Tianeptine exerts ameliorative effects on acetic acid-induced colitis as detected by anti-inflammatory and antioxidant markers in rats; the role of anti-LOX and radical scavenging activity

Dilek Özbeyli; Naziye Özkan Yenal; Meral Yüksel; Ali Şen; Aslı Aykaç

Makale detayları

Tianeptine exerts ameliorative effects on acetic acid-induced colitis as detected by anti-inflammatory and antioxidant markers in rats; the role of anti-LOX and radical scavenging activity

Yazarlar:

Dilek Özbeyli | Naziye Özkan Yenal | Meral Yüksel | Ali Şen | Aslı Aykaç

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmacology and Pharmaceutical Sciences (Other)

Dergi:

Journal of Research in Pharmacy Vol.29 Issue 3, pp.1017-1027

Belge Tipi:

Makale

Yayın Tarihi:

4/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001344605

pISSN:

2630-6344

Anahtar kelimeler:

Özet:

 Some patients with ulcerative colitis UC could benefit from antidepressant use, particularly when having concomitant depression or during the remission period. For this purpose, we investigated the therapeutic effects of Tianeptine TT on UC induced by acetic acid AA in rats from the perspective of both in vitro and in vivo antiinflammatory and antioxidant activity. Within the in vivo experiments, the rats were divided into control C, AA TT, and AA sulfasalazine AASS groups. Colitis was induced with the application of AA 5 intrarectally. Compared to indomethacin 21.42 μgml, SS showed an equally strong anti-inflammatory activity 21.97 μgml, while Tianeptine had a good anti-LOX activity 88.57 μgml in vitro. Compared to standard Trolox 13 μgml against ABTS radical, Tianeptine 238.60 μgml and sulfasalazine 1727 μgml showed free radical scavenging activity in vitro. AA caused a depletion in colonic GSH p0.001 and an increase in MDA, MPO, luminol, and lucigenin chemiluminescence levels p0.01- p0.001 compared with the C group. Macroscopic and microscopic scoring were elevated in the AA group p0.001. The AA TT and AA SS groups showed improvement in GSH, MDA, MPO, and CL levels compared to the AA group p0.01- p 0.001. Macroscopic and microscopic scoring decreased in the AA TT and AA SS groups p0.001 compared to the AA group. In conclusion, our study demonstrated that TT has a curative effect on UC based on its in vitro and in vivo anti-inflammatory and antioxidant activities. TT can be used in patients with concomitant colon inflammation and depression.

 Some patients with ulcerative colitis UC could benefit from antidepressant use, particularly when having concomitant depression or during the remission period. For this purpose, we investigated the therapeutic effects of Tianeptine TT on UC induced by acetic acid AA in rats from the perspective of both in vitro and in vivo antiinflammatory and antioxidant activity. Within the in vivo experiments, the rats were divided into control C, AA TT, and AA sulfasalazine AASS groups. Colitis was induced with the application of AA 5 intrarectally. Compared to indomethacin 21.42 μgml, SS showed an equally strong anti-inflammatory activity 21.97 μgml, while Tianeptine had a good anti-LOX activity 88.57 μgml in vitro. Compared to standard Trolox 13 μgml against ABTS radical, Tianeptine 238.60 μgml and sulfasalazine 1727 μgml showed free radical scavenging activity in vitro. AA caused a depletion in colonic GSH p0.001 and an increase in MDA, MPO, luminol, and lucigenin chemiluminescence levels p0.01- p0.001 compared with the C group. Macroscopic and microscopic scoring were elevated in the AA group p0.001. The AA TT and AA SS groups showed improvement in GSH, MDA, MPO, and CL levels compared to the AA group p0.01- p 0.001. Macroscopic and microscopic scoring decreased in the AA TT and AA SS groups p0.001 compared to the AA group. In conclusion, our study demonstrated that TT has a curative effect on UC based on its in vitro and in vivo anti-inflammatory and antioxidant activities. TT can be used in patients with concomitant colon inflammation and depression.

