Impaired vascular function induced by aging: Role of irisin and perivascular adipose tissue

Zarife Nigar Özdemir Kumral; Nurdan Bülbül Aycı; Özlem Tuğçe Çilingir Kaya; Hızır Kurtel

Makale detayları

Impaired vascular function induced by aging: Role of irisin and perivascular adipose tissue

Yazarlar:

Zarife Nigar Özdemir Kumral | Nurdan Bülbül Aycı | Özlem Tuğçe Çilingir Kaya | Hızır Kurtel

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmacology and Pharmaceutical Sciences (Other)

Dergi:

Journal of Research in Pharmacy Vol.27 Issue 2, pp.733-752

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001347837

pISSN:

2630-6344

Anahtar kelimeler:

Özet:

 The aim of the study is to explain the possible effects of exercise-induced novel peptide irisin on endothelial function accompanied by perivascular adipose tissue PVAT in aortas of both natural aging and D- galactose D-Gal aging mimetic rats. Female Sprague-Dawley rats were randomly divided into 6 groups n10per group: sedentary young group SY, exercised young group EY, sedentary aging group SA, exercised aging group EA, sedentary D-Gal 300 mgkgday, i.p., 9 weeks induced aging group SD-Gal, exercised D-Gal induced aging group ED-Gal. Cardiac and aortic samples were collected for biochemical and histopathological examinations. The aortas were taken for contractile response studies in the absence or presence of perivascular adipose tissue PVAT-. The levels of irisin in both plasma and PVAT were detected. Regardless of the models the vaso-relaxant effects of irisin were shown alone and age-related vascular dysfunction has also been recorded compared to the SY group these age- related impaired irisin responses were found to be improved by regular exercise. The plasma and PVAT irisin levels were decreased by aging and exercise reversed this decrement which is verified by the immune expression of irisin in aortic and PVAT tissues. Our results show the differences in vascular function and PVAT in aging and the contribution of PVAT to the response of irisin with exercise in two different aging models.

 The aim of the study is to explain the possible effects of exercise-induced novel peptide irisin on endothelial function accompanied by perivascular adipose tissue PVAT in aortas of both natural aging and D- galactose D-Gal aging mimetic rats. Female Sprague-Dawley rats were randomly divided into 6 groups n10per group: sedentary young group SY, exercised young group EY, sedentary aging group SA, exercised aging group EA, sedentary D-Gal 300 mgkgday, i.p., 9 weeks induced aging group SD-Gal, exercised D-Gal induced aging group ED-Gal. Cardiac and aortic samples were collected for biochemical and histopathological examinations. The aortas were taken for contractile response studies in the absence or presence of perivascular adipose tissue PVAT-. The levels of irisin in both plasma and PVAT were detected. Regardless of the models the vaso-relaxant effects of irisin were shown alone and age-related vascular dysfunction has also been recorded compared to the SY group these age- related impaired irisin responses were found to be improved by regular exercise. The plasma and PVAT irisin levels were decreased by aging and exercise reversed this decrement which is verified by the immune expression of irisin in aortic and PVAT tissues. Our results show the differences in vascular function and PVAT in aging and the contribution of PVAT to the response of irisin with exercise in two different aging models.

 The aim of the study is to explain the possible effects of exercise-induced novel peptide irisin on endothelial function accompanied by perivascular adipose tissue PVAT in aortas of both natural aging and D- galactose D-Gal aging mimetic rats. Female Sprague-Dawley rats were randomly divided into 6 groups n10per group: sedentary young group SY, exercised young group EY, sedentary aging group SA, exercised aging group EA, sedentary D-Gal 300 mgkgday, i.p., 9 weeks induced aging group SD-Gal, exercised D-Gal induced aging group ED-Gal. Cardiac and aortic samples were collected for biochemical and histopathological examinations. The aortas were taken for contractile response studies in the absence or presence of perivascular adipose tissue PVAT-. The levels of irisin in both plasma and PVAT were detected. Regardless of the models the vaso-relaxant effects of irisin were shown alone and age-related vascular dysfunction has also been recorded compared to the SY group these age- related impaired irisin responses were found to be improved by regular exercise. The plasma and PVAT irisin levels were decreased by aging and exercise reversed this decrement which is verified by the immune expression of irisin in aortic and PVAT tissues. Our results show the differences in vascular function and PVAT in aging and the contribution of PVAT to the response of irisin with exercise in two different aging models.

 The aim of the study is to explain the possible effects of exercise-induced novel peptide irisin on endothelial function accompanied by perivascular adipose tissue PVAT in aortas of both natural aging and D- galactose D-Gal aging mimetic rats. Female Sprague-Dawley rats were randomly divided into 6 groups n10per group: sedentary young group SY, exercised young group EY, sedentary aging group SA, exercised aging group EA, sedentary D-Gal 300 mgkgday, i.p., 9 weeks induced aging group SD-Gal, exercised D-Gal induced aging group ED-Gal. Cardiac and aortic samples were collected for biochemical and histopathological examinations. The aortas were taken for contractile response studies in the absence or presence of perivascular adipose tissue PVAT-. The levels of irisin in both plasma and PVAT were detected. Regardless of the models the vaso-relaxant effects of irisin were shown alone and age-related vascular dysfunction has also been recorded compared to the SY group these age- related impaired irisin responses were found to be improved by regular exercise. The plasma and PVAT irisin levels were decreased by aging and exercise reversed this decrement which is verified by the immune expression of irisin in aortic and PVAT tissues. Our results show the differences in vascular function and PVAT in aging and the contribution of PVAT to the response of irisin with exercise in two different aging models.

Makale detayları

Impaired vascular function induced by aging: Role of irisin and perivascular adipose tissue

Yazarlar: Zarife Nigar Özdemir Kumral | Nurdan Bülbül Aycı | Özlem Tuğçe Çilingir Kaya | Hızır Kurtel

Yayıncı: Marmara University

Ana Başlıklar: Pharmacology and Pharmaceutical Sciences (Other)

Dergi: Journal of Research in Pharmacy Vol.27 Issue 2, pp.733-752

Belge Tipi: Makale

Yayın Tarihi: 6/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001347837

pISSN: 2630-6344

exercise

aging

vascular dysfunction

irisin

PVAT

Sayı

Yazarlar:

Zarife Nigar Özdemir Kumral | Nurdan Bülbül Aycı | Özlem Tuğçe Çilingir Kaya | Hızır Kurtel

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmacology and Pharmaceutical Sciences (Other)

Dergi:

Journal of Research in Pharmacy Vol.27 Issue 2, pp.733-752

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001347837

pISSN:

2630-6344