The relationship between bone mineral density and hematological parameters in the geriatric age group

Erhan ÖNALAN; Yusuf GOKALP

doi:https://doi.org/10.22391/fppc.634197

Makale detayları

The relationship between bone mineral density and hematological parameters in the geriatric age group

Yazarlar:

Erhan ÖNALAN | Yusuf GOKALP

Ana Başlıklar:

Hastalıklar

Dergi:

Family Practice and Palliative Care 2020 Vol.5 Issue 1, pp.1-5

Belge Tipi:

Makale

Yayın Tarihi:

1/2020

Belge Dili:

İngilizce

Document ID (Org No.):

2000429358

DOI:

https://doi.org/10.22391/fppc.634197

Özet:

 


Introduction: As populations gradually become older, osteoporosis manifests itself as
an important public health problem. Studies have shown that inflammation plays
a critical role in the pathogenesis of osteoporosis. NLR (neutrophil to
lymphocyte ratio) and PLR (platelet to lymphocyte ratio) are simple,
non-invasive, and inexpensive markers of inflammation in malignancies and
inflammatory diseases. This study aims to compare osteopenic, osteoporotic, and
control subjects, who do not have other known diseases or a history of
medication use, in terms of their NLR and PLR levels and evaluate the
relationship between NLR, PLR levels and BMD.


Methods: This cross-sectional study included a total of 308 patients aged 65 or
above. Total bone mineral density (BMD) was measured using dual energy X-ray
absorptiometry (DEXA). Complete blood count (CBC), biomarkers of inflammation
(C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), glucose/lipid
metabolism, and thyroid function test results were recorded.


Results: The osteoporosis group demonstrated higher NLR levels compared to the
osteopenic and control groups (respectively 3.58 ± 4.22,
2.64 ± 1.99, and 2.36 ± 1.39), and this
relationship between the groups was found to be statistically significant
(p=0.025). Our data revealed higher sedimentation values for the osteoporosis
group than for the osteopenic and healthy control groups with statistical
significance (p=0.011).

Conclusions: The fact that individuals with geriatric osteoporosis demonstrate
elevated NLR levels and that this elevation is also seen in sedimentation
suggests that inflammation plays an important role in bone remodelling.

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Makale detayları

The relationship between bone mineral density and hematological parameters in the geriatric age group

Yazarlar: Erhan ÖNALAN | Yusuf GOKALP

Ana Başlıklar: Hastalıklar

Dergi: Family Practice and Palliative Care 2020 Vol.5 Issue 1, pp.1-5

Belge Tipi: Makale

Yayın Tarihi: 1/2020

Belge Dili: İngilizce

Document ID (Org No.): 2000429358

DOI: https://doi.org/10.22391/fppc.634197

Sayı

Yazarlar:

Erhan ÖNALAN | Yusuf GOKALP

Ana Başlıklar:

Hastalıklar

Dergi:

Family Practice and Palliative Care 2020 Vol.5 Issue 1, pp.1-5

Belge Tipi:

Makale

Yayın Tarihi:

1/2020

Belge Dili:

İngilizce

Document ID (Org No.):

2000429358

DOI:

https://doi.org/10.22391/fppc.634197