CRP/Albumin Ratio (CAR), Systemic Inflammation Index (SII), and Aggregate Index of Systemic Inflammation (AISI): Novel Prognostic Biomarkers in Patients Diagnosed with Influenza B

Ayshan Mammadova

Makale detayları

CRP/Albumin Ratio (CAR), Systemic Inflammation Index (SII), and Aggregate Index of Systemic Inflammation (AISI): Novel Prognostic Biomarkers in Patients Diagnosed with Influenza B

Yazarlar:

Ayshan Mammadova

Yayıncı:

Kirsehir Ahi Evran University

Ana Başlıklar:

Göğüs Hastalıkları

Dergi:

Ahi Evran Tıp Dergisi Vol.9 Issue 2, pp.153-159

Belge Tipi:

Makale

Yayın Tarihi:

8/2025

Belge Dili:

Türkçe

Document ID (Org No.):

2001345468

pISSN:

2619-9203

Anahtar kelimeler:

Özet:

 Purpose: Influenza can lead to various complications if not diagnosed and treated promptly. This study aimed to investigate the predictive value of the C-reactive proteinAlbumin Ratio CAR, Systemic Inflammation Index SII, and Aggregate Index of Systemic Inflammation AISI, which are derived from routine blood parameters, for influenza infection in adults. Materials and Methods: This retrospective, single-center study included 127 patients diagnosed and treated for influenza B. The control group consisted of 120 healthy individuals. Rapid antigen kits were used for the diagnosis of influenza B. Results: The median CAR, SII, and AISI values of the patients included in the study were 8.27 2.1223.63, 2154.45 640.248090, and 1085.14 300.914773.10, respectively. CAR, SII, and AISI values were significantly higher in hospitalized patients compared to those treated as outpatients p0.045, p0.001, p0.001. A positive correlation was found between hospitalization and CAR p0.001, r0.799, SII p0.001, r0.827, and AISI p0.001, r0.936. These indices were significantly higher in patients diagnosed with influenza B compared to the control group p0.001 for all. Cut-off values for CAR, SII, and AISI in diagnosing influenza B were determined by ROC analysis. The threshold values were 2.02 for CAR sensitivity 100, specificity 100, p0.001, 633.2 for SII AUC1.00, sensitivity 100, specificity 100, p0.001, and 397.56 for AISI AUC0.988, sensitivity 93.3, specificity 92.9, p0.001. Conclusion: Our study demonstrates that CAR, SII, and AISI, as non-invasive, low-cost, simple, and reproducible indices, have significant prognostic value in identifying, managing, and determining the hospitalization processes of adult patients with influenza B.

 Purpose: Influenza can lead to various complications if not diagnosed and treated promptly. This study aimed to investigate the predictive value of the C-reactive proteinAlbumin Ratio CAR, Systemic Inflammation Index SII, and Aggregate Index of Systemic Inflammation AISI, which are derived from routine blood parameters, for influenza infection in adults. Materials and Methods: This retrospective, single-center study included 127 patients diagnosed and treated for influenza B. The control group consisted of 120 healthy individuals. Rapid antigen kits were used for the diagnosis of influenza B. Results: The median CAR, SII, and AISI values of the patients included in the study were 8.27 2.1223.63, 2154.45 640.248090, and 1085.14 300.914773.10, respectively. CAR, SII, and AISI values were significantly higher in hospitalized patients compared to those treated as outpatients p0.045, p0.001, p0.001. A positive correlation was found between hospitalization and CAR p0.001, r0.799, SII p0.001, r0.827, and AISI p0.001, r0.936. These indices were significantly higher in patients diagnosed with influenza B compared to the control group p0.001 for all. Cut-off values for CAR, SII, and AISI in diagnosing influenza B were determined by ROC analysis. The threshold values were 2.02 for CAR sensitivity 100, specificity 100, p0.001, 633.2 for SII AUC1.00, sensitivity 100, specificity 100, p0.001, and 397.56 for AISI AUC0.988, sensitivity 93.3, specificity 92.9, p0.001. Conclusion: Our study demonstrates that CAR, SII, and AISI, as non-invasive, low-cost, simple, and reproducible indices, have significant prognostic value in identifying, managing, and determining the hospitalization processes of adult patients with influenza B.