 Some patients with ulcerative colitis UC could benefit from antidepressant use, particularly when having concomitant depression or during the remission period. For this purpose, we investigated the therapeutic effects of Tianeptine TT on UC induced by acetic acid AA in rats from the perspective of both in vitro and in vivo antiinflammatory and antioxidant activity. Within the in vivo experiments, the rats were divided into control C, AA TT, and AA sulfasalazine AASS groups. Colitis was induced with the application of AA 5 intrarectally. Compared to indomethacin 21.42 μgml, SS showed an equally strong anti-inflammatory activity 21.97 μgml, while Tianeptine had a good anti-LOX activity 88.57 μgml in vitro. Compared to standard Trolox 13 μgml against ABTS radical, Tianeptine 238.60 μgml and sulfasalazine 1727 μgml showed free radical scavenging activity in vitro. AA caused a depletion in colonic GSH p0.001 and an increase in MDA, MPO, luminol, and lucigenin chemiluminescence levels p0.01- p0.001 compared with the C group. Macroscopic and microscopic scoring were elevated in the AA group p0.001. The AA TT and AA SS groups showed improvement in GSH, MDA, MPO, and CL levels compared to the AA group p0.01- p 0.001. Macroscopic and microscopic scoring decreased in the AA TT and AA SS groups p0.001 compared to the AA group. In conclusion, our study demonstrated that TT has a curative effect on UC based on its in vitro and in vivo anti-inflammatory and antioxidant activities. TT can be used in patients with concomitant colon inflammation and depression.

 Some patients with ulcerative colitis UC could benefit from antidepressant use, particularly when having concomitant depression or during the remission period. For this purpose, we investigated the therapeutic effects of Tianeptine TT on UC induced by acetic acid AA in rats from the perspective of both in vitro and in vivo antiinflammatory and antioxidant activity. Within the in vivo experiments, the rats were divided into control C, AA TT, and AA sulfasalazine AASS groups. Colitis was induced with the application of AA 5 intrarectally. Compared to indomethacin 21.42 μgml, SS showed an equally strong anti-inflammatory activity 21.97 μgml, while Tianeptine had a good anti-LOX activity 88.57 μgml in vitro. Compared to standard Trolox 13 μgml against ABTS radical, Tianeptine 238.60 μgml and sulfasalazine 1727 μgml showed free radical scavenging activity in vitro. AA caused a depletion in colonic GSH p0.001 and an increase in MDA, MPO, luminol, and lucigenin chemiluminescence levels p0.01- p0.001 compared with the C group. Macroscopic and microscopic scoring were elevated in the AA group p0.001. The AA TT and AA SS groups showed improvement in GSH, MDA, MPO, and CL levels compared to the AA group p0.01- p 0.001. Macroscopic and microscopic scoring decreased in the AA TT and AA SS groups p0.001 compared to the AA group. In conclusion, our study demonstrated that TT has a curative effect on UC based on its in vitro and in vivo anti-inflammatory and antioxidant activities. TT can be used in patients with concomitant colon inflammation and depression.

Makale detayları

Tianeptine exerts ameliorative effects on acetic acid-induced colitis as detected by anti-inflammatory and antioxidant markers in rats; the role of anti-LOX and radical scavenging activity

Yazarlar:

Dilek Özbeyli | Naziye Özkan Yenal | Meral Yüksel | Ali Şen | Aslı Aykaç

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmacology and Pharmaceutical Sciences (Other)

Dergi:

Journal of Research in Pharmacy Vol.29 Issue 3, pp.1017-1027

Belge Tipi:

Makale

Yayın Tarihi:

4/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001344605

pISSN:

2630-6344

Ulcerative colitis

Depression

Tianeptine

Anti-5-lipoxygenase

Anti-ABTS

MDA

MPO

GSH

Sayı

Makale detayları

Yazarlar: Dilek Özbeyli | Naziye Özkan Yenal | Meral Yüksel | Ali Şen | Aslı Aykaç

Yayıncı: Marmara University

Ana Başlıklar: Pharmacology and Pharmaceutical Sciences (Other)

Dergi: Journal of Research in Pharmacy Vol.29 Issue 3, pp.1017-1027

Belge Tipi: Makale

Yayın Tarihi: 4/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001344605

pISSN: 2630-6344

Sayı

Yazarlar:

Dilek Özbeyli | Naziye Özkan Yenal | Meral Yüksel | Ali Şen | Aslı Aykaç

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmacology and Pharmaceutical Sciences (Other)

Dergi:

Journal of Research in Pharmacy Vol.29 Issue 3, pp.1017-1027

Belge Tipi:

Makale

Yayın Tarihi:

4/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001344605

pISSN:

2630-6344