Demographic, Clinical and Laboratory Characteristics of Monitored Cases with Diabetes Diagnosis in Ordu Province and Its Surroundings: Is the Prevalence of Type 2 Diabetes Increasing in Children Due to Obesity?

Yavuz Özer; Ecem İpek Altınok

Makale detayları

Demographic, Clinical and Laboratory Characteristics of Monitored Cases with Diabetes Diagnosis in Ordu Province and Its Surroundings: Is the Prevalence of Type 2 Diabetes Increasing in Children Due to Obesity?

Yazarlar:

Yavuz Özer | Ecem İpek Altınok

Yayıncı:

Zonguldak Bulent Ecevit University

Ana Başlıklar:

Çocuk Endokrinolojisi

Dergi:

Türkiye Diyabet ve Obezite Dergisi Vol.8 Issue 1, pp.27-34

Belge Tipi:

Makale

Yayın Tarihi:

4/2024

Belge Dili:

Türkçe

Document ID (Org No.):

2001316559

pISSN:

2587-0335

Anahtar kelimeler:

Özet:

 Aim: This study aimed to evaluate the demographic, clinical and laboratory characteristics of children and adolescents diagnosed with diabetes mellitus in Ordu province and its surroundings. Material and Methods: The study was conducted by retrospectively examining the medical records of children and adolescents diagnosed with diabetes mellitus between April 2022 and March 2023. A total of 95 cases were grouped according to the types of diabetes mellitus. Age, gender, anthropometric measurements, pubertal status, age at diagnosis, referral methods, comorbidities, and laboratory findings were compared among these three groups. Kolmogorov-Smirnov test, Shapiro-Wilk Student t-test, Mann Whitney-U test, Kruskal Wallis test, Dwass-Steel-Critchlow-Fligner DSCF post-hoc analysis were used to analyze the data. Jamovi version 2.3.21 program was preferred for data analysis. A statistical significance level of p 0.05 was chosen for this study. Results: The study included 95 54 female, 61 pubertal childrenadolescents with a median age of 12.8 years who were diagnosed with diabetes and followed up. 69.5 n66 of the cases were type 1 diabetes T1D, 20 n19 were type 2 diabetes T2D and 10.5 n10 were monogenic diabetes MD. Out of eight cases diagnosed with monogenic diabetes, two had heterozygous mutations in the HNF1A gene, and six had them in the GCK gene. The median age at diagnosis was higher in T2D than in T1D and MD p0.001, p0.001. The presenting manifestations of all cases were: 44.2 n42 had hyperglycemia, 21.1 n20 had diabetic ketosis, and 34.7 n33 had diabetic ketoacidosis. The most common form of presentation at diagnosis was diabetic ketoacidosis 50 in T1D, while hyperglycemia 89.5 and 90, respectively in T2D and MD. Body weight-SDS and body mass index-SDS were higher in T2D than in T1D p0.001, p0.001 and MD p0.001, p0.003. HbA1c level at diagnosis was higher in T1D than in MD p0.001. While the insulin level at diagnosis was lower in T1D than in T2D and MD p0.001, p0.046, it was higher in T2D than in MD p0.003. C-peptide level at diagnosis was lower in T1D than in T2D and MD p0.001, p0.004. Conclusion: The prevalence of obesity and T2D is increasing. Its detection is important because it is an important public health problem. In addition to body mass index, HbA1c, insulin and C-peptide levels at the time of diagnosis help determine the type of diabetes.

