Adverse Effects to Suckling Mice Following Indirect Exposure to a Pesticide Mixture and Ameliorative Effect of α-Tocopherol Coadministration

Sameeh MANSOUR; Mohamed ABDEL-MAGEED; Khaled MOHAMED; Marwa GAD; Laurence GAMET-PAYRASTRE

doi:https://doi.org/10.5152/jbachs.2017.227

Makale detayları

Adverse Effects to Suckling Mice Following Indirect Exposure to a Pesticide Mixture and Ameliorative Effect of α-Tocopherol Coadministration

Yazarlar:

Sameeh MANSOUR | Mohamed ABDEL-MAGEED | Khaled MOHAMED | Marwa GAD | Laurence GAMET-PAYRASTRE

Yayıncı:

Dokuz Eylul University

Dergi:

Journal of Basic and Clinical Health Sciences 2017 Vol.1 Issue 3, pp.71-78

Belge Tipi:

Makale

Yayın Tarihi:

8/2017

Belge Dili:

İngilizce

Document ID (Org No.):

2000493730

Sıklık:

Üç Yıllık

eISSN:

2564-7288

DOI:

https://doi.org/10.5152/jbachs.2017.227

Özet:

 

Purpose: The present study was conducted to evaluate the oxidative damage and biochemical and histopathological alterations in suckling mice whose mothers were exposed to a mixture of three pesticides  atrazine “A,” chlorpyrifos “C,” and endosulfan “E”; ACE  with and without vitamin E  α-tocopherol  supplementation.Methods: During gestation, the mouse dams were fed a diet free of chemicals. Just after parturition and up to offspring weaning  ca. 20 days , the mouse dams received one of the following diets:  a  a diet free of ACE,  b  a diet enriched with ACE  at Acceptable Daily Intake  ADI : 0.005, 0.01, and 0.006 mg/kg bw/day ,  c  a diet free of ACE+oral vitamin E  100 ul/mouse/day , or  d  a diet enriched with ACE+oral vitamin E. Drinking water was allowed ad libitum up to 42 days. After weaning, blood samples and organs were collected from pups and dams for analyses. Results: Compared with the control results of dams or their pups, the ACE mixture induced high elevation in AST, ALT, ALP, urea, and MDA and high decline in BuChE, SOD, and CAT. The suckling pups were more affected than the dams with respect to alterations in MDA and BuChE activities, whereas the opposite was observed with respect to SOD activities. Vitamin E supplementation alleviated the oxidative stress exerted by the tested mixture. Conclusion: The findings of this study explore extension of the adverse effects of the ACE mixture to mouse offspring and the powerful ameliorating effect of vitamin E supplementation.

Makale detayları

Adverse Effects to Suckling Mice Following Indirect Exposure to a Pesticide Mixture and Ameliorative Effect of α-Tocopherol Coadministration

Yazarlar: Sameeh MANSOUR | Mohamed ABDEL-MAGEED | Khaled MOHAMED | Marwa GAD | Laurence GAMET-PAYRASTRE

Yayıncı: Dokuz Eylul University

Dergi: Journal of Basic and Clinical Health Sciences 2017 Vol.1 Issue 3, pp.71-78

Belge Tipi: Makale

Yayın Tarihi: 8/2017

Belge Dili: İngilizce

Document ID (Org No.): 2000493730

Sıklık: Üç Yıllık

eISSN: 2564-7288

DOI: https://doi.org/10.5152/jbachs.2017.227

Sayı

Yazarlar:

Sameeh MANSOUR | Mohamed ABDEL-MAGEED | Khaled MOHAMED | Marwa GAD | Laurence GAMET-PAYRASTRE

Yayıncı:

Dokuz Eylul University

Dergi:

Journal of Basic and Clinical Health Sciences 2017 Vol.1 Issue 3, pp.71-78

Belge Tipi:

Makale

Yayın Tarihi:

8/2017

Belge Dili:

İngilizce

Document ID (Org No.):

2000493730

Sıklık:

Üç Yıllık

eISSN:

2564-7288

DOI:

https://doi.org/10.5152/jbachs.2017.227