Histopathological Analysis of Seminomatous and Non-Seminomatous Germ Cell Tumors of the Testis

Neşe Yeldir; Aslı Çakır; Taha Cumhan Şavlı; Bahar Muezzinoglu

Makale detayları

Histopathological Analysis of Seminomatous and Non-Seminomatous Germ Cell Tumors of the Testis

Yazarlar:

Neşe Yeldir | Aslı Çakır | Taha Cumhan Şavlı | Bahar Muezzinoglu

Yayıncı:

Akdeniz University

Ana Başlıklar:

Patoloji | Üroloji

Dergi:

Akdeniz Tıp Dergisi Vol.11 Issue 3, pp.357-363

Belge Tipi:

Makale

Yayın Tarihi:

9/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001357303

pISSN:

2687-2781

Anahtar kelimeler:

Özet:

 Introduction: Approximately 90 of testicular tumors originate from germ cells. Tumor size, lymphovascular invasion, spermatic cord invasion, epididymal invasion, tunica vaginalis and hilar soft tissue invasion are important parameters for staging and prognosis in germ cell tumors of the testis and these parameters are related to prognosis. Materials and methods: Therefore, 80 cases diagnosed with testicular germ cell tumors were retrospectively analyzed. The patients age, tumor size, invasion characteristics, tumor focus numbers, tumor subtypes and percentage amounts of the components were documented. Results: Of the cases, 40 50 were seminoma, 32 40 were mixed germ cell tumors, 6 7,5 were embryonal carcinomas and 2 2,5 were postpubertal type teratomas. Of these 80 cases, 48,75 had rete testicular invasion, 5 had epididymal invasion, 18,75 had hilar soft tissue invasion, 10 had spermatic cord invasion, 52,5 had lymphovascular invasion, 3,75 had tunica vaginalis invasion and 2,5 had spermatic cord surgical margin invasion. A statistically significant correlation was found between tumor size and all invasion sites. The correlation between yolk sac tumor component and epididymis, hilar soft tissue, spermatic cord and lymphovascular invasions was found to be significant. There was also a statistically significant correlation between embryonal carcinoma component and epididymis and spermatic cord invasions. Conclusion: It is important to evaluate macroscopically and microscopically the tumor size and invasion sites is which are determinants of prognosis in germ cell tumors of the testis. Additionally, it should be kept in mind that tumor subtypes may also be a factor determining the extent and site of invasion.

 Introduction: Approximately 90 of testicular tumors originate from germ cells. Tumor size, lymphovascular invasion, spermatic cord invasion, epididymal invasion, tunica vaginalis and hilar soft tissue invasion are important parameters for staging and prognosis in germ cell tumors of the testis and these parameters are related to prognosis. Materials and methods: Therefore, 80 cases diagnosed with testicular germ cell tumors were retrospectively analyzed. The patients age, tumor size, invasion characteristics, tumor focus numbers, tumor subtypes and percentage amounts of the components were documented. Results: Of the cases, 40 50 were seminoma, 32 40 were mixed germ cell tumors, 6 7,5 were embryonal carcinomas and 2 2,5 were postpubertal type teratomas. Of these 80 cases, 48,75 had rete testicular invasion, 5 had epididymal invasion, 18,75 had hilar soft tissue invasion, 10 had spermatic cord invasion, 52,5 had lymphovascular invasion, 3,75 had tunica vaginalis invasion and 2,5 had spermatic cord surgical margin invasion. A statistically significant correlation was found between tumor size and all invasion sites. The correlation between yolk sac tumor component and epididymis, hilar soft tissue, spermatic cord and lymphovascular invasions was found to be significant. There was also a statistically significant correlation between embryonal carcinoma component and epididymis and spermatic cord invasions. Conclusion: It is important to evaluate macroscopically and microscopically the tumor size and invasion sites is which are determinants of prognosis in germ cell tumors of the testis. Additionally, it should be kept in mind that tumor subtypes may also be a factor determining the extent and site of invasion.

