The second step in vitro trial of Ankaferd® Bloodstopper®: comparison with other hemostatic agents

Emre HURİ; Kadir Turgay AKGÜL; Mehmet Özgür YÜCEL; Hesna Müzeyyen ASTARCI; Hüseyin ÜSTÜN; Rüştü Cankon GERMİYANOĞLU

Makale detayları

The second step in vitro trial of Ankaferd® Bloodstopper®: comparison with other hemostatic agents

Yazarlar:

Emre HURİ | Kadir Turgay AKGÜL | Mehmet Özgür YÜCEL | Hesna Müzeyyen ASTARCI | Hüseyin ÜSTÜN | Rüştü Cankon GERMİYANOĞLU

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2011 Vol.41 Issue 1, pp.7-15

Belge Tipi:

Makale

Yayın Tarihi:

12/2010

Belge Dili:

Türkçe

Document ID (Org No.):

2000754811

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Anahtar kelimeler:

Özet:

 

To investigate the efficacy of Ankaferd Bloodstopper (ABS) and compare ABS with the other hemostatic agents still used in urologic surgery.  Materials and methods: Forty Wistar rats were divided into 5 groups: Group T (traditional), partial nephrectomy (PN) with hilar control as per the conventional technique; Group G (Glubran 2), conventional PN followed by the application of Glubran 2; Group F (FloSeal), FloSeal application to the resected area of the kidney; Group C (Celox), Celox was applied; Group A (ABS), Ankaferd was used. Warm ischemia time (WIT) and hemostasis time (HT) were recorded and histopathologic features were compared among the groups.    Results: In Group A, a significant decrease in WIT was detected while the difference was significant (P < 0.001). Statistical analysis confirmed that the evaluation of HT (in seconds) returned similar results to those seen in WITs among all groups. In Group A, decreased HT was confirmed in comparison to Group T while HT increased in comparison to the other groups (G, C, and F) (P < 0.001). Increased fibrosis and adhesion were shown in Group F while significant erythrocyte aggregation and microvascular proliferation were observed in Groups G, F, and A (P < 0.001).  Conclusion: A novel hemostatic agent, ABS, is as effective as other licensed hemostatic agents with comparable WIT and HT and better results in terms of histopathologic findings.

 

To investigate the efficacy of Ankaferd Bloodstopper (ABS) and compare ABS with the other hemostatic agents still used in urologic surgery.  Materials and methods: Forty Wistar rats were divided into 5 groups: Group T (traditional), partial nephrectomy (PN) with hilar control as per the conventional technique; Group G (Glubran 2), conventional PN followed by the application of Glubran 2; Group F (FloSeal), FloSeal application to the resected area of the kidney; Group C (Celox), Celox was applied; Group A (ABS), Ankaferd was used. Warm ischemia time (WIT) and hemostasis time (HT) were recorded and histopathologic features were compared among the groups.    Results: In Group A, a significant decrease in WIT was detected while the difference was significant (P < 0.001). Statistical analysis confirmed that the evaluation of HT (in seconds) returned similar results to those seen in WITs among all groups. In Group A, decreased HT was confirmed in comparison to Group T while HT increased in comparison to the other groups (G, C, and F) (P < 0.001). Increased fibrosis and adhesion were shown in Group F while significant erythrocyte aggregation and microvascular proliferation were observed in Groups G, F, and A (P < 0.001).  Conclusion: A novel hemostatic agent, ABS, is as effective as other licensed hemostatic agents with comparable WIT and HT and better results in terms of histopathologic findings.

Makale detayları

The second step in vitro trial of Ankaferd® Bloodstopper®: comparison with other hemostatic agents

Yazarlar:

Emre HURİ | Kadir Turgay AKGÜL | Mehmet Özgür YÜCEL | Hesna Müzeyyen ASTARCI | Hüseyin ÜSTÜN | Rüştü Cankon GERMİYANOĞLU

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2011 Vol.41 Issue 1, pp.7-15

Belge Tipi:

Makale

Yayın Tarihi:

12/2010

Belge Dili:

Türkçe

Document ID (Org No.):

2000754811

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Key words: Hemostatic agents

hemostasis

comparison

partial nephrectomy

Sayı

Makale detayları

The second step in vitro trial of Ankaferd® Bloodstopper®: comparison with other hemostatic agents

Yazarlar: Emre HURİ | Kadir Turgay AKGÜL | Mehmet Özgür YÜCEL | Hesna Müzeyyen ASTARCI | Hüseyin ÜSTÜN | Rüştü Cankon GERMİYANOĞLU

Yayıncı: TUBITAK

Dergi: Turkish Journal of Medical Sciences 2011 Vol.41 Issue 1, pp.7-15

Belge Tipi: Makale

Yayın Tarihi: 12/2010

Belge Dili: Türkçe

Document ID (Org No.): 2000754811

Sıklık: İki Aylık

eISSN: 1303-6165

pISSN: 1300-0144

Key words: Hemostatic agents

hemostasis

comparison

partial nephrectomy

Sayı

Yazarlar:

Emre HURİ | Kadir Turgay AKGÜL | Mehmet Özgür YÜCEL | Hesna Müzeyyen ASTARCI | Hüseyin ÜSTÜN | Rüştü Cankon GERMİYANOĞLU

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2011 Vol.41 Issue 1, pp.7-15

Belge Tipi:

Makale

Yayın Tarihi:

12/2010

Belge Dili:

Türkçe

Document ID (Org No.):

2000754811

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144