

Yayıncı:

Erzincan Binali Yildirim University

Ana Başlıklar:

Mühendislik

Dergi:

Erzincan Üniversitesi Fen Bilimleri Enstitüsü Dergisi Vol.16 Issue 3, pp.615-632

Belge Tipi:

Makale

Yayın Tarihi:

12/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001306725

pISSN:

2149-4584