 Aim: This study aimed to evaluate the demographic, clinical and laboratory characteristics of children and adolescents diagnosed with diabetes mellitus in Ordu province and its surroundings. Material and Methods: The study was conducted by retrospectively examining the medical records of children and adolescents diagnosed with diabetes mellitus between April 2022 and March 2023. A total of 95 cases were grouped according to the types of diabetes mellitus. Age, gender, anthropometric measurements, pubertal status, age at diagnosis, referral methods, comorbidities, and laboratory findings were compared among these three groups. Kolmogorov-Smirnov test, Shapiro-Wilk Student t-test, Mann Whitney-U test, Kruskal Wallis test, Dwass-Steel-Critchlow-Fligner DSCF post-hoc analysis were used to analyze the data. Jamovi version 2.3.21 program was preferred for data analysis. A statistical significance level of p 0.05 was chosen for this study. Results: The study included 95 54 female, 61 pubertal childrenadolescents with a median age of 12.8 years who were diagnosed with diabetes and followed up. 69.5 n66 of the cases were type 1 diabetes T1D, 20 n19 were type 2 diabetes T2D and 10.5 n10 were monogenic diabetes MD. Out of eight cases diagnosed with monogenic diabetes, two had heterozygous mutations in the HNF1A gene, and six had them in the GCK gene. The median age at diagnosis was higher in T2D than in T1D and MD p0.001, p0.001. The presenting manifestations of all cases were: 44.2 n42 had hyperglycemia, 21.1 n20 had diabetic ketosis, and 34.7 n33 had diabetic ketoacidosis. The most common form of presentation at diagnosis was diabetic ketoacidosis 50 in T1D, while hyperglycemia 89.5 and 90, respectively in T2D and MD. Body weight-SDS and body mass index-SDS were higher in T2D than in T1D p0.001, p0.001 and MD p0.001, p0.003. HbA1c level at diagnosis was higher in T1D than in MD p0.001. While the insulin level at diagnosis was lower in T1D than in T2D and MD p0.001, p0.046, it was higher in T2D than in MD p0.003. C-peptide level at diagnosis was lower in T1D than in T2D and MD p0.001, p0.004. Conclusion: The prevalence of obesity and T2D is increasing. Its detection is important because it is an important public health problem. In addition to body mass index, HbA1c, insulin and C-peptide levels at the time of diagnosis help determine the type of diabetes.

 Aim: This study aimed to evaluate the demographic, clinical and laboratory characteristics of children and adolescents diagnosed with diabetes mellitus in Ordu province and its surroundings. Material and Methods: The study was conducted by retrospectively examining the medical records of children and adolescents diagnosed with diabetes mellitus between April 2022 and March 2023. A total of 95 cases were grouped according to the types of diabetes mellitus. Age, gender, anthropometric measurements, pubertal status, age at diagnosis, referral methods, comorbidities, and laboratory findings were compared among these three groups. Kolmogorov-Smirnov test, Shapiro-Wilk Student t-test, Mann Whitney-U test, Kruskal Wallis test, Dwass-Steel-Critchlow-Fligner DSCF post-hoc analysis were used to analyze the data. Jamovi version 2.3.21 program was preferred for data analysis. A statistical significance level of p 0.05 was chosen for this study. Results: The study included 95 54 female, 61 pubertal childrenadolescents with a median age of 12.8 years who were diagnosed with diabetes and followed up. 69.5 n66 of the cases were type 1 diabetes T1D, 20 n19 were type 2 diabetes T2D and 10.5 n10 were monogenic diabetes MD. Out of eight cases diagnosed with monogenic diabetes, two had heterozygous mutations in the HNF1A gene, and six had them in the GCK gene. The median age at diagnosis was higher in T2D than in T1D and MD p0.001, p0.001. The presenting manifestations of all cases were: 44.2 n42 had hyperglycemia, 21.1 n20 had diabetic ketosis, and 34.7 n33 had diabetic ketoacidosis. The most common form of presentation at diagnosis was diabetic ketoacidosis 50 in T1D, while hyperglycemia 89.5 and 90, respectively in T2D and MD. Body weight-SDS and body mass index-SDS were higher in T2D than in T1D p0.001, p0.001 and MD p0.001, p0.003. HbA1c level at diagnosis was higher in T1D than in MD p0.001. While the insulin level at diagnosis was lower in T1D than in T2D and MD p0.001, p0.046, it was higher in T2D than in MD p0.003. C-peptide level at diagnosis was lower in T1D than in T2D and MD p0.001, p0.004. Conclusion: The prevalence of obesity and T2D is increasing. Its detection is important because it is an important public health problem. In addition to body mass index, HbA1c, insulin and C-peptide levels at the time of diagnosis help determine the type of diabetes.