 Purpose: Influenza can lead to various complications if not diagnosed and treated promptly. This study aimed to investigate the predictive value of the C-reactive proteinAlbumin Ratio CAR, Systemic Inflammation Index SII, and Aggregate Index of Systemic Inflammation AISI, which are derived from routine blood parameters, for influenza infection in adults. Materials and Methods: This retrospective, single-center study included 127 patients diagnosed and treated for influenza B. The control group consisted of 120 healthy individuals. Rapid antigen kits were used for the diagnosis of influenza B. Results: The median CAR, SII, and AISI values of the patients included in the study were 8.27 2.1223.63, 2154.45 640.248090, and 1085.14 300.914773.10, respectively. CAR, SII, and AISI values were significantly higher in hospitalized patients compared to those treated as outpatients p0.045, p0.001, p0.001. A positive correlation was found between hospitalization and CAR p0.001, r0.799, SII p0.001, r0.827, and AISI p0.001, r0.936. These indices were significantly higher in patients diagnosed with influenza B compared to the control group p0.001 for all. Cut-off values for CAR, SII, and AISI in diagnosing influenza B were determined by ROC analysis. The threshold values were 2.02 for CAR sensitivity 100, specificity 100, p0.001, 633.2 for SII AUC1.00, sensitivity 100, specificity 100, p0.001, and 397.56 for AISI AUC0.988, sensitivity 93.3, specificity 92.9, p0.001. Conclusion: Our study demonstrates that CAR, SII, and AISI, as non-invasive, low-cost, simple, and reproducible indices, have significant prognostic value in identifying, managing, and determining the hospitalization processes of adult patients with influenza B.

 Amaç: İnfluenza, zamanında tanı konulup tedavi edilmediğinde çeşitli komplikasyonlara yol açabilir. Bu çalışmada, yetişkinlerde rutin kan parametrelerinden türetilen CRPAlbümin Oranı CAR, Sistemik İnflamasyon İndeksi SII ve Sistemik İnflamasyonun Toplam İndeksinin AISI, influenza enfeksiyonu için öngörücü değerini araştırmak amaçlandı. Araçlar ve Yöntem: Retrospektif ve tek merkezli bu çalışmaya, influenza B tanısıyla tetkik ve tedavi edilen 127 hasta dahil edildi. Kontrol grubu ise 120 sağlıklı kişiden oluştu. İnfluenza B tanısında hızlı antijen kitleri kullanıldı. Bulgular: Çalışmaya dahil edilen hastaların CAR ortancası 8.27 2.12-23.63, SII ortancası 2154.45 640.24-8090 ve AISI ortancası 1085.14 300.91-4773.10 olarak belirlendi. Hastaneye yatışı yapılan hastalarda CAR, SII ve AISI değerleri, ayaktan tedavi alanlara göre anlamlı derecede daha yüksekti p0.045, p0.001, p0.001. Hastaneye yatış yapılan hastalar ile CAR p0.001, r0.799, SII p0.001, r0.827 ve AISI p0.001, r0.936 arasında pozitif korelasyon bulundu. Bu indeksler, influenza B tanısı olan hastalarda kontrol grubuna kıyasla anlamlı derecede daha yüksekti p0.001, p0.001, p0.001. İnfluenza B tanısında CAR, SII ve AISInin cut-off değerleri ROC analizi ile belirlendi. CAR için eşik değer 2.02 duyarlılık 100, özgüllük 100, p0.001, SII için 633.2 AUC1.00, duyarlılık 100, özgüllük 100, p0.001 ve AISI için 397.56 AUC0.988, duyarlılık 93.3, özgüllük 92.9, p0.001 tespit edildi. Sonuç: Çalışmamız, invaziv olmayan, düşük maliyetli, basit ve tekrarlanabilir indeksler olarak CAR, SII ve AISInin influenza Bli yetişkin hastaların tanımlanması, yönetimi ve hastaneye yatış süreçlerinde belirgin bir prognostik değere sahip olduğunu göstermektedir.

Makale detayları

CRP/Albumin Ratio (CAR), Systemic Inflammation Index (SII), and Aggregate Index of Systemic Inflammation (AISI): Novel Prognostic Biomarkers in Patients Diagnosed with Influenza B

Yazarlar:

Ayshan Mammadova

Yayıncı:

Kirsehir Ahi Evran University

Ana Başlıklar:

Göğüs Hastalıkları

Dergi:

Ahi Evran Tıp Dergisi Vol.9 Issue 2, pp.153-159

Belge Tipi:

Makale

Yayın Tarihi:

8/2025

Belge Dili:

Türkçe

Document ID (Org No.):

2001345468

pISSN:

2619-9203

complete blood count

nasopharyngeal swab

negative acute phase reactant

respiratory tract

viral ınfectionnazofarengeal sürüntü

negatif akut faz reaktanı

solunum yolu

tam kan sayımı

viral enfeksiyon

Sayı

Makale detayları

Yazarlar: Ayshan Mammadova

Yayıncı: Kirsehir Ahi Evran University

Ana Başlıklar: Göğüs Hastalıkları

Dergi: Ahi Evran Tıp Dergisi Vol.9 Issue 2, pp.153-159

Belge Tipi: Makale

Yayın Tarihi: 8/2025

Belge Dili: Türkçe

Document ID (Org No.): 2001345468

pISSN: 2619-9203

Sayı

Yazarlar:

Ayshan Mammadova

Yayıncı:

Kirsehir Ahi Evran University

Ana Başlıklar:

Göğüs Hastalıkları

Dergi:

Ahi Evran Tıp Dergisi Vol.9 Issue 2, pp.153-159

Belge Tipi:

Makale

Yayın Tarihi:

8/2025

Belge Dili:

Türkçe

Document ID (Org No.):

2001345468

pISSN:

2619-9203