Relationship Between Serum Inflammatory Markers and Olfactory Function in Polypoid and Non-Polypoid Chronic Rhinosinusitis

Ali Amca; Elvan Evrim Tuna; Melih Çayönü; Zehra Betül Paksoy

Makale detayları

Relationship Between Serum Inflammatory Markers and Olfactory Function in Polypoid and Non-Polypoid Chronic Rhinosinusitis

Yazarlar:

Ali Amca | Elvan Evrim Tuna | Melih Çayönü | Zehra Betül Paksoy

Yayıncı:

Istanbul University

Ana Başlıklar:

Otorhinolaryngology | Clinical Sciences (Other)

Dergi:

The Turkish Journal of Ear Nose and Throat Vol.35 Issue 3, pp.149-154

Belge Tipi:

Makale

Yayın Tarihi:

9/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001360097

pISSN:

2602-4837

Anahtar kelimeler:

Özet:

 Objective: This study aimed to investigate the association between serum inflammatory markers, partic0 ularly the Systemic Immune0Inflammatory Index SII, and disease severity and olfactory function in patients with chronic rhinosinusitis CRS. Materials and Methods: A total of 59 CRS patients and 29 healthy controls were included. Patients were categorised as CRSsNP n30 or CRSwNP n29. Olfactory function was assessed with the Sniffin Sticks test, whereas disease severity was evaluated using the LundKennedy endoscopic and LundMackay radiological staging systems. Quality of life was measured using the SNOT022 questionnaire. Inflammatory indices, including NLR, PLR, ELR, and SII, as well as eosinophil counts and total serum IgE levels, were analysed. Results: Compared with controls, CRSwNP patients demonstrated significantly higher eosinophil counts and ELR values p0.001. No significant differences were observed for IgE, NLR, PLR, or SII levels between the groups p0.248. Olfactory scores showed a significant negative correlation with both radiological and endoscopic staging. Importantly, systemic inflammatory indices such as SII and NLR were not associated with olfactory dysfunction, suggesting their limited diagnostic utility in CRS. Conclusion: While most systemic inflammatory indices did not correlate with olfactory performance or disease severity, ELR and eosinophil counts were markedly elevated in patients with CRSwNP, highlighting the potential disease0specific relevance of ELR in CRS0related olfactory dysfunction.

 Objective: This study aimed to investigate the association between serum inflammatory markers, partic0 ularly the Systemic Immune0Inflammatory Index SII, and disease severity and olfactory function in patients with chronic rhinosinusitis CRS. Materials and Methods: A total of 59 CRS patients and 29 healthy controls were included. Patients were categorised as CRSsNP n30 or CRSwNP n29. Olfactory function was assessed with the Sniffin Sticks test, whereas disease severity was evaluated using the LundKennedy endoscopic and LundMackay radiological staging systems. Quality of life was measured using the SNOT022 questionnaire. Inflammatory indices, including NLR, PLR, ELR, and SII, as well as eosinophil counts and total serum IgE levels, were analysed. Results: Compared with controls, CRSwNP patients demonstrated significantly higher eosinophil counts and ELR values p0.001. No significant differences were observed for IgE, NLR, PLR, or SII levels between the groups p0.248. Olfactory scores showed a significant negative correlation with both radiological and endoscopic staging. Importantly, systemic inflammatory indices such as SII and NLR were not associated with olfactory dysfunction, suggesting their limited diagnostic utility in CRS. Conclusion: While most systemic inflammatory indices did not correlate with olfactory performance or disease severity, ELR and eosinophil counts were markedly elevated in patients with CRSwNP, highlighting the potential disease0specific relevance of ELR in CRS0related olfactory dysfunction.

