The effect of IL-17 blockage on the neutrophil to lymphocyte ratio in patients with axial spondylarthritis: a comparative study with anti-TNF

Elem Yorulmaz

Makale detayları

The effect of IL-17 blockage on the neutrophil to lymphocyte ratio in patients with axial spondylarthritis: a comparative study with anti-TNF

Yazarlar:

Elem Yorulmaz

Yayıncı:

Prusa Medical Publishing

Ana Başlıklar:

Rheumatology and Arthritis

Dergi:

The European Research Journal Vol.9 Issue 1, pp.8-13

Belge Tipi:

Makale

Yayın Tarihi:

4/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001281616

pISSN:

2149-3189

Anahtar kelimeler:

Özet:

 Objectives: This study aims to evaluate the neutrophil to lymphocyte ratio NLR and platelet to lymphocyte ratio PLR in patients with axial spondyloarthritis receiving different biologic treatments. Methods: The study included 33 axial spondyloarthritis patients 20 males, 13 females receiving anti-TNF or secukinumab therapy. Patients age, disease duration, ongoing therapy duration, serum C-reactive protein CRP and erythrocyte sedimentation rate ESR, neutrophil, lymphocyte and platelet counts, Bath Ankylosing Spondylitis Disease Activity Index BASDAI scores, NLR, and PLR were recorded retrospectively. Results: The patients mean age was 44 years, and the diseases mean duration was 121.55 months. Fourteen 42.4 patients were receiving secukinumab, 57.6 of the patients were receiving anti-TNF agents. The malefemale ratio was 68 in the secukinumab group and 145 in the anti-TNF group. The ongoing therapy duration was 8  5.1 months for the secukinumab group and 27  27.6 months for the anti-TNF group. Only NLR was significantly higher in the secukinumab group, and there was no other statistical difference between groups. There was no correlation between NLR, PLR, and CRP, ESR, BASDAI. Conclusions: The results of our study show that only NLR is significantly higher in the secukinumab group compared to the anti-TNF group. Hence NLR may be a useful and sensitive parameter in terms of monitoring disease activity.

 Objectives: This study aims to evaluate the neutrophil to lymphocyte ratio NLR and platelet to lymphocyte ratio PLR in patients with axial spondyloarthritis receiving different biologic treatments. Methods: The study included 33 axial spondyloarthritis patients 20 males, 13 females receiving anti-TNF or secukinumab therapy. Patients age, disease duration, ongoing therapy duration, serum C-reactive protein CRP and erythrocyte sedimentation rate ESR, neutrophil, lymphocyte and platelet counts, Bath Ankylosing Spondylitis Disease Activity Index BASDAI scores, NLR, and PLR were recorded retrospectively. Results: The patients mean age was 44 years, and the diseases mean duration was 121.55 months. Fourteen 42.4 patients were receiving secukinumab, 57.6 of the patients were receiving anti-TNF agents. The malefemale ratio was 68 in the secukinumab group and 145 in the anti-TNF group. The ongoing therapy duration was 8  5.1 months for the secukinumab group and 27  27.6 months for the anti-TNF group. Only NLR was significantly higher in the secukinumab group, and there was no other statistical difference between groups. There was no correlation between NLR, PLR, and CRP, ESR, BASDAI. Conclusions: The results of our study show that only NLR is significantly higher in the secukinumab group compared to the anti-TNF group. Hence NLR may be a useful and sensitive parameter in terms of monitoring disease activity.

