Evaluation of the efficacy of maternal hemogram parameters in predicting meconium presence at birth in healthy pregnancies

Sebati Sinan Ürkmez; Özge Deniz Ünyeli; Yeşim Civil; Semra Eroglu; Sakine Merve Aydın; Canan Soyer Çalışkan; Zehra Yılmaz; Ceren Mert Soruklu; Samettin Çelik

Makale detayları

Evaluation of the efficacy of maternal hemogram parameters in predicting meconium presence at birth in healthy pregnancies

Yazarlar:

Sebati Sinan Ürkmez | Özge Deniz Ünyeli | Yeşim Civil | Semra Eroglu | Sakine Merve Aydın | Canan Soyer Çalışkan | Zehra Yılmaz | Ceren Mert Soruklu | Samettin Çelik

Yayıncı:

Ondokuz Mayıs University

Ana Başlıklar:

Clinical Chemistry | Medical Biochemistry and Metabolomics (Other) | Obstetrics and Gynaecology

Dergi:

Deneysel ve Klinik Tıp Dergisi Vol.41 Issue 3, pp.569-576

Belge Tipi:

Makale

Yayın Tarihi:

9/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001325926

pISSN:

1309-4483

Anahtar kelimeler:

Özet:

 The presence of meconium-stained amniotic fluid MSAF is a critical indicator of fetal distress, associated with increased neonatal morbidity and mortality. The aim of this study was to evaluate the potential of maternal blood parameters to predict the presence of meconium-stained amniotic fluid MSAF in term pregnancies. Data were retrospectively analyzed from healthy pregnant women who presented to Samsun Education and Research Hospital between 2014 and 2023 and delivered either by normal spontaneous delivery or cesarean section. The study included healthy pregnant women aged 18 and over who gave birth between 37 and 42 weeks of gestation. The non-invasive laboratory parameters investigated were neutrophil-to-lymphocyte ratio NLR, monocyte-to-lymphocyte ratio MLR, systemic immune-inflammation index SIRI, aggregate index of systemic inflammation AISI, and procalcitonin levels. Results showed that NLR, MLR, SIRI, AISI, and procalcitonin levels were significantly higher in the MSAF group. The ROC curve analysis demonstrated that SIRI cutoff: 3.55 had an AUC of 0.826 sensitivity: 89.2, specificity: 71.8. AISI cutoff: 1340.39 had an AUC of 0.749 sensitivity: 75.8, specificity: 70.9. NLR cutoff: 3.58 showed an AUC of 0.757 sensitivity: 87.5, specificity: 56.3. MLR cutoff: 0.55 presented an AUC of 0.822 sensitivity: 87.5, specificity: 74.8. However, SII demonstrated negligible and statistically non-significant diagnostic value. PLR and procalcitonin exhibited lower diagnostic efficacy. This study demonstrates that NLR, MLR, SIRI, AISI, and procalcitonin are effective non-invasive biomarkers for predicting the presence of MSAF in term pregnancies. These parameters can assist clinicians in anticipating fetal distress and the risk of meconium aspiration syndrome MAS, thereby improving perinatal outcomes through timely intervention.

 The presence of meconium-stained amniotic fluid MSAF is a critical indicator of fetal distress, associated with increased neonatal morbidity and mortality. The aim of this study was to evaluate the potential of maternal blood parameters to predict the presence of meconium-stained amniotic fluid MSAF in term pregnancies. Data were retrospectively analyzed from healthy pregnant women who presented to Samsun Education and Research Hospital between 2014 and 2023 and delivered either by normal spontaneous delivery or cesarean section. The study included healthy pregnant women aged 18 and over who gave birth between 37 and 42 weeks of gestation. The non-invasive laboratory parameters investigated were neutrophil-to-lymphocyte ratio NLR, monocyte-to-lymphocyte ratio MLR, systemic immune-inflammation index SIRI, aggregate index of systemic inflammation AISI, and procalcitonin levels. Results showed that NLR, MLR, SIRI, AISI, and procalcitonin levels were significantly higher in the MSAF group. The ROC curve analysis demonstrated that SIRI cutoff: 3.55 had an AUC of 0.826 sensitivity: 89.2, specificity: 71.8. AISI cutoff: 1340.39 had an AUC of 0.749 sensitivity: 75.8, specificity: 70.9. NLR cutoff: 3.58 showed an AUC of 0.757 sensitivity: 87.5, specificity: 56.3. MLR cutoff: 0.55 presented an AUC of 0.822 sensitivity: 87.5, specificity: 74.8. However, SII demonstrated negligible and statistically non-significant diagnostic value. PLR and procalcitonin exhibited lower diagnostic efficacy. This study demonstrates that NLR, MLR, SIRI, AISI, and procalcitonin are effective non-invasive biomarkers for predicting the presence of MSAF in term pregnancies. These parameters can assist clinicians in anticipating fetal distress and the risk of meconium aspiration syndrome MAS, thereby improving perinatal outcomes through timely intervention.

