Action of Aspirin on Acetylcholine-Stimulated  Tear Secretion in Rats

Zerrin KAPICIOĞLU

Makale detayları

Action of Aspirin on Acetylcholine-Stimulated Tear Secretion in Rats

Yazarlar:

Zerrin KAPICIOĞLU

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 1999 Vol.29 Issue 6, pp.623-626

Belge Tipi:

Makale

Yayın Tarihi:

5/1999

Belge Dili:

Türkçe

Document ID (Org No.):

2000757780

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Anahtar kelimeler:

Özet:

 

In this study we investigated the effect of acetylsalicylic acid (ASA) on tear secretion in rats. The animals were   anesthetized intraperitoneally (ip) with urethane (1,2g/kg). The treatment was injected subcutaneously (s.c.). Tear samples were collected by folding a 5 mm section of a Schirmer strip over the lower lid margin to absorb tear fluid from the lower conjunctival sac for 5 min. Forty animals were divided into four groups (n=10). Group 1 (control) received 1ml of saline, group 2 received 60mg/kg of ASA, group 3 received 50mg/kg of Acetylcholine (Ach), and group 4 received   60mg/kg of ASA and 30 min later 50mg of Ach. While Ach alone significantly increased tear secretion, ASA reduced it when compared to saline (control) (p.

 

In this study we investigated the effect of acetylsalicylic acid (ASA) on tear secretion in rats. The animals were   anesthetized intraperitoneally (ip) with urethane (1,2g/kg). The treatment was injected subcutaneously (s.c.). Tear samples were collected by folding a 5 mm section of a Schirmer strip over the lower lid margin to absorb tear fluid from the lower conjunctival sac for 5 min. Forty animals were divided into four groups (n=10). Group 1 (control) received 1ml of saline, group 2 received 60mg/kg of ASA, group 3 received 50mg/kg of Acetylcholine (Ach), and group 4 received   60mg/kg of ASA and 30 min later 50mg of Ach. While Ach alone significantly increased tear secretion, ASA reduced it when compared to saline (control) (p.

Makale detayları

Action of Aspirin on Acetylcholine-Stimulated Tear Secretion in Rats

Yazarlar:

Zerrin KAPICIOĞLU

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 1999 Vol.29 Issue 6, pp.623-626

Belge Tipi:

Makale

Yayın Tarihi:

5/1999

Belge Dili:

Türkçe

Document ID (Org No.):

2000757780

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Aspirin

acetylsalicylic acid

acetylcholine

tear secretion

rat.

Sayı

Makale detayları

Action of Aspirin on Acetylcholine-Stimulated Tear Secretion in Rats

Yazarlar: Zerrin KAPICIOĞLU

Yayıncı: TUBITAK

Dergi: Turkish Journal of Medical Sciences 1999 Vol.29 Issue 6, pp.623-626

Belge Tipi: Makale

Yayın Tarihi: 5/1999

Belge Dili: Türkçe

Document ID (Org No.): 2000757780

Sıklık: İki Aylık

eISSN: 1303-6165

pISSN: 1300-0144

Aspirin

acetylsalicylic acid

acetylcholine

tear secretion

rat.

Sayı

Yazarlar:

Zerrin KAPICIOĞLU

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 1999 Vol.29 Issue 6, pp.623-626

Belge Tipi:

Makale

Yayın Tarihi:

5/1999

Belge Dili:

Türkçe

Document ID (Org No.):

2000757780

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144