 Objectives: This study aims to evaluate the neutrophil to lymphocyte ratio NLR and platelet to lymphocyte ratio PLR in patients with axial spondyloarthritis receiving different biologic treatments. Methods: The study included 33 axial spondyloarthritis patients 20 males, 13 females receiving anti-TNF or secukinumab therapy. Patients age, disease duration, ongoing therapy duration, serum C-reactive protein CRP and erythrocyte sedimentation rate ESR, neutrophil, lymphocyte and platelet counts, Bath Ankylosing Spondylitis Disease Activity Index BASDAI scores, NLR, and PLR were recorded retrospectively. Results: The patients mean age was 44 years, and the diseases mean duration was 121.55 months. Fourteen 42.4 patients were receiving secukinumab, 57.6 of the patients were receiving anti-TNF agents. The malefemale ratio was 68 in the secukinumab group and 145 in the anti-TNF group. The ongoing therapy duration was 8  5.1 months for the secukinumab group and 27  27.6 months for the anti-TNF group. Only NLR was significantly higher in the secukinumab group, and there was no other statistical difference between groups. There was no correlation between NLR, PLR, and CRP, ESR, BASDAI. Conclusions: The results of our study show that only NLR is significantly higher in the secukinumab group compared to the anti-TNF group. Hence NLR may be a useful and sensitive parameter in terms of monitoring disease activity.

 Objectives: This study aims to evaluate the neutrophil to lymphocyte ratio NLR and platelet to lymphocyte ratio PLR in patients with axial spondyloarthritis receiving different biologic treatments. Methods: The study included 33 axial spondyloarthritis patients 20 males, 13 females receiving anti-TNF or secukinumab therapy. Patients age, disease duration, ongoing therapy duration, serum C-reactive protein CRP and erythrocyte sedimentation rate ESR, neutrophil, lymphocyte and platelet counts, Bath Ankylosing Spondylitis Disease Activity Index BASDAI scores, NLR, and PLR were recorded retrospectively. Results: The patients mean age was 44 years, and the diseases mean duration was 121.55 months. Fourteen 42.4 patients were receiving secukinumab, 57.6 of the patients were receiving anti-TNF agents. The malefemale ratio was 68 in the secukinumab group and 145 in the anti-TNF group. The ongoing therapy duration was 8  5.1 months for the secukinumab group and 27  27.6 months for the anti-TNF group. Only NLR was significantly higher in the secukinumab group, and there was no other statistical difference between groups. There was no correlation between NLR, PLR, and CRP, ESR, BASDAI. Conclusions: The results of our study show that only NLR is significantly higher in the secukinumab group compared to the anti-TNF group. Hence NLR may be a useful and sensitive parameter in terms of monitoring disease activity.

Makale detayları

The effect of IL-17 blockage on the neutrophil to lymphocyte ratio in patients with axial spondylarthritis: a comparative study with anti-TNF

Yazarlar:

Elem Yorulmaz

Yayıncı:

Prusa Medical Publishing

Ana Başlıklar:

Rheumatology and Arthritis

Dergi:

The European Research Journal Vol.9 Issue 1, pp.8-13

Belge Tipi:

Makale

Yayın Tarihi:

4/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001281616

pISSN:

2149-3189

Axial spondyloarthritis

neutrophil to lymphocyte ratio

platelet to lymphocyte ratio

secukinumab

Sayı

Makale detayları

The effect of IL-17 blockage on the neutrophil to lymphocyte ratio in patients with axial spondylarthritis: a comparative study with anti-TNF

Yazarlar: Elem Yorulmaz

Yayıncı: Prusa Medical Publishing

Ana Başlıklar: Rheumatology and Arthritis

Dergi: The European Research Journal Vol.9 Issue 1, pp.8-13

Belge Tipi: Makale

Yayın Tarihi: 4/2023

Belge Dili: İngilizce

Document ID (Org No.): 2001281616

pISSN: 2149-3189

Axial spondyloarthritis

neutrophil to lymphocyte ratio

platelet to lymphocyte ratio

secukinumab

Sayı

Yazarlar:

Elem Yorulmaz

Yayıncı:

Prusa Medical Publishing

Ana Başlıklar:

Rheumatology and Arthritis

Dergi:

The European Research Journal Vol.9 Issue 1, pp.8-13

Belge Tipi:

Makale

Yayın Tarihi:

4/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001281616

pISSN:

2149-3189