 The presence of meconium-stained amniotic fluid MSAF is a critical indicator of fetal distress, associated with increased neonatal morbidity and mortality. The aim of this study was to evaluate the potential of maternal blood parameters to predict the presence of meconium-stained amniotic fluid MSAF in term pregnancies. Data were retrospectively analyzed from healthy pregnant women who presented to Samsun Education and Research Hospital between 2014 and 2023 and delivered either by normal spontaneous delivery or cesarean section. The study included healthy pregnant women aged 18 and over who gave birth between 37 and 42 weeks of gestation. The non-invasive laboratory parameters investigated were neutrophil-to-lymphocyte ratio NLR, monocyte-to-lymphocyte ratio MLR, systemic immune-inflammation index SIRI, aggregate index of systemic inflammation AISI, and procalcitonin levels. Results showed that NLR, MLR, SIRI, AISI, and procalcitonin levels were significantly higher in the MSAF group. The ROC curve analysis demonstrated that SIRI cutoff: 3.55 had an AUC of 0.826 sensitivity: 89.2, specificity: 71.8. AISI cutoff: 1340.39 had an AUC of 0.749 sensitivity: 75.8, specificity: 70.9. NLR cutoff: 3.58 showed an AUC of 0.757 sensitivity: 87.5, specificity: 56.3. MLR cutoff: 0.55 presented an AUC of 0.822 sensitivity: 87.5, specificity: 74.8. However, SII demonstrated negligible and statistically non-significant diagnostic value. PLR and procalcitonin exhibited lower diagnostic efficacy. This study demonstrates that NLR, MLR, SIRI, AISI, and procalcitonin are effective non-invasive biomarkers for predicting the presence of MSAF in term pregnancies. These parameters can assist clinicians in anticipating fetal distress and the risk of meconium aspiration syndrome MAS, thereby improving perinatal outcomes through timely intervention.

 The presence of meconium-stained amniotic fluid MSAF is a critical indicator of fetal distress, associated with increased neonatal morbidity and mortality. The aim of this study was to evaluate the potential of maternal blood parameters to predict the presence of meconium-stained amniotic fluid MSAF in term pregnancies. Data were retrospectively analyzed from healthy pregnant women who presented to Samsun Education and Research Hospital between 2014 and 2023 and delivered either by normal spontaneous delivery or cesarean section. The study included healthy pregnant women aged 18 and over who gave birth between 37 and 42 weeks of gestation. The non-invasive laboratory parameters investigated were neutrophil-to-lymphocyte ratio NLR, monocyte-to-lymphocyte ratio MLR, systemic immune-inflammation index SIRI, aggregate index of systemic inflammation AISI, and procalcitonin levels. Results showed that NLR, MLR, SIRI, AISI, and procalcitonin levels were significantly higher in the MSAF group. The ROC curve analysis demonstrated that SIRI cutoff: 3.55 had an AUC of 0.826 sensitivity: 89.2, specificity: 71.8. AISI cutoff: 1340.39 had an AUC of 0.749 sensitivity: 75.8, specificity: 70.9. NLR cutoff: 3.58 showed an AUC of 0.757 sensitivity: 87.5, specificity: 56.3. MLR cutoff: 0.55 presented an AUC of 0.822 sensitivity: 87.5, specificity: 74.8. However, SII demonstrated negligible and statistically non-significant diagnostic value. PLR and procalcitonin exhibited lower diagnostic efficacy. This study demonstrates that NLR, MLR, SIRI, AISI, and procalcitonin are effective non-invasive biomarkers for predicting the presence of MSAF in term pregnancies. These parameters can assist clinicians in anticipating fetal distress and the risk of meconium aspiration syndrome MAS, thereby improving perinatal outcomes through timely intervention.

Makale detayları

Evaluation of the efficacy of maternal hemogram parameters in predicting meconium presence at birth in healthy pregnancies

Yazarlar:

Sebati Sinan Ürkmez | Özge Deniz Ünyeli | Yeşim Civil | Semra Eroglu | Sakine Merve Aydın | Canan Soyer Çalışkan | Zehra Yılmaz | Ceren Mert Soruklu | Samettin Çelik

Yayıncı:

Ondokuz Mayıs University

Ana Başlıklar:

Clinical Chemistry | Medical Biochemistry and Metabolomics (Other) | Obstetrics and Gynaecology

Dergi:

Deneysel ve Klinik Tıp Dergisi Vol.41 Issue 3, pp.569-576

Belge Tipi:

Makale

Yayın Tarihi:

9/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001325926

pISSN:

1309-4483

meconium

amniotic fluid

inflammation mediators

biomarkers

Sayı

Makale detayları

Evaluation of the efficacy of maternal hemogram parameters in predicting meconium presence at birth in healthy pregnancies

Yazarlar: Sebati Sinan Ürkmez | Özge Deniz Ünyeli | Yeşim Civil | Semra Eroglu | Sakine Merve Aydın | Canan Soyer Çalışkan | Zehra Yılmaz | Ceren Mert Soruklu | Samettin Çelik

Yayıncı: Ondokuz Mayıs University

Ana Başlıklar: Clinical Chemistry | Medical Biochemistry and Metabolomics (Other) | Obstetrics and Gynaecology

Dergi: Deneysel ve Klinik Tıp Dergisi Vol.41 Issue 3, pp.569-576

Belge Tipi: Makale

Yayın Tarihi: 9/2024

Belge Dili: İngilizce

Document ID (Org No.): 2001325926

pISSN: 1309-4483

meconium

amniotic fluid

inflammation mediators

biomarkers

Sayı

Yazarlar:

Sebati Sinan Ürkmez | Özge Deniz Ünyeli | Yeşim Civil | Semra Eroglu | Sakine Merve Aydın | Canan Soyer Çalışkan | Zehra Yılmaz | Ceren Mert Soruklu | Samettin Çelik

Yayıncı:

Ondokuz Mayıs University

Ana Başlıklar:

Clinical Chemistry | Medical Biochemistry and Metabolomics (Other) | Obstetrics and Gynaecology

Dergi:

Deneysel ve Klinik Tıp Dergisi Vol.41 Issue 3, pp.569-576

Belge Tipi:

Makale

Yayın Tarihi:

9/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001325926

pISSN:

1309-4483