Synthesis and antimicrobial activity of novel 2-(pyridin-2-yl)thieno[2,3-d]pyrimidin-4 (3H)-ones

Nitin G. HASWANI; Sanjaykumar B. BARI

Makale detayları

Synthesis and antimicrobial activity of novel 2-(pyridin-2-yl)thieno[2,3-d]pyrimidin-4 (3H)-ones

Yazarlar:

Nitin G. HASWANI | Sanjaykumar B. BARI

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Chemistry 2011 Vol.35 Issue 6, pp.915-924

Belge Tipi:

Makale

Yayın Tarihi:

5/2011

Belge Dili:

Türkçe

Document ID (Org No.):

2000727737

Sıklık:

İki Aylık

eISSN:

1303-6130

pISSN:

1300-0527

Özet:

 

In the present study, some new 2-(pyridin-2-yl)thieno[2,3-d]  pyrimidin-4(3H)-ones derivatives (IIa-o) were synthesized.  The target  compounds (IIa-o) were synthesized through the acid catalyzed  condensation of 2-cyano, 3-cyano, and 4-cyano-pyridines with various  2-amino-3-carbethoxythiophenes (Ia-e).  All thiophene derivatives were  synthesized by Gewald reaction.  The structures of the newly  synthesized compounds were confirmed by UV-Visible, FT-IR, 1H-NMR,  and mass spectral studies.  All synthesized compounds were evaluated  for their antimicrobial activity against various gram-positive and  gram-negative bacterial and fungal strains.  Amongst the synthesized  compounds IIa, IIb, IId, IIe, and IIm were found to be active.

 

In the present study, some new 2-(pyridin-2-yl)thieno[2,3-d]  pyrimidin-4(3H)-ones derivatives (IIa-o) were synthesized.  The target  compounds (IIa-o) were synthesized through the acid catalyzed  condensation of 2-cyano, 3-cyano, and 4-cyano-pyridines with various  2-amino-3-carbethoxythiophenes (Ia-e).  All thiophene derivatives were  synthesized by Gewald reaction.  The structures of the newly  synthesized compounds were confirmed by UV-Visible, FT-IR, 1H-NMR,  and mass spectral studies.  All synthesized compounds were evaluated  for their antimicrobial activity against various gram-positive and  gram-negative bacterial and fungal strains.  Amongst the synthesized  compounds IIa, IIb, IId, IIe, and IIm were found to be active.

Makale detayları

Synthesis and antimicrobial activity of novel 2-(pyridin-2-yl)thieno[2,3-d]pyrimidin-4 (3H)-ones

Yazarlar: Nitin G. HASWANI | Sanjaykumar B. BARI

Yayıncı: TUBITAK

Dergi: Turkish Journal of Chemistry 2011 Vol.35 Issue 6, pp.915-924

Belge Tipi: Makale

Yayın Tarihi: 5/2011

Belge Dili: Türkçe

Document ID (Org No.): 2000727737

Sıklık: İki Aylık

eISSN: 1303-6130

pISSN: 1300-0527

Sayı

Yazarlar:

Nitin G. HASWANI | Sanjaykumar B. BARI

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Chemistry 2011 Vol.35 Issue 6, pp.915-924

Belge Tipi:

Makale

Yayın Tarihi:

5/2011

Belge Dili:

Türkçe

Document ID (Org No.):

2000727737

Sıklık:

İki Aylık

eISSN:

1303-6130

pISSN:

1300-0527