Investigation of the effect of combined use of alloplastic-based tricalcium phosphate  bone graft and antihemorrhagic plant extract (ABS) on bone regeneration in surgically  induced bone defects in nondiabetic rats: an experimental animal study

Abdulsamet TANIK; Arzum GÜLER DOĞRU; Veysi AKPOLAT; Filiz ACUN KAYA; Ebru SARIBAŞ; Mehmet GÜL; Sevgi İRTEGÜN KANDEMİR; Engin DEVECİ

Makale detayları

Investigation of the effect of combined use of alloplastic-based tricalcium phosphate bone graft and antihemorrhagic plant extract (ABS) on bone regeneration in surgically induced bone defects in nondiabetic rats: an experimental animal study

Yazarlar:

Abdulsamet TANIK | Arzum GÜLER DOĞRU | Veysi AKPOLAT | Filiz ACUN KAYA | Ebru SARIBAŞ | Mehmet GÜL | Sevgi İRTEGÜN KANDEMİR | Engin DEVECİ

Yayıncı:

TUBITAK

Ana Başlıklar:

Sağlık teşvikleri

Dergi:

Turkish Journal of Medical Sciences 2018 Vol.48 Issue 6, pp.1302-1314

Belge Tipi:

Makale

Yayın Tarihi:

12/2018

Belge Dili:

İngilizce

Document ID (Org No.):

2000750506

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Özet:

 


                        Background/aim:
  In  this  experimental  study,  we  aimed  to  evaluate  the  late  period  effects  of  the  combination  of  Ankaferd  Blood  
Stopper (ABS), which has bone wound healing effects, and ß-tricalcium phosphate (TCP) on the regeneration of bone tissue through 
histopathological, immunohistochemical, and radiological (dual energy X-ray absorptiometry - DEXA) methods in nondiabetic rats.
Materials and methods:
 Sixty-four Wistar albino male rats were used. In the calvaria of the rats, a bone defect 7.0 mm in diameter was 
created. These rats were divided into 4 different groups. Group 1 was the control group without any treatment, a 0.125 mL B-TCP graft 
was applied to Group 2, a 0.125 mL ABS was applied to Group 3, and a 0.125 mL (ß-TCP + ABS) mixture was applied to group 4. Half 
of the rats were sacrificed on day 28 and the other half on day 56. Histopathological, immunohistochemical, and DEXA analyses of the 
specimens were performed after the experiment.
Results:
 As a result of the histopathological analysis, osteoblastic activity and new bone formation were found to be significantly higher 
in Group 2, Group 3, and Group 4 than the control group on day 28 (P  0.05). 
Conclusion: 
The use of both ß-TCP + ABS and only ABS had positive effects on wound healing and bone formation in nondiabetic rats.
                    

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Makale detayları

Investigation of the effect of combined use of alloplastic-based tricalcium phosphate bone graft and antihemorrhagic plant extract (ABS) on bone regeneration in surgically induced bone defects in nondiabetic rats: an experimental animal study

Yazarlar: Abdulsamet TANIK | Arzum GÜLER DOĞRU | Veysi AKPOLAT | Filiz ACUN KAYA | Ebru SARIBAŞ | Mehmet GÜL | Sevgi İRTEGÜN KANDEMİR | Engin DEVECİ

Yayıncı: TUBITAK

Ana Başlıklar: Sağlık teşvikleri

Dergi: Turkish Journal of Medical Sciences 2018 Vol.48 Issue 6, pp.1302-1314

Belge Tipi: Makale

Yayın Tarihi: 12/2018

Belge Dili: İngilizce

Document ID (Org No.): 2000750506

Sıklık: İki Aylık

eISSN: 1303-6165

pISSN: 1300-0144

Sayı

Yazarlar:

Abdulsamet TANIK | Arzum GÜLER DOĞRU | Veysi AKPOLAT | Filiz ACUN KAYA | Ebru SARIBAŞ | Mehmet GÜL | Sevgi İRTEGÜN KANDEMİR | Engin DEVECİ

Yayıncı:

TUBITAK

Ana Başlıklar:

Sağlık teşvikleri

Dergi:

Turkish Journal of Medical Sciences 2018 Vol.48 Issue 6, pp.1302-1314

Belge Tipi:

Makale

Yayın Tarihi:

12/2018

Belge Dili:

İngilizce

Document ID (Org No.):

2000750506

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144