Abnormal retinal microvasculature found in active rheumatoid arthritis:a different perspective of microvascular health

Hakan BABAOĞLU; Ata BAYTAROĞLU; Murat TORĞUTALP; Abdulsamet ERDEN; Sibel KADAYIFÇILAR; Umut KALYONCU

Makale detayları

Abnormal retinal microvasculature found in active rheumatoid arthritis:a different perspective of microvascular health

Yazarlar:

Hakan BABAOĞLU | Ata BAYTAROĞLU | Murat TORĞUTALP | Abdulsamet ERDEN | Sibel KADAYIFÇILAR | Umut KALYONCU

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2019 Vol.49 Issue 1, pp.20-26

Belge Tipi:

Makale

Yayın Tarihi:

1/2019

Belge Dili:

Türkçe

Document ID (Org No.):

2000750255

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Özet:

 

We aimed to assess the association between retinal vascular caliber (RVC) scores and disease activity in rheumatoid arthritis (RA) patients.Materials and methods: Forty-seven RA patients, 32 systemic lupus erythematosus (SLE) patients, and 45 healthy people were enrolled. RA and SLE patients were subdivided into groups according to C-reactive protein (CRP) levels. RA patients were also grouped according to Disease Activity Score-28 (DAS-28). Fundus photography was performed for all patients. RVC was summarized as the central retinal artery and vein equivalents (CRAE and CRVE).Results: Mean CRVE for RA patients was 213.3 ± 17.8 µm compared with 209.2 ± 14.1 µm for SLE and 217.5 ± 26.2 µm for the control group (P = 0.17). RVC scores did not differ between the CRP-high and CRP-low groups. As the RA disease activity increased, the widening of CRVE became more prominent and statistically significant. When the DAS-28 > 5.1 (CRVE, 220.4 (211.8-246.5) µm) group and DAS-28 - 3.2 (CRVE, 214.4 (172.4-242.3) µm) group were compared, statistical significance was more pronounced (P = 0.03) than when comparing the DAS-28 > 3.2 and DAS-28 - 3.2 groups (P = 0.05). Conclusion: CRVE, which reflects systemic inflammation and possibly increased cardiovascular risk, was significantly increased in active RA patients. The association between retinal venular widening and disease activity, regardless of CRP, may be a sign that RA-related inflammation may have systemic vascular effects even with normal levels of CRP.

Makale detayları

Abnormal retinal microvasculature found in active rheumatoid arthritis:a different perspective of microvascular health

Yazarlar: Hakan BABAOĞLU | Ata BAYTAROĞLU | Murat TORĞUTALP | Abdulsamet ERDEN | Sibel KADAYIFÇILAR | Umut KALYONCU

Yayıncı: TUBITAK

Dergi: Turkish Journal of Medical Sciences 2019 Vol.49 Issue 1, pp.20-26

Belge Tipi: Makale

Yayın Tarihi: 1/2019

Belge Dili: Türkçe

Document ID (Org No.): 2000750255

Sıklık: İki Aylık

eISSN: 1303-6165

pISSN: 1300-0144

Sayı

Yazarlar:

Hakan BABAOĞLU | Ata BAYTAROĞLU | Murat TORĞUTALP | Abdulsamet ERDEN | Sibel KADAYIFÇILAR | Umut KALYONCU

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2019 Vol.49 Issue 1, pp.20-26

Belge Tipi:

Makale

Yayın Tarihi:

1/2019

Belge Dili:

Türkçe

Document ID (Org No.):

2000750255

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144