The Atomic Absorption Spectrophotometric Method for Indirect Determination of Nimodipine in Tablets

Mevlüde CANLICA; Sezen İSLİMYELİ

Makale detayları

The Atomic Absorption Spectrophotometric Method for Indirect Determination of Nimodipine in Tablets

Yazarlar:

Mevlüde CANLICA | Sezen İSLİMYELİ

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Chemistry 2005 Vol.29 Issue 2, pp.141-146

Belge Tipi:

Makale

Yayın Tarihi:

1/2005

Belge Dili:

Türkçe

Document ID (Org No.):

2000729125

Sıklık:

İki Aylık

eISSN:

1303-6130

pISSN:

1300-0527

Özet:

 

A simple indirect atomic absorption spectrophotometric (AAS)  method is described for the analysis of nimodipine in tablet  formulations.  The method is based on the reduction of the  antihypertensive drug substances including an aromatic nitro group by  boiling them with cadmium metal in 0.05 N HC??l medium under CO2  atmosphere for 1 h under reflux.  The amounts of the drugs were  calculated by determining the atomic absorbances of the released  Cd+2.  The calibration graphs were plotted between the absorbance  Cd+2 concentrations in the range of 0.242 to 1.209 m g.cm-3  for nimodipine.  As a reference method, the spectrophotometric  procedure was developed.  The 2 methods developed were applied to the  assay of nimodipine in commercial tablet formulations, and a  statistical comparison of the results with those obtained from the  reference method showed good agreement.  The method has the advantage  of being simple, inexpensive, and easy to perform.

 

A simple indirect atomic absorption spectrophotometric (AAS)  method is described for the analysis of nimodipine in tablet  formulations.  The method is based on the reduction of the  antihypertensive drug substances including an aromatic nitro group by  boiling them with cadmium metal in 0.05 N HC??l medium under CO2  atmosphere for 1 h under reflux.  The amounts of the drugs were  calculated by determining the atomic absorbances of the released  Cd+2.  The calibration graphs were plotted between the absorbance  Cd+2 concentrations in the range of 0.242 to 1.209 m g.cm-3  for nimodipine.  As a reference method, the spectrophotometric  procedure was developed.  The 2 methods developed were applied to the  assay of nimodipine in commercial tablet formulations, and a  statistical comparison of the results with those obtained from the  reference method showed good agreement.  The method has the advantage  of being simple, inexpensive, and easy to perform.

Makale detayları

The Atomic Absorption Spectrophotometric Method for Indirect Determination of Nimodipine in Tablets

Yazarlar: Mevlüde CANLICA | Sezen İSLİMYELİ

Yayıncı: TUBITAK

Dergi: Turkish Journal of Chemistry 2005 Vol.29 Issue 2, pp.141-146

Belge Tipi: Makale

Yayın Tarihi: 1/2005

Belge Dili: Türkçe

Document ID (Org No.): 2000729125

Sıklık: İki Aylık

eISSN: 1303-6130

pISSN: 1300-0527

Sayı

Yazarlar:

Mevlüde CANLICA | Sezen İSLİMYELİ

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Chemistry 2005 Vol.29 Issue 2, pp.141-146

Belge Tipi:

Makale

Yayın Tarihi:

1/2005

Belge Dili:

Türkçe

Document ID (Org No.):

2000729125

Sıklık:

İki Aylık

eISSN:

1303-6130

pISSN:

1300-0527