Prevalence of non-alcoholic fatty liver disease is not increased in patients with celiac disease:  a cross-sectional study

Ayşe Kefeli; Feyyaz Onayrılı; Ayşe Kevser Demir

Makale detayları

Prevalence of non-alcoholic fatty liver disease is not increased in patients with celiac disease: a cross-sectional study

Yazarlar:

Ayşe Kefeli | Feyyaz Onayrılı | Ayşe Kevser Demir

Yayıncı:

Tokat Gaziosmanpasa University

Ana Başlıklar:

İç Hastalıkları

Dergi:

International Journal of Tokat Medical Sciences Vol.16 Issue 2, pp.45-56

Belge Tipi:

Makale

Yayın Tarihi:

8/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001325644

pISSN:

3061-9912

Anahtar kelimeler:

Özet:

 Objective: Celiac disease CD is associated with liver diseases and could be associated Non-alcoholic fatty liver disease NAFLD due both diseases have same etiopathogenetic risk factors such as altered gut microbiota and intestinal permeability. Despite this tight association of these disease, there are few studies on this subject. Therefore, we aimed to determine the prevalence of NAFLD in patients with celiac disease. Material and Methods: This cross sectional, was carried out in a tertiary health center. The aim of the study is to determine the frequency of NAFLD in CD patients treated with a gluten-free diet GFD for at least 6 months. The secondary aim was to assess the relative risk of NAFLD in CD patients treated with a GFD for at least 6 months. Patients with diagnosed CD and a GFD was initiated at least 6 months before were included the study as a group A. The control group group B was selected from the outpatients who applied to our polyclinic with dyspepsia. Hepatosteatosis was diagnosed by ultrasonographic examination. Results: Group A and Group B were similar in terms of age, gender frequency, body mass index BMI and presence of diabetes mellitus. The frequency of NAFLD was 22.7 in Group A and 28.1 in Group B P  0.35. Advanced age, high BMI, high blood sugar, presence of DM was a risk factor for NAFLD. Conclusion: Individuals with celiac disease are not at increased risk of nonalcoholic fatty liver disease compared to the general population.

 Objective: Celiac disease CD is associated with liver diseases and could be associated Non-alcoholic fatty liver disease NAFLD due both diseases have same etiopathogenetic risk factors such as altered gut microbiota and intestinal permeability. Despite this tight association of these disease, there are few studies on this subject. Therefore, we aimed to determine the prevalence of NAFLD in patients with celiac disease. Material and Methods: This cross sectional, was carried out in a tertiary health center. The aim of the study is to determine the frequency of NAFLD in CD patients treated with a gluten-free diet GFD for at least 6 months. The secondary aim was to assess the relative risk of NAFLD in CD patients treated with a GFD for at least 6 months. Patients with diagnosed CD and a GFD was initiated at least 6 months before were included the study as a group A. The control group group B was selected from the outpatients who applied to our polyclinic with dyspepsia. Hepatosteatosis was diagnosed by ultrasonographic examination. Results: Group A and Group B were similar in terms of age, gender frequency, body mass index BMI and presence of diabetes mellitus. The frequency of NAFLD was 22.7 in Group A and 28.1 in Group B P  0.35. Advanced age, high BMI, high blood sugar, presence of DM was a risk factor for NAFLD. Conclusion: Individuals with celiac disease are not at increased risk of nonalcoholic fatty liver disease compared to the general population.

 Objective: Celiac disease CD is associated with liver diseases and could be associated Non-alcoholic fatty liver disease NAFLD due both diseases have same etiopathogenetic risk factors such as altered gut microbiota and intestinal permeability. Despite this tight association of these disease, there are few studies on this subject. Therefore, we aimed to determine the prevalence of NAFLD in patients with celiac disease. Material and Methods: This cross sectional, was carried out in a tertiary health center. The aim of the study is to determine the frequency of NAFLD in CD patients treated with a gluten-free diet GFD for at least 6 months. The secondary aim was to assess the relative risk of NAFLD in CD patients treated with a GFD for at least 6 months. Patients with diagnosed CD and a GFD was initiated at least 6 months before were included the study as a group A. The control group group B was selected from the outpatients who applied to our polyclinic with dyspepsia. Hepatosteatosis was diagnosed by ultrasonographic examination. Results: Group A and Group B were similar in terms of age, gender frequency, body mass index BMI and presence of diabetes mellitus. The frequency of NAFLD was 22.7 in Group A and 28.1 in Group B P  0.35. Advanced age, high BMI, high blood sugar, presence of DM was a risk factor for NAFLD. Conclusion: Individuals with celiac disease are not at increased risk of nonalcoholic fatty liver disease compared to the general population.

