Ginger (Zingiber officinale) prevents severe damage to the lungs due to hyperoxia and  inflammation

ATİLLA ÇİFCİ; CÜNEYT TAYMAN; HALİL İBRAHİM YAKUT; Halit HALİL; ESRA ÇAKIR; Ufuk ÇAKIR; SALİH AYDEMİR

Makale detayları

Ginger (Zingiber officinale) prevents severe damage to the lungs due to hyperoxia and inflammation

Yazarlar:

ATİLLA ÇİFCİ | CÜNEYT TAYMAN | HALİL İBRAHİM YAKUT | Halit HALİL | ESRA ÇAKIR | Ufuk ÇAKIR | SALİH AYDEMİR

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2018 Vol.48 Issue 4, pp.892-900

Belge Tipi:

Makale

Yayın Tarihi:

7/2018

Belge Dili:

Türkçe

Document ID (Org No.):

2000750678

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Özet:

 

Background/aim: Hyperoxia- and inflammation-induced lung injury is an important cause of the development of bronchopulmonary  dysplasia (BPD) in premature infants. We aimed to ascertain the beneficial effects of ginger (Zingiber officinale) on rat pups exposed to  hyperoxia and inflammation.  Materials and methods: Thirty-six newborn Wistar rats were randomly divided into 3 groups as the hyperoxia (95% O2) +  lipopolysaccharide (LPS) group, the hyperoxia + LPS + ginger-treated group, and the control/no treatment group (21% O2). Pups in the  hyperoxia + LPS + ginger group were administered oral ginger at a dose of 1000 mg/kg daily during the study period. Histopathologic,  immunochemical (SMA and lamellar body), and biochemical evaluations including total antioxidant status (TAS), total oxidant  status (TOS), malondialdehyde (MDA), myeloperoxidase (MPO), tumor necrosis factor-alpha (TNF-α), interleukin-1 beta (IL-1ß),  interleukin-6 (IL-6), and caspase-3 activities were performed.  Results: Better weight gain and survival rates were shown in the hyperoxia + LPS + ginger group (P < 0.05). In the histopathologic  and immunochemical evaluation, severity of lung damage was significantly reduced in the hyperoxia + LPS + ginger group, as well  as decreased apoptosis (ELISA for caspase-3) (P < 0.05). Tissue TAS levels were significantly protected, and TOS, MDA, and MPO  levels were significantly lower in the hyperoxia + LPS + ginger group (P < 0.05). Tissue TNF-α, IL-1ß, and IL-6 concentrations were  significantly decreased in the ginger-treated group (P < 0.05).  Conclusion: Ginger efficiently reduced the lung damage and protected the lungs from severe damage due to hyperoxia and inflammation.  Therefore, ginger may be an alternative option for the treatment of BPD.

Makale detayları

Ginger (Zingiber officinale) prevents severe damage to the lungs due to hyperoxia and inflammation

Yazarlar: ATİLLA ÇİFCİ | CÜNEYT TAYMAN | HALİL İBRAHİM YAKUT | Halit HALİL | ESRA ÇAKIR | Ufuk ÇAKIR | SALİH AYDEMİR

Yayıncı: TUBITAK

Dergi: Turkish Journal of Medical Sciences 2018 Vol.48 Issue 4, pp.892-900

Belge Tipi: Makale

Yayın Tarihi: 7/2018

Belge Dili: Türkçe

Document ID (Org No.): 2000750678

Sıklık: İki Aylık

eISSN: 1303-6165

pISSN: 1300-0144

Sayı

Yazarlar:

ATİLLA ÇİFCİ | CÜNEYT TAYMAN | HALİL İBRAHİM YAKUT | Halit HALİL | ESRA ÇAKIR | Ufuk ÇAKIR | SALİH AYDEMİR

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2018 Vol.48 Issue 4, pp.892-900

Belge Tipi:

Makale

Yayın Tarihi:

7/2018

Belge Dili:

Türkçe

Document ID (Org No.):

2000750678

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144