A syphilis screening survey on HIV-positive and HIV-negative pregnant women, with placental histopathological evaluation of reactive cases, in a hospital in Uyo, Southern Nigeria

Uchechukwu Brian Eziagu

Makale detayları

A syphilis screening survey on HIV-positive and HIV-negative pregnant women, with placental histopathological evaluation of reactive cases, in a hospital in Uyo, Southern Nigeria

Yazarlar:

Uchechukwu Brian Eziagu

Yayıncı:

Dicle University

Ana Başlıklar:

Sağlık Kurumları Yönetimi

Dergi:

Dicle Tıp Dergisi Vol.50 Issue 1, pp.1-13

Belge Tipi:

Makale

Yayın Tarihi:

3/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001285391

pISSN:

1300-2945

Anahtar kelimeler:

Özet:

 Objectives: Veneral Disease Research Laboratory VDRL test is an important screening tool for syphilis in pregnancy because of adverse pregnancy outcomes, particularly congenital syphilis CS and can be combined with the placental histopathological examination in the diagnosis of CS. Thus, we aimed to compare VDRL test results from HIV-positiveHIV-negative pregnant women with relevant historical data and perinatalplacental histopathological findings. Methods: A prospective hospital-based cross-sectional survey of VDRL tests for two study groups HIV-positive tests and HIV-negative controls pregnant women at ante-natal care ANCdelivery. A convenient sampling method was used. Relevant maternalfetal historical data were extracted from their case notes, and placentas of reactive VDRL cases were histopathologically examined. Results: We surveyed 145 pregnant women 49 tests and 96 controls. The VDRL tests, for both groups, were not strongly associated with maternal age p-value  0.097, booking for ANC p-value  0.770, gravidity p-value  0.331, and HIVAIDS stage for tests only. Notably, one subject from the tests had a reactive VDRL test, and she was in HIVAIDS clinical stage 2, her baby had microcephaly fetal head circumference of 31 cm, low birth weight of 2.4 kilograms, and intermediate APGAR score. Histopathological examination of her placenta showed avascular villi, large hypercellular villi, and obliterative vasculopathy with an onion-skinning pattern in the placental disk. Conclusions: The obstetrical, fetal, and placental histopathological features of the reactive VDRL case were consistent with CS and syphilitic placentitis. Hence placental histopathological evaluation can play a critical role in the diagnosis of maternalcongenital syphilis.

 Objectives: Veneral Disease Research Laboratory VDRL test is an important screening tool for syphilis in pregnancy because of adverse pregnancy outcomes, particularly congenital syphilis CS and can be combined with the placental histopathological examination in the diagnosis of CS. Thus, we aimed to compare VDRL test results from HIV-positiveHIV-negative pregnant women with relevant historical data and perinatalplacental histopathological findings. Methods: A prospective hospital-based cross-sectional survey of VDRL tests for two study groups HIV-positive tests and HIV-negative controls pregnant women at ante-natal care ANCdelivery. A convenient sampling method was used. Relevant maternalfetal historical data were extracted from their case notes, and placentas of reactive VDRL cases were histopathologically examined. Results: We surveyed 145 pregnant women 49 tests and 96 controls. The VDRL tests, for both groups, were not strongly associated with maternal age p-value  0.097, booking for ANC p-value  0.770, gravidity p-value  0.331, and HIVAIDS stage for tests only. Notably, one subject from the tests had a reactive VDRL test, and she was in HIVAIDS clinical stage 2, her baby had microcephaly fetal head circumference of 31 cm, low birth weight of 2.4 kilograms, and intermediate APGAR score. Histopathological examination of her placenta showed avascular villi, large hypercellular villi, and obliterative vasculopathy with an onion-skinning pattern in the placental disk. Conclusions: The obstetrical, fetal, and placental histopathological features of the reactive VDRL case were consistent with CS and syphilitic placentitis. Hence placental histopathological evaluation can play a critical role in the diagnosis of maternalcongenital syphilis.

