Evaluation of Pro-Drug Properties in a Novel Schiff Base-Incorporated Pt(II) Complex

Salih Günnaz; Khan Mohammad Rahmat; Sevil İrişli

Makale detayları

Evaluation of Pro-Drug Properties in a Novel Schiff Base-Incorporated Pt(II) Complex

Yazarlar:

Salih Günnaz | Khan Mohammad Rahmat | Sevil İrişli

Yayıncı:

Erzincan Binali Yildirim University

Ana Başlıklar:

İnorganik Yeşil Kimya

Dergi:

Erzincan Üniversitesi Fen Bilimleri Enstitüsü Dergisi Vol.17 Issue 2, pp.410-425

Belge Tipi:

Makale

Yayın Tarihi:

8/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001325575

pISSN:

2149-4584

Anahtar kelimeler:

Özet:

 The present investigation involved the synthesis of a new Schiff base and its platinum complex. The chemical structures of both the ligand and the complex were determined through the utilization of various analytical techniques, including 1H-NMR, 13C-NMR, FT-IR, and elemental analysis. Moreover, the interaction between the synthesized complex and Amyloid-Beta, a crucial factor in the pathogenesis of Alzheimers disease, was explored. This interaction was assessed by means of fluorescence spectrophotometry. Additionally, the influence of the histidine amino acid, which has been reported in the literature to play a significant role in the interaction between Amyloid-Beta and coordination compounds, was monitored using 1H-NMR. These investigations have the potential to enhance our comprehension of the chemical structure and biological effects of ligands and complexes. Furthermore, they may contribute to the advancement of knowledge regarding important neurodegenerative disorders such as Alzheimers disease, as well as the development of potential therapeutic strategies.

 The present investigation involved the synthesis of a new Schiff base and its platinum complex. The chemical structures of both the ligand and the complex were determined through the utilization of various analytical techniques, including 1H-NMR, 13C-NMR, FT-IR, and elemental analysis. Moreover, the interaction between the synthesized complex and Amyloid-Beta, a crucial factor in the pathogenesis of Alzheimers disease, was explored. This interaction was assessed by means of fluorescence spectrophotometry. Additionally, the influence of the histidine amino acid, which has been reported in the literature to play a significant role in the interaction between Amyloid-Beta and coordination compounds, was monitored using 1H-NMR. These investigations have the potential to enhance our comprehension of the chemical structure and biological effects of ligands and complexes. Furthermore, they may contribute to the advancement of knowledge regarding important neurodegenerative disorders such as Alzheimers disease, as well as the development of potential therapeutic strategies.

 The present investigation involved the synthesis of a new Schiff base and its platinum complex. The chemical structures of both the ligand and the complex were determined through the utilization of various analytical techniques, including 1H-NMR, 13C-NMR, FT-IR, and elemental analysis. Moreover, the interaction between the synthesized complex and Amyloid-Beta, a crucial factor in the pathogenesis of Alzheimers disease, was explored. This interaction was assessed by means of fluorescence spectrophotometry. Additionally, the influence of the histidine amino acid, which has been reported in the literature to play a significant role in the interaction between Amyloid-Beta and coordination compounds, was monitored using 1H-NMR. These investigations have the potential to enhance our comprehension of the chemical structure and biological effects of ligands and complexes. Furthermore, they may contribute to the advancement of knowledge regarding important neurodegenerative disorders such as Alzheimers disease, as well as the development of potential therapeutic strategies.

 The present investigation involved the synthesis of a new Schiff base and its platinum complex. The chemical structures of both the ligand and the complex were determined through the utilization of various analytical techniques, including 1H-NMR, 13C-NMR, FT-IR, and elemental analysis. Moreover, the interaction between the synthesized complex and Amyloid-Beta, a crucial factor in the pathogenesis of Alzheimers disease, was explored. This interaction was assessed by means of fluorescence spectrophotometry. Additionally, the influence of the histidine amino acid, which has been reported in the literature to play a significant role in the interaction between Amyloid-Beta and coordination compounds, was monitored using 1H-NMR. These investigations have the potential to enhance our comprehension of the chemical structure and biological effects of ligands and complexes. Furthermore, they may contribute to the advancement of knowledge regarding important neurodegenerative disorders such as Alzheimers disease, as well as the development of potential therapeutic strategies.

Makale detayları

Evaluation of Pro-Drug Properties in a Novel Schiff Base-Incorporated Pt(II) Complex

Yazarlar:

Salih Günnaz | Khan Mohammad Rahmat | Sevil İrişli

Yayıncı:

Erzincan Binali Yildirim University

Ana Başlıklar:

İnorganik Yeşil Kimya

Dergi:

Erzincan Üniversitesi Fen Bilimleri Enstitüsü Dergisi Vol.17 Issue 2, pp.410-425

Belge Tipi:

Makale

Yayın Tarihi:

8/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001325575

pISSN:

2149-4584

Alzheimer

Amyloid Beta

Platinum Complexes

Schiff Bases

Sayı

Makale detayları

Evaluation of Pro-Drug Properties in a Novel Schiff Base-Incorporated Pt(II) Complex

Yazarlar: Salih Günnaz | Khan Mohammad Rahmat | Sevil İrişli

Yayıncı: Erzincan Binali Yildirim University

Ana Başlıklar: İnorganik Yeşil Kimya

Dergi: Erzincan Üniversitesi Fen Bilimleri Enstitüsü Dergisi Vol.17 Issue 2, pp.410-425

Belge Tipi: Makale

Yayın Tarihi: 8/2024

Belge Dili: İngilizce

Document ID (Org No.): 2001325575

pISSN: 2149-4584

Alzheimer

Amyloid Beta

Platinum Complexes

Schiff Bases

Sayı

Yazarlar:

Salih Günnaz | Khan Mohammad Rahmat | Sevil İrişli

Yayıncı:

Erzincan Binali Yildirim University

Ana Başlıklar:

İnorganik Yeşil Kimya

Dergi:

Erzincan Üniversitesi Fen Bilimleri Enstitüsü Dergisi Vol.17 Issue 2, pp.410-425

Belge Tipi:

Makale

Yayın Tarihi:

8/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001325575

pISSN:

2149-4584