In Vitro Activity of Tigecycline Against Acinetobacter baumannii Strains Isolated From Nosocomial Infections

Esragül AKINCI; İpek MUMCUOĞLU; Pınar ÖNGÜRÜ

Makale detayları

In Vitro Activity of Tigecycline Against Acinetobacter baumannii Strains Isolated From Nosocomial Infections

Yazarlar:

Esragül AKINCI | İpek MUMCUOĞLU | Pınar ÖNGÜRÜ

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2008 Vol.38 Issue 6, pp.583-586

Belge Tipi:

Makale

Yayın Tarihi:

5/2008

Belge Dili:

Türkçe

Document ID (Org No.):

2000755674

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Anahtar kelimeler:

Özet:

 

Aims: Acinetobacter species usually affect hospitalized patients and are involved in many infections associated with a high mortality rate. Management of infections caused by these strains is very difficult, as the strains often display multiple drug resistance, including carbapenem resistance. Tigecycline is the most recently developed semi-synthetic broad spectrum glycylcycline antibiotic. The present study was conducted to evaluate the in vitro susceptibility of Acinetobacter baumannii strains isolated from the hospitalized patients to tigecycline.  Materials and Methods: Acinetobacter isolates were collected from hospitalized patients with documented nosocomial infections between June 2005 and October 2006. Only one isolate per patient was accepted. Minimum inhibitory concentrations (MICs) were determined by E-test against tigecycline and other frequently used antibiotics.  Results: Overall, 98 A. baumannii isolates were collected from the cultures of nosocomially infected patients. Tigecycline was the most active agent against A. baumannii isolates among those tested, followed by netilmicin. MIC values of tigecycline were.

 

Aims: Acinetobacter species usually affect hospitalized patients and are involved in many infections associated with a high mortality rate. Management of infections caused by these strains is very difficult, as the strains often display multiple drug resistance, including carbapenem resistance. Tigecycline is the most recently developed semi-synthetic broad spectrum glycylcycline antibiotic. The present study was conducted to evaluate the in vitro susceptibility of Acinetobacter baumannii strains isolated from the hospitalized patients to tigecycline.  Materials and Methods: Acinetobacter isolates were collected from hospitalized patients with documented nosocomial infections between June 2005 and October 2006. Only one isolate per patient was accepted. Minimum inhibitory concentrations (MICs) were determined by E-test against tigecycline and other frequently used antibiotics.  Results: Overall, 98 A. baumannii isolates were collected from the cultures of nosocomially infected patients. Tigecycline was the most active agent against A. baumannii isolates among those tested, followed by netilmicin. MIC values of tigecycline were.

Makale detayları

In Vitro Activity of Tigecycline Against Acinetobacter baumannii Strains Isolated From Nosocomial Infections

Yazarlar: Esragül AKINCI | İpek MUMCUOĞLU | Pınar ÖNGÜRÜ

Yayıncı: TUBITAK

Dergi: Turkish Journal of Medical Sciences 2008 Vol.38 Issue 6, pp.583-586

Belge Tipi: Makale

Yayın Tarihi: 5/2008

Belge Dili: Türkçe

Document ID (Org No.): 2000755674

Sıklık: İki Aylık

eISSN: 1303-6165

pISSN: 1300-0144

Tigecycline

Acinetobacter

antibiotic

resistance

Sayı

Yazarlar:

Esragül AKINCI | İpek MUMCUOĞLU | Pınar ÖNGÜRÜ

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2008 Vol.38 Issue 6, pp.583-586

Belge Tipi:

Makale

Yayın Tarihi:

5/2008

Belge Dili:

Türkçe

Document ID (Org No.):

2000755674

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144