Investigation of In Vitro antiproliferative activity properties of Spartium junceum L. (Spanish broom) against MDA-MB-231 and HepG2 cancer cell lines

Fatma Tuğçe Gürağaç Dereli; Senem Akkoç

Makale detayları

Investigation of In Vitro antiproliferative activity properties of Spartium junceum L. (Spanish broom) against MDA-MB-231 and HepG2 cancer cell lines

Yazarlar:

Fatma Tuğçe Gürağaç Dereli | Senem Akkoç

Yayıncı:

İzzet KARA

Ana Başlıklar:

Pharmacology and Pharmaceutical Sciences | Plant Biochemistry

Dergi:

International Journal of Secondary Metabolite Vol.10 Issue 3, pp.345-353

Belge Tipi:

Makale

Yayın Tarihi:

8/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001293609

pISSN:

2148-6905

Anahtar kelimeler:

Özet:

 Cancer is among the top global public health burdens leading to millions of deaths each year. The study aims to investigate the antiproliferative effect of Spartium junceum L. flowers on different cancer cell lines. The ethanolic extract of the flowers was prepared in the present study. Phytochemical analysis of the plant extract revealed the presence of several phenolic compounds such as cinnamic acid and its derivatives chlorogenic, p-coumaric, ferulic acids, protocatechuic acid, epicatechin and luteolin. This extract was tested against human breast MDA-MB-231 and liver HepG2 cancer cell lines to find out its antiproliferative activity. It was determined that the extract was effective against both cell lines with IC50 values of 2.37  0.47 and 0.98  0.01 µLmL for MDA-MB-231 and HepG2, respectively. Particularly, the extract was found to be more effective in the liver cancer cell line than the breast cancer cell line. All these obtained findings led us to believe that this medicinal plant could be a promising antiproliferative agent candidate for the treatment of human liver and breast cancers.

 Cancer is among the top global public health burdens leading to millions of deaths each year. The study aims to investigate the antiproliferative effect of Spartium junceum L. flowers on different cancer cell lines. The ethanolic extract of the flowers was prepared in the present study. Phytochemical analysis of the plant extract revealed the presence of several phenolic compounds such as cinnamic acid and its derivatives chlorogenic, p-coumaric, ferulic acids, protocatechuic acid, epicatechin and luteolin. This extract was tested against human breast MDA-MB-231 and liver HepG2 cancer cell lines to find out its antiproliferative activity. It was determined that the extract was effective against both cell lines with IC50 values of 2.37  0.47 and 0.98  0.01 µLmL for MDA-MB-231 and HepG2, respectively. Particularly, the extract was found to be more effective in the liver cancer cell line than the breast cancer cell line. All these obtained findings led us to believe that this medicinal plant could be a promising antiproliferative agent candidate for the treatment of human liver and breast cancers.

 Cancer is among the top global public health burdens leading to millions of deaths each year. The study aims to investigate the antiproliferative effect of Spartium junceum L. flowers on different cancer cell lines. The ethanolic extract of the flowers was prepared in the present study. Phytochemical analysis of the plant extract revealed the presence of several phenolic compounds such as cinnamic acid and its derivatives chlorogenic, p-coumaric, ferulic acids, protocatechuic acid, epicatechin and luteolin. This extract was tested against human breast MDA-MB-231 and liver HepG2 cancer cell lines to find out its antiproliferative activity. It was determined that the extract was effective against both cell lines with IC50 values of 2.37  0.47 and 0.98  0.01 µLmL for MDA-MB-231 and HepG2, respectively. Particularly, the extract was found to be more effective in the liver cancer cell line than the breast cancer cell line. All these obtained findings led us to believe that this medicinal plant could be a promising antiproliferative agent candidate for the treatment of human liver and breast cancers.

 Cancer is among the top global public health burdens leading to millions of deaths each year. The study aims to investigate the antiproliferative effect of Spartium junceum L. flowers on different cancer cell lines. The ethanolic extract of the flowers was prepared in the present study. Phytochemical analysis of the plant extract revealed the presence of several phenolic compounds such as cinnamic acid and its derivatives chlorogenic, p-coumaric, ferulic acids, protocatechuic acid, epicatechin and luteolin. This extract was tested against human breast MDA-MB-231 and liver HepG2 cancer cell lines to find out its antiproliferative activity. It was determined that the extract was effective against both cell lines with IC50 values of 2.37  0.47 and 0.98  0.01 µLmL for MDA-MB-231 and HepG2, respectively. Particularly, the extract was found to be more effective in the liver cancer cell line than the breast cancer cell line. All these obtained findings led us to believe that this medicinal plant could be a promising antiproliferative agent candidate for the treatment of human liver and breast cancers.

Makale detayları

Investigation of In Vitro antiproliferative activity properties of Spartium junceum L. (Spanish broom) against MDA-MB-231 and HepG2 cancer cell lines

Yazarlar:

Fatma Tuğçe Gürağaç Dereli | Senem Akkoç

Yayıncı:

İzzet KARA

Ana Başlıklar:

Pharmacology and Pharmaceutical Sciences | Plant Biochemistry

Dergi:

International Journal of Secondary Metabolite Vol.10 Issue 3, pp.345-353

Belge Tipi:

Makale

Yayın Tarihi:

8/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001293609

pISSN:

2148-6905

Antiproliferative activity

Cancer

Phenolic compounds

Spartium junceumAntiproliferative activity

Cancer

Phenolic compounds

Spartium junceum

Sayı

Makale detayları

Yazarlar: Fatma Tuğçe Gürağaç Dereli | Senem Akkoç

Yayıncı: İzzet KARA

Ana Başlıklar: Pharmacology and Pharmaceutical Sciences | Plant Biochemistry

Dergi: International Journal of Secondary Metabolite Vol.10 Issue 3, pp.345-353

Belge Tipi: Makale

Yayın Tarihi: 8/2023

Belge Dili: İngilizce

Document ID (Org No.): 2001293609

pISSN: 2148-6905

Sayı

Yazarlar:

Fatma Tuğçe Gürağaç Dereli | Senem Akkoç

Yayıncı:

İzzet KARA

Ana Başlıklar:

Pharmacology and Pharmaceutical Sciences | Plant Biochemistry

Dergi:

International Journal of Secondary Metabolite Vol.10 Issue 3, pp.345-353

Belge Tipi:

Makale

Yayın Tarihi:

8/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001293609

pISSN:

2148-6905