Differential Effect of Glutathione Depletion on Glycogenolysis in Isolated Rat Hepatocytes Mediated by a-Adrenoceptor Agonists and Glucagon

Mukadder ATMACA; Jeffrey R. FRY

Makale detayları

Differential Effect of Glutathione Depletion on Glycogenolysis in Isolated Rat Hepatocytes Mediated by a-Adrenoceptor Agonists and Glucagon

Yazarlar:

Mukadder ATMACA | Jeffrey R. FRY

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2005 Vol.35 Issue 2, pp.71-74

Belge Tipi:

Makale

Yayın Tarihi:

1/2005

Belge Dili:

Türkçe

Document ID (Org No.):

2000756419

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Anahtar kelimeler:

Özet:

 

Glutathione (GSH) exerts a variety of cytoprotecive effects, but is readily depleted from cells under a variety of stressful stimuli. The impact of GSH depletion on receptor-mediated activity in rat hepatocytes has been studied with regard to glycogenolysis stimulated with a-adrenoceptor agonists or glucagon, which exert their actions through different signalling pathways. Depletion of GSH content (70%) by diethyl maleate had no effect on the redox status of the cells or on basal or glucagon-stimulated glycogenolysis, but significantly reduced the response to the a-adrenoceptor agonists adrenalin and phenylephrine. These results highlight the possible modulatory effects of GSH on receptor-mediated activity in hepatocytes.

 

Glutathione (GSH) exerts a variety of cytoprotecive effects, but is readily depleted from cells under a variety of stressful stimuli. The impact of GSH depletion on receptor-mediated activity in rat hepatocytes has been studied with regard to glycogenolysis stimulated with a-adrenoceptor agonists or glucagon, which exert their actions through different signalling pathways. Depletion of GSH content (70%) by diethyl maleate had no effect on the redox status of the cells or on basal or glucagon-stimulated glycogenolysis, but significantly reduced the response to the a-adrenoceptor agonists adrenalin and phenylephrine. These results highlight the possible modulatory effects of GSH on receptor-mediated activity in hepatocytes.

Makale detayları

Differential Effect of Glutathione Depletion on Glycogenolysis in Isolated Rat Hepatocytes Mediated by a-Adrenoceptor Agonists and Glucagon

Yazarlar:

Mukadder ATMACA | Jeffrey R. FRY

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2005 Vol.35 Issue 2, pp.71-74

Belge Tipi:

Makale

Yayın Tarihi:

1/2005

Belge Dili:

Türkçe

Document ID (Org No.):

2000756419

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

a-adrenoceptors

glucagon

glutathione

glycogenolysis

hepatocytes receptors

Sayı

Makale detayları

Differential Effect of Glutathione Depletion on Glycogenolysis in Isolated Rat Hepatocytes Mediated by a-Adrenoceptor Agonists and Glucagon

Yazarlar: Mukadder ATMACA | Jeffrey R. FRY

Yayıncı: TUBITAK

Dergi: Turkish Journal of Medical Sciences 2005 Vol.35 Issue 2, pp.71-74

Belge Tipi: Makale

Yayın Tarihi: 1/2005

Belge Dili: Türkçe

Document ID (Org No.): 2000756419

Sıklık: İki Aylık

eISSN: 1303-6165

pISSN: 1300-0144

a-adrenoceptors

glucagon

glutathione

glycogenolysis

hepatocytes receptors

Sayı

Yazarlar:

Mukadder ATMACA | Jeffrey R. FRY

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2005 Vol.35 Issue 2, pp.71-74

Belge Tipi:

Makale

Yayın Tarihi:

1/2005

Belge Dili:

Türkçe

Document ID (Org No.):

2000756419

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144