 Objective: This study aimed to investigate the association between serum inflammatory markers, partic0 ularly the Systemic Immune0Inflammatory Index SII, and disease severity and olfactory function in patients with chronic rhinosinusitis CRS. Materials and Methods: A total of 59 CRS patients and 29 healthy controls were included. Patients were categorised as CRSsNP n30 or CRSwNP n29. Olfactory function was assessed with the Sniffin Sticks test, whereas disease severity was evaluated using the LundKennedy endoscopic and LundMackay radiological staging systems. Quality of life was measured using the SNOT022 questionnaire. Inflammatory indices, including NLR, PLR, ELR, and SII, as well as eosinophil counts and total serum IgE levels, were analysed. Results: Compared with controls, CRSwNP patients demonstrated significantly higher eosinophil counts and ELR values p0.001. No significant differences were observed for IgE, NLR, PLR, or SII levels between the groups p0.248. Olfactory scores showed a significant negative correlation with both radiological and endoscopic staging. Importantly, systemic inflammatory indices such as SII and NLR were not associated with olfactory dysfunction, suggesting their limited diagnostic utility in CRS. Conclusion: While most systemic inflammatory indices did not correlate with olfactory performance or disease severity, ELR and eosinophil counts were markedly elevated in patients with CRSwNP, highlighting the potential disease0specific relevance of ELR in CRS0related olfactory dysfunction.

 Objective: This study aimed to investigate the association between serum inflammatory markers, partic0 ularly the Systemic Immune0Inflammatory Index SII, and disease severity and olfactory function in patients with chronic rhinosinusitis CRS. Materials and Methods: A total of 59 CRS patients and 29 healthy controls were included. Patients were categorised as CRSsNP n30 or CRSwNP n29. Olfactory function was assessed with the Sniffin Sticks test, whereas disease severity was evaluated using the LundKennedy endoscopic and LundMackay radiological staging systems. Quality of life was measured using the SNOT022 questionnaire. Inflammatory indices, including NLR, PLR, ELR, and SII, as well as eosinophil counts and total serum IgE levels, were analysed. Results: Compared with controls, CRSwNP patients demonstrated significantly higher eosinophil counts and ELR values p0.001. No significant differences were observed for IgE, NLR, PLR, or SII levels between the groups p0.248. Olfactory scores showed a significant negative correlation with both radiological and endoscopic staging. Importantly, systemic inflammatory indices such as SII and NLR were not associated with olfactory dysfunction, suggesting their limited diagnostic utility in CRS. Conclusion: While most systemic inflammatory indices did not correlate with olfactory performance or disease severity, ELR and eosinophil counts were markedly elevated in patients with CRSwNP, highlighting the potential disease0specific relevance of ELR in CRS0related olfactory dysfunction.

Makale detayları

Relationship Between Serum Inflammatory Markers and Olfactory Function in Polypoid and Non-Polypoid Chronic Rhinosinusitis

Yazarlar:

Ali Amca | Elvan Evrim Tuna | Melih Çayönü | Zehra Betül Paksoy

Yayıncı:

Istanbul University

Ana Başlıklar:

Otorhinolaryngology | Clinical Sciences (Other)

Dergi:

The Turkish Journal of Ear Nose and Throat Vol.35 Issue 3, pp.149-154

Belge Tipi:

Makale

Yayın Tarihi:

9/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001360097

pISSN:

2602-4837

Loss of smell

chronic rhinosinusitis

nasal polyp

systemic immune0inflammatory index

sniffin sticks

Sayı

Makale detayları

Relationship Between Serum Inflammatory Markers and Olfactory Function in Polypoid and Non-Polypoid Chronic Rhinosinusitis

Yazarlar: Ali Amca | Elvan Evrim Tuna | Melih Çayönü | Zehra Betül Paksoy

Yayıncı: Istanbul University

Ana Başlıklar: Otorhinolaryngology | Clinical Sciences (Other)

Dergi: The Turkish Journal of Ear Nose and Throat Vol.35 Issue 3, pp.149-154

Belge Tipi: Makale

Yayın Tarihi: 9/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001360097

pISSN: 2602-4837

Loss of smell

chronic rhinosinusitis

nasal polyp

systemic immune0inflammatory index

sniffin sticks

Sayı

Yazarlar:

Ali Amca | Elvan Evrim Tuna | Melih Çayönü | Zehra Betül Paksoy

Yayıncı:

Istanbul University

Ana Başlıklar:

Otorhinolaryngology | Clinical Sciences (Other)

Dergi:

The Turkish Journal of Ear Nose and Throat Vol.35 Issue 3, pp.149-154

Belge Tipi:

Makale

Yayın Tarihi:

9/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001360097

pISSN:

2602-4837