Protective Effect of Chlorogenic Acid Against Testicular Damage Induced By Glyphosate Isopropilamine in Rats

Ruhi Türkmen; Yavuz Osman Birdane; Orkun Atik; Hasan Hüseyin Demirel; Özay Güleş

Makale detayları

Protective Effect of Chlorogenic Acid Against Testicular Damage Induced By Glyphosate Isopropilamine in Rats

Yazarlar:

Ruhi Türkmen | Yavuz Osman Birdane | Orkun Atik | Hasan Hüseyin Demirel | Özay Güleş

Yayıncı:

Afyon Kocatepe University

Ana Başlıklar:

Veteriner Farmakoloji

Dergi:

Kocatepe Veteriner Dergisi Vol.17 Issue 4, pp.334-340

Belge Tipi:

Makale

Yayın Tarihi:

3/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001327146

pISSN:

1308-1594

Anahtar kelimeler:

Özet:

 The aim of this subchronic toxicity study was to determine the prophylactic effect of chlorogenic acid CGA on the histopathologic-histologic changes and oxidative stress induced by Glyphosate isopropylamine GLF-ISO in testicular tissues. A sum of 42 male Wistar rats were divided into six equal groups, each containing 7 rats. For pretreatment, rats were given CGA at doses of 12.5, 25 and 50 mgkg po and GLF-ISO at 787.85 mgkg po for 7 weeks. GLF-ISO significantly increased malondialdehyde levels while decreasing SOD and CAT activities and GSH levels in testicular tissues. On the contrary, these parameters were improved in CGA-treated groups. Furthermore, CGA ameliorated the histopathological and histological changes in testicular tissues induced by GLF-ISO in a dose-dependent manner. The results indicate that testicular damage caused by GLF-ISO can potentially be prevented or managed by CGA.

 The aim of this subchronic toxicity study was to determine the prophylactic effect of chlorogenic acid CGA on the histopathologic-histologic changes and oxidative stress induced by Glyphosate isopropylamine GLF-ISO in testicular tissues. A sum of 42 male Wistar rats were divided into six equal groups, each containing 7 rats. For pretreatment, rats were given CGA at doses of 12.5, 25 and 50 mgkg po and GLF-ISO at 787.85 mgkg po for 7 weeks. GLF-ISO significantly increased malondialdehyde levels while decreasing SOD and CAT activities and GSH levels in testicular tissues. On the contrary, these parameters were improved in CGA-treated groups. Furthermore, CGA ameliorated the histopathological and histological changes in testicular tissues induced by GLF-ISO in a dose-dependent manner. The results indicate that testicular damage caused by GLF-ISO can potentially be prevented or managed by CGA.

 The aim of this subchronic toxicity study was to determine the prophylactic effect of chlorogenic acid CGA on the histopathologic-histologic changes and oxidative stress induced by Glyphosate isopropylamine GLF-ISO in testicular tissues. A sum of 42 male Wistar rats were divided into six equal groups, each containing 7 rats. For pretreatment, rats were given CGA at doses of 12.5, 25 and 50 mgkg po and GLF-ISO at 787.85 mgkg po for 7 weeks. GLF-ISO significantly increased malondialdehyde levels while decreasing SOD and CAT activities and GSH levels in testicular tissues. On the contrary, these parameters were improved in CGA-treated groups. Furthermore, CGA ameliorated the histopathological and histological changes in testicular tissues induced by GLF-ISO in a dose-dependent manner. The results indicate that testicular damage caused by GLF-ISO can potentially be prevented or managed by CGA.

 Bu subkronik toksisite çalışmasının amacı, testis dokularında Glifosat izopropilamin GLF-ISO tarafından indüklenen histopatolojik-histolojik değişiklikler ve oksidatif stres üzerinde klorojenik asidin CGA profilaktik etkisini belirlemektir. Toplam 42 erkek Wistar sıçan, her biri 7 sıçan içeren altı eşit gruba ayrılmıştır. Ön muamele için sıçanlara 7 hafta boyunca 12.5, 25 ve 50 mgkg po dozlarında CGA ve 787.85 mgkg po dozunda GLF-ISO verilmiştir. GLF-ISO testis dokularında malondialdehit seviyelerini önemli ölçüde artırırken SOD ve CAT aktivitelerini ve GSH seviyelerini azaltmıştır. Aksine, bu parametreler CGA ile tedavi edilen gruplarda iyileşmiştir. Ayrıca, CGA, GLF-ISO tarafından indüklenen testis dokularındaki histopatolojik ve histolojik değişiklikleri doza bağlı bir şekilde iyileştirmiştir. Sonuçlar, GLF-ISOnun neden olduğu testis hasarının CGA ile potansiyel olarak önlenebileceğini veya yönetilebileceğini göstermektedir.

Makale detayları

Protective Effect of Chlorogenic Acid Against Testicular Damage Induced By Glyphosate Isopropilamine in Rats

Yazarlar:

Ruhi Türkmen | Yavuz Osman Birdane | Orkun Atik | Hasan Hüseyin Demirel | Özay Güleş

Yayıncı:

Afyon Kocatepe University

Ana Başlıklar:

Veteriner Farmakoloji

Dergi:

Kocatepe Veteriner Dergisi Vol.17 Issue 4, pp.334-340

Belge Tipi:

Makale

Yayın Tarihi:

3/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001327146

pISSN:

1308-1594

Glyphosate isopropilamine

Chlorogenic acid

Oxidative stress

Testicular damageGlyphosate İzopropilamin

Klorojenik asit

Oksidatif stres

Testiküler hasar

Sayı

Makale detayları

Yazarlar: Ruhi Türkmen | Yavuz Osman Birdane | Orkun Atik | Hasan Hüseyin Demirel | Özay Güleş

Yayıncı: Afyon Kocatepe University

Ana Başlıklar: Veteriner Farmakoloji

Dergi: Kocatepe Veteriner Dergisi Vol.17 Issue 4, pp.334-340

Belge Tipi: Makale

Yayın Tarihi: 3/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001327146

pISSN: 1308-1594

Sayı

Yazarlar:

Ruhi Türkmen | Yavuz Osman Birdane | Orkun Atik | Hasan Hüseyin Demirel | Özay Güleş

Yayıncı:

Afyon Kocatepe University

Ana Başlıklar:

Veteriner Farmakoloji

Dergi:

Kocatepe Veteriner Dergisi Vol.17 Issue 4, pp.334-340

Belge Tipi:

Makale

Yayın Tarihi:

3/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001327146

pISSN:

1308-1594