 Amaç: Ordu ili ve çevresindeki diyabet mellitus tanısı ile takip edilen çocuk ve ergenlerin demografik, klinik ve laboratuvar özelliklerinin değerlendirilmesi amaçlandı. Gereç ve Yöntemler: Çalışma, Nisan 2022 ve Mart 2023 tarihleri arasında diabetes mellitus tanısı ile takip edilen çocuk ve ergenlerin, tıbbi kayıtlarının retrospektif olarak incelenmesi ile gerçekleştirildi. Toplamda 95 olgu diabetes mellitus tiplerine göre gruplandırıldı. Yaş, cinsiyet, vücut ölçümleri, pubertal durum, tanı yaşı, başvuru şekilleri, eşlik eden hastalıklar ve laboratuvar bulguları bu üç grup arasında karşılaştırıldı. Verilerin analizinde Kolmogorov-Smirnov testi, Shapiro-Wilk Student t-testi, Mann Whitney-U testi, Kruskal Wallis testi, Dwass-Steel-Critchlow-Fligner DSCF post-hoc analizi kulanılmıştır. Verilerin analizinde Jamovi version 2.3.21 programı kullanıldı. p 0,05 değeri istatistiksel olarak anlamlı kabul edildi. Bulgular: Çalışmaya diabet mellitus tanısı ile takip edilen ortanca yaşları 12,8 yıl olan 95 54 kız, 61 pubertal çocukergen dahil edildi. Olguların 69,5i n66 tip 1 diyabet T1D, 20si n19 tip 2 diyabet T2D ve 10,5i n10 monogenik diyabet MD tanısı ile takip edilmekte idi. Monogenik diyabet tanısı ile takipli olan iki hastada HFN1A, altı hastada GCK geninde heterozigot mutasyon vardı. Ortanca tanı yaşı T2Dde diğerlerine göre daha yüksekti p0.001. Tüm olguların 44,2si n42 hiperglisemi, 21,1i n20 diyabetik ketoz ve 34,7 n33 diyabetik ketoasidoz tablosunda başvurmuştu. Tanı anında en sık başvuru şekli T1Dde diyabetik ketoasidoz 50, T2D ve MDde hiperglisemi 89,5, 90 idi. Vücut ağırlığı-SDSsi ve vücut kütle indeksi-SDSsi T2Dde T1Dye p0,001, p0,001 ve MDye p0,001, p0.003 göre daha yüksekti. Tanı anındaki HbA1c düzeyi T1Dde MDye göre daha yüksek p0,001, insülin düzeyi T2Dye ve MDye göre daha düşük idi p0,001 ve p0,046, sırasıyla. T2Dde ise insülin düzeyi MDye göre daha yüksek bulundu p0,003. Tanı anındaki C-peptid düzeyi T1Dde T2D ve MDden daha düşüktü p0,001, p0,004. Sonuç: Obezite ve T2D sıklığı giderek artmaktadır. Önemli bir halk sağlığı sorunu olması nedeniyle tespiti önem taşımaktadır. Vücut kütle indeksinin yanında, tanı anındaki HbA1c, insülin ve C-peptid düzeyleri diyabetin tipinin belirlenmesinde yardımcı olmaktadır.

Makale detayları

Demographic, Clinical and Laboratory Characteristics of Monitored Cases with Diabetes Diagnosis in Ordu Province and Its Surroundings: Is the Prevalence of Type 2 Diabetes Increasing in Children Due to Obesity?

Yazarlar:

Yavuz Özer | Ecem İpek Altınok

Yayıncı:

Zonguldak Bulent Ecevit University

Ana Başlıklar:

Çocuk Endokrinolojisi

Dergi:

Türkiye Diyabet ve Obezite Dergisi Vol.8 Issue 1, pp.27-34

Belge Tipi:

Makale

Yayın Tarihi:

4/2024

Belge Dili:

Türkçe

Document ID (Org No.):

2001316559

pISSN:

2587-0335

Child

Adolescent

Type 1 diabetes

Type 2 diabetes

Monogenic diabetes

PrevalenceÇocuk

Ergen

Tip 1 diyabet

Tip 2 diyabet

Monogenik diyabet

Prevalans

Sayı

Makale detayları

Yazarlar: Yavuz Özer | Ecem İpek Altınok

Yayıncı: Zonguldak Bulent Ecevit University

Ana Başlıklar: Çocuk Endokrinolojisi

Dergi: Türkiye Diyabet ve Obezite Dergisi Vol.8 Issue 1, pp.27-34

Belge Tipi: Makale

Yayın Tarihi: 4/2024

Belge Dili: Türkçe

Document ID (Org No.): 2001316559

pISSN: 2587-0335

Sayı

Yazarlar:

Yavuz Özer | Ecem İpek Altınok

Yayıncı:

Zonguldak Bulent Ecevit University

Ana Başlıklar:

Çocuk Endokrinolojisi

Dergi:

Türkiye Diyabet ve Obezite Dergisi Vol.8 Issue 1, pp.27-34

Belge Tipi:

Makale

Yayın Tarihi:

4/2024

Belge Dili:

Türkçe

Document ID (Org No.):

2001316559

pISSN:

2587-0335