Short communication expression of glial fibrillary acidic protein in some tumors of dogs

Fehmi ARIKAN; Hamdi UYSAL

Makale detayları

Short communication expression of glial fibrillary acidic protein in some tumors of dogs

Yazarlar:

Fehmi ARIKAN | Hamdi UYSAL

Yayıncı:

Veteriner Hekimler Derneği

Dergi:

Journal of Turkish Veterinary Medical Society 2011 Vol.82 Issue 1, pp.23-27

Belge Tipi:

Makale

Yayın Tarihi:

12/2010

Belge Dili:

Türkçe

Document ID (Org No.):

2000685357

Sıklık:

İki Yıllık

eISSN:

2651-4214

pISSN:

0377-6395

Özet:

 

Glial Fibrillary Acidic Protein (GFAP) is an intermediate filament protein in astrocytes of the Central Nervous System that has a molecular weight of approximately 50 kDa. GFAP, as an antigen in nervous tissue identification, is used as a reliable immunohistochemical marker for glial neoplastic cells and benign astrocytoma cells. In veterinary medicine breast cancers, skin neoplasms and lymphatic tumors are frequent. In scientific literatures it has been made clear that GFAP is a remarkable marker for the normal and neoplastic glial cells nevertheless there is no information about GFAP as a marker for the tumors not generally considered to be of glial origin. Therefore, in this study to determine GFAP in the several dog tumors except glial neoplasms was intended. The results of Sodium Dodecyl Sulfate Polyacrylamide Gel Electroforesis (SDS-PAGE) and Semi-Dry Blotting analysis using antibody for GFAP (immunoblotting) showed that GFAP is not being expressed by the 14 tumors which we studied. It has been observed that GFAP expression is in enough amount in the brain tissues. The fact that GFAP has not been identified in the tumor tissues we analyzed points out that this protein is specific to nervous system tissues.

 

Glial Fibriler Asidik Protein (GFAP), molekül ağırlığı 50 kDa olan merkezi sinir sistemine ait astrositlerin intermediyer filament bir proteinidir. Sinir dokusunun tanımlanmasında bir antijen olarak kullanılan GFAP, merkezi sinir sisteminde.

Makale detayları

Short communication expression of glial fibrillary acidic protein in some tumors of dogs

Yazarlar: Fehmi ARIKAN | Hamdi UYSAL

Yayıncı: Veteriner Hekimler Derneği

Dergi: Journal of Turkish Veterinary Medical Society 2011 Vol.82 Issue 1, pp.23-27

Belge Tipi: Makale

Yayın Tarihi: 12/2010

Belge Dili: Türkçe

Document ID (Org No.): 2000685357

Sıklık: İki Yıllık

eISSN: 2651-4214

pISSN: 0377-6395

Sayı

Yazarlar:

Fehmi ARIKAN | Hamdi UYSAL

Yayıncı:

Veteriner Hekimler Derneği

Dergi:

Journal of Turkish Veterinary Medical Society 2011 Vol.82 Issue 1, pp.23-27

Belge Tipi:

Makale

Yayın Tarihi:

12/2010

Belge Dili:

Türkçe

Document ID (Org No.):

2000685357

Sıklık:

İki Yıllık

eISSN:

2651-4214

pISSN:

0377-6395