Histopathologic diagnosis of chronic viral hepatitis

Çiğdem Ataizi ÇELİKEL

doi:https://doi.org/10.5472/MMJsi.2901.05

Makale detayları

Histopathologic diagnosis of chronic viral hepatitis

Yazarlar:

Çiğdem Ataizi ÇELİKEL

Yayıncı:

Marmara University

Ana Başlıklar:

Hastalıklar

Dergi:

Marmara Medical Journal 2016 Vol.29 Issue 2, pp.18-28

Belge Tipi:

Makale

Yayın Tarihi:

7/2016

Belge Dili:

Türkçe

Document ID (Org No.):

2000544670

Sıklık:

Aylık

eISSN:

1309-9469

pISSN:

1019-1941

DOI:

https://doi.org/10.5472/MMJsi.2901.05

Özet:

 

Morphological evaluation of the liver continues to play a centralrole for the diagnosis, grading and staging of chronic viral hepatitis.The defining morphology is necroinflammation, that is hepatocyteinjury and inflammation. Hepatocyte injury is usually irreversible,and presents as apoptosis and/or necrosis. Mononuclear cellinfiltration of the portal tracts, that is usually accompanied byperiportal (interface) and lobular inflammation is typical. Continuednecroinflammatory activity at the limiting plate destroyingperiportal parenchyma initiates fibrogenesis leading to cirrhosis.Fibrosis can be reversible with fragmentation of scar tissue,resolving vascular derangements and parenchymal regeneration.Grading is a measure of the intensity of necroinflammatory activityand staging is a measure of fibrosis and architectural alteration.Besides staging, Laennec scoring system, subdividing cirrhosisthat is based on histologic parameters of fibrous septa width andnumber, has been advised to be used in reporting chronic viralhepatitis.Keywords: Viral hepatitis, Grading, Staging, Biopsy.

 

Morphological evaluation of the liver continues to play a centralrole for the diagnosis, grading and staging of chronic viral hepatitis.The defining morphology is necroinflammation, that is hepatocyteinjury and inflammation. Hepatocyte injury is usually irreversible,and presents as apoptosis and/or necrosis. Mononuclear cellinfiltration of the portal tracts, that is usually accompanied byperiportal (interface) and lobular inflammation is typical. Continuednecroinflammatory activity at the limiting plate destroyingperiportal parenchyma initiates fibrogenesis leading to cirrhosis.Fibrosis can be reversible with fragmentation of scar tissue,resolving vascular derangements and parenchymal regeneration.Grading is a measure of the intensity of necroinflammatory activityand staging is a measure of fibrosis and architectural alteration.Besides staging, Laennec scoring system, subdividing cirrhosisthat is based on histologic parameters of fibrous septa width andnumber, has been advised to be used in reporting chronic viralhepatitis.Keywords: Viral hepatitis, Grading, Staging, Biopsy.

Makale detayları

Histopathologic diagnosis of chronic viral hepatitis

Yazarlar: Çiğdem Ataizi ÇELİKEL

Yayıncı: Marmara University

Ana Başlıklar: Hastalıklar

Dergi: Marmara Medical Journal 2016 Vol.29 Issue 2, pp.18-28

Belge Tipi: Makale

Yayın Tarihi: 7/2016

Belge Dili: Türkçe

Document ID (Org No.): 2000544670

Sıklık: Aylık

eISSN: 1309-9469

pISSN: 1019-1941

DOI: https://doi.org/10.5472/MMJsi.2901.05

Sayı

Yazarlar:

Çiğdem Ataizi ÇELİKEL

Yayıncı:

Marmara University

Ana Başlıklar:

Hastalıklar

Dergi:

Marmara Medical Journal 2016 Vol.29 Issue 2, pp.18-28

Belge Tipi:

Makale

Yayın Tarihi:

7/2016

Belge Dili:

Türkçe

Document ID (Org No.):

2000544670

Sıklık:

Aylık

eISSN:

1309-9469

pISSN:

1019-1941

DOI:

https://doi.org/10.5472/MMJsi.2901.05