 Introduction: Approximately 90 of testicular tumors originate from germ cells. Tumor size, lymphovascular invasion, spermatic cord invasion, epididymal invasion, tunica vaginalis and hilar soft tissue invasion are important parameters for staging and prognosis in germ cell tumors of the testis and these parameters are related to prognosis. Materials and methods: Therefore, 80 cases diagnosed with testicular germ cell tumors were retrospectively analyzed. The patients age, tumor size, invasion characteristics, tumor focus numbers, tumor subtypes and percentage amounts of the components were documented. Results: Of the cases, 40 50 were seminoma, 32 40 were mixed germ cell tumors, 6 7,5 were embryonal carcinomas and 2 2,5 were postpubertal type teratomas. Of these 80 cases, 48,75 had rete testicular invasion, 5 had epididymal invasion, 18,75 had hilar soft tissue invasion, 10 had spermatic cord invasion, 52,5 had lymphovascular invasion, 3,75 had tunica vaginalis invasion and 2,5 had spermatic cord surgical margin invasion. A statistically significant correlation was found between tumor size and all invasion sites. The correlation between yolk sac tumor component and epididymis, hilar soft tissue, spermatic cord and lymphovascular invasions was found to be significant. There was also a statistically significant correlation between embryonal carcinoma component and epididymis and spermatic cord invasions. Conclusion: It is important to evaluate macroscopically and microscopically the tumor size and invasion sites is which are determinants of prognosis in germ cell tumors of the testis. Additionally, it should be kept in mind that tumor subtypes may also be a factor determining the extent and site of invasion.

 Giriş: : Testis tümörlerinin yaklaşık 90ı germ hücrelerinden köken alır. Germ hücreli tümörlerde tümör boyutu, lenfovasküler invazyon, spermatik kord invazyonu, epididim invazyonu, tunika vajinalis ve hiler yumuşak doku invazyonu evreleme için önemli parametrelerdir ve bu parametreler prognozla ilişkilidir. Materyal ve method: Testis germ hücreli tümör tanılı 80 olgu retrospektif olarak analiz edildi. Hastalar yaş, tümör boyutu, invazyon özellikleri, tümör odaklarının sayısı, tümör alttipleri ve komponentlerin oranları kayıt edildi. Sonuçlar: Olguların, 40ı 50 seminom, 32si 40 mikst germ hücreli tümör, 6sı 7,5 embriyonal karsinom and 2si 2,5 postpubertal tip teratom. 80 olgunun, 48,75inde rete testis invazyonu, 5inde epididim invazyonu, 18,75inde hiler yumuşak doku invazyonu, 10unda spermatik kord invazyonu, 52,5inde lenfovasküler invazyon, 3,75inde tunika vajinalis invazyonu ve 2,5inde spermatik kord cerrahi sınır invazyonu vardı. Tümör boyutu ve bütün invazyonlar arasında istatistiksel olarak anlamlı bir ilişki saptandı. Yolk sak tümör komponenti ile epididim, hiler yumuşak doku, spermatik kord ve lenfovasküler invazyon arasındaki ilişki de istatistiksel olarak anlamlı bulundu. Ayrıca embriyonal karsinom komponenti ile epididim ve spermatik kord invazyonu arasındaki ilişki de istatistiksel olarak anlamlı bulundu. Tartışma: Testisin germ hücreli tümörlerinde makroskobik değerlendirme ve mikroskobik tümör boyutu ve invazyon alanları prognozu belirlemede önemlidir. Ek olarak, Tümör alttiplerinin de tümörün yayılımını belirlemek için bir faktör olabileceği akılda bulundurulmalıdır.

Makale detayları

Histopathological Analysis of Seminomatous and Non-Seminomatous Germ Cell Tumors of the Testis

Yazarlar:

Neşe Yeldir | Aslı Çakır | Taha Cumhan Şavlı | Bahar Muezzinoglu

Yayıncı:

Akdeniz University

Ana Başlıklar:

Patoloji | Üroloji

Dergi:

Akdeniz Tıp Dergisi Vol.11 Issue 3, pp.357-363

Belge Tipi:

Makale

Yayın Tarihi:

9/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001357303

pISSN:

2687-2781

Germ cell tumor

seminoma

pathological stage

testicular tumor

tumor size

invasiongerm hücreli tümör

seminom

patolojik evre

testis tümörü

tümör boyutu

invazyon

Sayı

Makale detayları

Yazarlar: Neşe Yeldir | Aslı Çakır | Taha Cumhan Şavlı | Bahar Muezzinoglu

Yayıncı: Akdeniz University

Ana Başlıklar: Patoloji | Üroloji

Dergi: Akdeniz Tıp Dergisi Vol.11 Issue 3, pp.357-363

Belge Tipi: Makale

Yayın Tarihi: 9/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001357303

pISSN: 2687-2781

Sayı

Yazarlar:

Neşe Yeldir | Aslı Çakır | Taha Cumhan Şavlı | Bahar Muezzinoglu

Yayıncı:

Akdeniz University

Ana Başlıklar:

Patoloji | Üroloji

Dergi:

Akdeniz Tıp Dergisi Vol.11 Issue 3, pp.357-363

Belge Tipi:

Makale

Yayın Tarihi:

9/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001357303

pISSN:

2687-2781