 Objectives: Veneral Disease Research Laboratory VDRL test is an important screening tool for syphilis in pregnancy because of adverse pregnancy outcomes, particularly congenital syphilis CS and can be combined with the placental histopathological examination in the diagnosis of CS. Thus, we aimed to compare VDRL test results from HIV-positiveHIV-negative pregnant women with relevant historical data and perinatalplacental histopathological findings. Methods: A prospective hospital-based cross-sectional survey of VDRL tests for two study groups HIV-positive tests and HIV-negative controls pregnant women at ante-natal care ANCdelivery. A convenient sampling method was used. Relevant maternalfetal historical data were extracted from their case notes, and placentas of reactive VDRL cases were histopathologically examined. Results: We surveyed 145 pregnant women 49 tests and 96 controls. The VDRL tests, for both groups, were not strongly associated with maternal age p-value  0.097, booking for ANC p-value  0.770, gravidity p-value  0.331, and HIVAIDS stage for tests only. Notably, one subject from the tests had a reactive VDRL test, and she was in HIVAIDS clinical stage 2, her baby had microcephaly fetal head circumference of 31 cm, low birth weight of 2.4 kilograms, and intermediate APGAR score. Histopathological examination of her placenta showed avascular villi, large hypercellular villi, and obliterative vasculopathy with an onion-skinning pattern in the placental disk. Conclusions: The obstetrical, fetal, and placental histopathological features of the reactive VDRL case were consistent with CS and syphilitic placentitis. Hence placental histopathological evaluation can play a critical role in the diagnosis of maternalcongenital syphilis.

 Objectives: Veneral Disease Research Laboratory VDRL test is an important screening tool for syphilis in pregnancy because of adverse pregnancy outcomes, particularly congenital syphilis CS and can be combined with the placental histopathological examination in the diagnosis of CS. Thus, we aimed to compare VDRL test results from HIV-positiveHIV-negative pregnant women with relevant historical data and perinatalplacental histopathological findings. Methods: A prospective hospital-based cross-sectional survey of VDRL tests for two study groups HIV-positive tests and HIV-negative controls pregnant women at ante-natal care ANCdelivery. A convenient sampling method was used. Relevant maternalfetal historical data were extracted from their case notes, and placentas of reactive VDRL cases were histopathologically examined. Results: We surveyed 145 pregnant women 49 tests and 96 controls. The VDRL tests, for both groups, were not strongly associated with maternal age p-value  0.097, booking for ANC p-value  0.770, gravidity p-value  0.331, and HIVAIDS stage for tests only. Notably, one subject from the tests had a reactive VDRL test, and she was in HIVAIDS clinical stage 2, her baby had microcephaly fetal head circumference of 31 cm, low birth weight of 2.4 kilograms, and intermediate APGAR score. Histopathological examination of her placenta showed avascular villi, large hypercellular villi, and obliterative vasculopathy with an onion-skinning pattern in the placental disk. Conclusions: The obstetrical, fetal, and placental histopathological features of the reactive VDRL case were consistent with CS and syphilitic placentitis. Hence placental histopathological evaluation can play a critical role in the diagnosis of maternalcongenital syphilis.

Makale detayları

A syphilis screening survey on HIV-positive and HIV-negative pregnant women, with placental histopathological evaluation of reactive cases, in a hospital in Uyo, Southern Nigeria

Yazarlar:

Uchechukwu Brian Eziagu

Yayıncı:

Dicle University

Ana Başlıklar:

Sağlık Kurumları Yönetimi

Dergi:

Dicle Tıp Dergisi Vol.50 Issue 1, pp.1-13

Belge Tipi:

Makale

Yayın Tarihi:

3/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001285391

pISSN:

1300-2945

VDRL test

HIV-positive

pregnant women

Syphilis

Placenta

Histopathology

Sayı

Makale detayları

A syphilis screening survey on HIV-positive and HIV-negative pregnant women, with placental histopathological evaluation of reactive cases, in a hospital in Uyo, Southern Nigeria

Yazarlar: Uchechukwu Brian Eziagu

Yayıncı: Dicle University

Ana Başlıklar: Sağlık Kurumları Yönetimi

Dergi: Dicle Tıp Dergisi Vol.50 Issue 1, pp.1-13

Belge Tipi: Makale

Yayın Tarihi: 3/2023

Belge Dili: İngilizce

Document ID (Org No.): 2001285391

pISSN: 1300-2945

VDRL test

HIV-positive

pregnant women

Syphilis

Placenta

Histopathology

Sayı

Yazarlar:

Uchechukwu Brian Eziagu

Yayıncı:

Dicle University

Ana Başlıklar:

Sağlık Kurumları Yönetimi

Dergi:

Dicle Tıp Dergisi Vol.50 Issue 1, pp.1-13

Belge Tipi:

Makale

Yayın Tarihi:

3/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001285391

pISSN:

1300-2945