 Amaç: Çölyak Hastalığı CH, karaciğer hastalıklarıyla ilişkilidir. Her iki hastalıkta; bağırsak mikrobiyotasında değişiklik ve bağırsak geçirgenliği gibi aynı etiyopatogenetik risk faktörlerine sahip olması nedeniyle alkolik olmayan yağlı karaciğer hastalığı AOYKH ile ilişkilendirilebilir. Bu hastalıkların bu yakın lişkisine rağmen, bu konuda çok az çalışma yapılmıştır. Bu nedenle, biz çalışmamızda ÇH olan hastalarda AOYKH yaygınlığını belirlemeyi amaçladık. Gereç ve Yöntem: Kesitsel nitelikte çalışmamız; üçüncü basamak bir sağlık merkezinde gerçekleştirildi. Çalışmanın ilk amacı, en az 6 ay boyunca glutensiz diyet ile tedavi edilen ÇH AOYKH sıklığını belirlemektir. İkincil olarak da; en az 6 ay boyunca glütensiz diyet ile tedavi edilen ÇH AOYKHnın göreceli riskini değerlendirmektir. Tanısı konulmuş ÇH ve en az 6 ay önce glutensiz diyet başlatılmış hastalar çalışmaya Grup A olarak alındı. Kontrol grubu Grup B, polikliniğimize dispepsi ile başvuran ayaktan hastalar arasından seçildi. Hepatosteatoz, ultrasonografik inceleme ile teşhis edildi. Bulgular: Grup A ve Grup B, yaş, cinsiyet, vücut kitle indeksi VKİ ve diabetes mellitus DM varlığı açısından benzerdi. Alkolik olmayan yağlı karaciğer hastalığı sıklığı Grup Ada 22,7 iken, Grup Bde 28,1 idi P  0,35. İleri yaş, yüksek VKİ, yüksek kan şekeri, DM varlığı AOYKH için bir risk faktörüydü. Sonuç: Çölyak hastalığı olan bireyler, genel popülasyona kıyasla alkolik olmayan yağlı karaciğer hastalığı açısından artmış risk altında değildir.

Makale detayları

Prevalence of non-alcoholic fatty liver disease is not increased in patients with celiac disease: a cross-sectional study

Yazarlar:

Ayşe Kefeli | Feyyaz Onayrılı | Ayşe Kevser Demir

Yayıncı:

Tokat Gaziosmanpasa University

Ana Başlıklar:

İç Hastalıkları

Dergi:

International Journal of Tokat Medical Sciences Vol.16 Issue 2, pp.45-56

Belge Tipi:

Makale

Yayın Tarihi:

8/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001325644

pISSN:

3061-9912

Ultrasonography

non-alcoholic fatty liver disease

celiac diseaseUltrasonografi

alkolik olmayan yağlı karaciğer hastalığı

çölyak hastalığı

Sayı

Makale detayları

Prevalence of non-alcoholic fatty liver disease is not increased in patients with celiac disease: a cross-sectional study

Yazarlar: Ayşe Kefeli | Feyyaz Onayrılı | Ayşe Kevser Demir

Yayıncı: Tokat Gaziosmanpasa University

Ana Başlıklar: İç Hastalıkları

Dergi: International Journal of Tokat Medical Sciences Vol.16 Issue 2, pp.45-56

Belge Tipi: Makale

Yayın Tarihi: 8/2024

Belge Dili: İngilizce

Document ID (Org No.): 2001325644

pISSN: 3061-9912

Ultrasonography

non-alcoholic fatty liver disease

celiac diseaseUltrasonografi

alkolik olmayan yağlı karaciğer hastalığı

çölyak hastalığı

Sayı

Yazarlar:

Ayşe Kefeli | Feyyaz Onayrılı | Ayşe Kevser Demir

Yayıncı:

Tokat Gaziosmanpasa University

Ana Başlıklar:

İç Hastalıkları

Dergi:

International Journal of Tokat Medical Sciences Vol.16 Issue 2, pp.45-56

Belge Tipi:

Makale

Yayın Tarihi:

8/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001325644

pISSN:

3061-9912