Determination of lidocaine based on electrocatalysis of a chemically modified electrode

Gamze TAN; Gülçin BOLAT; Mehmet Ali ONUR; Serdar ABACI

Makale detayları

Determination of lidocaine based on electrocatalysis of a chemically modified electrode

Yazarlar:

Gamze TAN | Gülçin BOLAT | Mehmet Ali ONUR | Serdar ABACI

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Chemistry 2012 Vol.36 Issue 4, pp.593-600

Belge Tipi:

Makale

Yayın Tarihi:

3/2012

Belge Dili:

Türkçe

Document ID (Org No.):

2000727594

Sıklık:

İki Aylık

eISSN:

1303-6130

pISSN:

1300-0527

Özet:

 

The potential application of biochemically modified  electrodes was investigated for construction of a drug biosensor.  The  electrocatalytic response of lidocaine was examined through modified  electrodes using the electron transfer ability of hemoglobin (Hb)  immobilized on gold film modified with a self-assembled monolayer  (SAM) of 3-mercaptopropionic acid (MPA).  According to the results of  voltammetric studies, Au/MPA/Hb electrodes exhibited high sensitivity  and good electrocatalytic activity for the reduction of lidocaine,  motivating us to construct drug biosensors.  With this study, a new  electroanalytical procedure is proposed for the determination of  lidocaine level in medical applications or therapeutic formulations  containing lidocaine as the active ingredient.

 

The potential application of biochemically modified  electrodes was investigated for construction of a drug biosensor.  The  electrocatalytic response of lidocaine was examined through modified  electrodes using the electron transfer ability of hemoglobin (Hb)  immobilized on gold film modified with a self-assembled monolayer  (SAM) of 3-mercaptopropionic acid (MPA).  According to the results of  voltammetric studies, Au/MPA/Hb electrodes exhibited high sensitivity  and good electrocatalytic activity for the reduction of lidocaine,  motivating us to construct drug biosensors.  With this study, a new  electroanalytical procedure is proposed for the determination of  lidocaine level in medical applications or therapeutic formulations  containing lidocaine as the active ingredient.

Makale detayları

Determination of lidocaine based on electrocatalysis of a chemically modified electrode

Yazarlar: Gamze TAN | Gülçin BOLAT | Mehmet Ali ONUR | Serdar ABACI

Yayıncı: TUBITAK

Dergi: Turkish Journal of Chemistry 2012 Vol.36 Issue 4, pp.593-600

Belge Tipi: Makale

Yayın Tarihi: 3/2012

Belge Dili: Türkçe

Document ID (Org No.): 2000727594

Sıklık: İki Aylık

eISSN: 1303-6130

pISSN: 1300-0527

Sayı

Yazarlar:

Gamze TAN | Gülçin BOLAT | Mehmet Ali ONUR | Serdar ABACI

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Chemistry 2012 Vol.36 Issue 4, pp.593-600

Belge Tipi:

Makale

Yayın Tarihi:

3/2012

Belge Dili:

Türkçe

Document ID (Org No.):

2000727594

Sıklık:

İki Aylık

eISSN:

1303-6130

pISSN:

1300-0527