Synthesis, characterization and biological activity studies on amide derivatives

Sevda TÜRK; Kadir TURAN; Seyhan ULUSOY; Sevgi KARAKUŞ; Gülgün BOŞGELMEZ-TINAZ

Makale detayları

Synthesis, characterization and biological activity studies on amide derivatives

Yazarlar:

Sevda TÜRK | Kadir TURAN | Seyhan ULUSOY | Sevgi KARAKUŞ | Gülgün BOŞGELMEZ-TINAZ

Yayıncı:

Istanbul University

Ana Başlıklar:

Farmakoloji ve terapötik

Dergi:

İstanbul Journal of Pharmacy 2018 Vol.48 Issue 3, pp.76-81

Belge Tipi:

Makale

Yayın Tarihi:

11/2018

Belge Dili:

İngilizce

Document ID (Org No.):

2000513051

Sıklık:

Aylık

eISSN:

2587-2087

Özet:

 


DOI : 10.26650/IstanbulJPharm.2018.18007


In this study, with intent to find out novel anti-biofilm and antiviral agents, a series of amide derivatives were synthesized and their structures were elucidated by FT-IR and 1H-NMR and 13C-NMR and MS methods. And also, their purity were proven by TLC, HPLC and elemental analyses. And finally, the synthesized compounds were examined for their biofilm formation and swarming motility inhibitory activities in P. aeruginosa PA01. These compounds were found to reduce biofilm formation by 8.7-25.6% and swarming motility by 18.3-33.8% in P. aeruginosa PA01 at a concentration of 200 μM. Besides, all of the compounds were evaluated for their antiviral activity against influenza A viruses. The plaque inhibition assays indicated that compound 6 (N-(4-{[5-(ethylamino)-1,3,4-thiadiazol-2-yl]methyl}phenyl)-4- fluorobenzamide) has considerable inhibitory effect on influenza A virus plaque formation.

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Makale detayları

Synthesis, characterization and biological activity studies on amide derivatives

Yazarlar: Sevda TÜRK | Kadir TURAN | Seyhan ULUSOY | Sevgi KARAKUŞ | Gülgün BOŞGELMEZ-TINAZ

Yayıncı: Istanbul University

Ana Başlıklar: Farmakoloji ve terapötik

Dergi: İstanbul Journal of Pharmacy 2018 Vol.48 Issue 3, pp.76-81

Belge Tipi: Makale

Yayın Tarihi: 11/2018

Belge Dili: İngilizce

Document ID (Org No.): 2000513051

Sıklık: Aylık

eISSN: 2587-2087

Sayı

Yazarlar:

Sevda TÜRK | Kadir TURAN | Seyhan ULUSOY | Sevgi KARAKUŞ | Gülgün BOŞGELMEZ-TINAZ

Yayıncı:

Istanbul University

Ana Başlıklar:

Farmakoloji ve terapötik

Dergi:

İstanbul Journal of Pharmacy 2018 Vol.48 Issue 3, pp.76-81

Belge Tipi:

Makale

Yayın Tarihi:

11/2018

Belge Dili:

İngilizce

Document ID (Org No.):

2000513051

Sıklık:

Aylık

eISSN:

2587-2087