S-Aroylmethyl N, N-Disubstituted  Dithiocarbamates With Antiparkinson Activity

Rahime ŞİMŞEK

Makale detayları

S-Aroylmethyl N, N-Disubstituted Dithiocarbamates With Antiparkinson Activity

Yazarlar:

Rahime ŞİMŞEK

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 1999 Vol.29 Issue 6, pp.627-630

Belge Tipi:

Makale

Yayın Tarihi:

5/1999

Belge Dili:

Türkçe

Document ID (Org No.):

2000757782

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Anahtar kelimeler:

Özet:

 

Seven S-aroylmethyl N,N-disubstituted dithiocarbamate derivatives have been synthesized and their effects on   oxotremorine induced tremor have been investigated on mice pretreated with the proparkinsonian drug haloperidol. While the compound 1f inhibited oxotremorine-induced tremors at doses of 50 mg/kg and 100 mg/kg levels, compounds 1a, 1c and 1e had this effect at the dose of 100 mg/kg. The compounds 1b, 1d and 1g had no effect on oxotremorine-induced tremors in mice. These results suggest that some of these derivatives have central antimuscarinic effects and antiparkinson activities.

 

Seven S-aroylmethyl N,N-disubstituted dithiocarbamate derivatives have been synthesized and their effects on   oxotremorine induced tremor have been investigated on mice pretreated with the proparkinsonian drug haloperidol. While the compound 1f inhibited oxotremorine-induced tremors at doses of 50 mg/kg and 100 mg/kg levels, compounds 1a, 1c and 1e had this effect at the dose of 100 mg/kg. The compounds 1b, 1d and 1g had no effect on oxotremorine-induced tremors in mice. These results suggest that some of these derivatives have central antimuscarinic effects and antiparkinson activities.

Makale detayları

S-Aroylmethyl N, N-Disubstituted Dithiocarbamates With Antiparkinson Activity

Yazarlar:

Rahime ŞİMŞEK

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 1999 Vol.29 Issue 6, pp.627-630

Belge Tipi:

Makale

Yayın Tarihi:

5/1999

Belge Dili:

Türkçe

Document ID (Org No.):

2000757782

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Dithiocarbamate

antiparkinson activity

Sayı

Makale detayları

S-Aroylmethyl N, N-Disubstituted Dithiocarbamates With Antiparkinson Activity

Yazarlar: Rahime ŞİMŞEK

Yayıncı: TUBITAK

Dergi: Turkish Journal of Medical Sciences 1999 Vol.29 Issue 6, pp.627-630

Belge Tipi: Makale

Yayın Tarihi: 5/1999

Belge Dili: Türkçe

Document ID (Org No.): 2000757782

Sıklık: İki Aylık

eISSN: 1303-6165

pISSN: 1300-0144

Dithiocarbamate

antiparkinson activity

Sayı

Yazarlar:

Rahime ŞİMŞEK

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 1999 Vol.29 Issue 6, pp.627-630

Belge Tipi:

Makale

Yayın Tarihi:

5/1999

Belge Dili:

Türkçe

Document ID (Org No.):

2000757782

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144