Serum S100B, NSE, and GRIA1 levels as neurological biomarkers in lead exposure

Esra Firat OĞUZ; Fatma Meriç YILMAZ; Engin TUTKUN; Ömer Hinç YILMAZ; Müjgan ERCAN; Sevilay SEZER

Makale detayları

Serum S100B, NSE, and GRIA1 levels as neurological biomarkers in lead exposure

Yazarlar:

Esra Firat OĞUZ | Fatma Meriç YILMAZ | Engin TUTKUN | Ömer Hinç YILMAZ | Müjgan ERCAN | Sevilay SEZER

Yayıncı:

TUBITAK

Ana Başlıklar:

Sağlık teşvikleri

Dergi:

Turkish Journal of Medical Sciences 2018 Vol.48 Issue 3, pp.449-454

Belge Tipi:

Makale

Yayın Tarihi:

5/2018

Belge Dili:

İngilizce

Document ID (Org No.):

2000750681

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Özet:

 

Background/aim: The central nervous system is one of the major targets in lead exposure. Biomarkers for the diagnosis and follow-up  of lead exposure have not been identified. In this study, serum S100B, neuron-specific enolase (NSE), and glutamate receptor 1 (GRIA1)  levels were determined as possible biomarkers for lead neurotoxicity.  Material and methods: Twenty-five subjects with chronic lead exposure and 25 controls were included in the study. NSE and S100B  were measured by electrochemiluminescence immunoassay with a Cobas E601 analyzer. GRIA1 levels were measured with an ELISA  kit using a quantitative sandwich enzyme immunoassay technique.  Results: GRIA1 levels were significantly higher in the lead exposure group than in the control group. No significant differences for NSE,  S100B, ALT, AST, or creatinine in sera were found between lead exposure and control groups.  Conclusion: Subjects with chronic lead exposure are found to have increased glutamate receptor levels and do not seem to have glial or  neuronal damage, which can be demonstrated with the elevation of NSE and S100B levels. GRIA1 levels might be used as a biomarker  for the neurotoxicity of lead.

Makale detayları

Serum S100B, NSE, and GRIA1 levels as neurological biomarkers in lead exposure

Yazarlar: Esra Firat OĞUZ | Fatma Meriç YILMAZ | Engin TUTKUN | Ömer Hinç YILMAZ | Müjgan ERCAN | Sevilay SEZER

Yayıncı: TUBITAK

Ana Başlıklar: Sağlık teşvikleri

Dergi: Turkish Journal of Medical Sciences 2018 Vol.48 Issue 3, pp.449-454

Belge Tipi: Makale

Yayın Tarihi: 5/2018

Belge Dili: İngilizce

Document ID (Org No.): 2000750681

Sıklık: İki Aylık

eISSN: 1303-6165

pISSN: 1300-0144

Sayı

Yazarlar:

Esra Firat OĞUZ | Fatma Meriç YILMAZ | Engin TUTKUN | Ömer Hinç YILMAZ | Müjgan ERCAN | Sevilay SEZER

Yayıncı:

TUBITAK

Ana Başlıklar:

Sağlık teşvikleri

Dergi:

Turkish Journal of Medical Sciences 2018 Vol.48 Issue 3, pp.449-454

Belge Tipi:

Makale

Yayın Tarihi:

5/2018

Belge Dili:

İngilizce

Document ID (Org No.):

2000750681

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144