TRPV1 channel is a potential drug discovery channel for epilepsy

Ahmet ÖZŞİMŞEK

doi:https://doi.org/10.37212/jcnos.610113

Makale detayları

TRPV1 channel is a potential drug discovery channel for epilepsy

Yazarlar:

Ahmet ÖZŞİMŞEK

Yayıncı:

Hücresel Sinir Bilimleri ve Oksidatif Stres Derneği

Ana Başlıklar:

Hastalıklar

Dergi:

Journal of Cellular Neuroscience and Oxidative Stress 2018 Vol.10 Issue 3, pp.786-786

Belge Tipi:

Makale

Yayın Tarihi:

8/2018

Belge Dili:

İngilizce

Document ID (Org No.):

2000708846

Sıklık:

Üç Yıllık

eISSN:

2149-7222

DOI:

https://doi.org/10.37212/jcnos.610113

Özet:

 


Epilepsy is one of the most frequent and heterogeneous neurological disorders and it is characterized by several disabilities. Epilepsy is affecting about 3% of people worldwide. Current antiepileptic drugs are only effective in 60% of individuals and many drugs can induce several unwanted side effects in patients. Etiology of epilepsy has not been clarified fully. However, increased intracellular calcium ion (Ca2+) concentration has main role in etiology of epilepsy. Ca2+ passes the cell membrane through different cell membrane channels. One of the channels is TRP superfamily. The family is containing six subfamilies. TRPV1 channel is a member of TRPV subfamily. Capsaicin is a component of hot chili pepper. The TRPV1 channels is activated by different stimuli such as acidic pH, high temperature (≥ 42° C) and capsaicin, causing pain, inflammation and hyperalgesia in peripheral nervous system (Caterina et al. 1997). Is has been well known that hippocampus is main area in the brain for induction of epilepsy. Expression levels of TRPV1 channels in different areas of hippocampus are high (Gonzalez-Reyes et al. 2013). Results of recent studies indicated involvement of TRPV1 channels in epilepsy (Nazıroğlu and Övey, 2015; Cho et al. 2018). In the oral presentation, I discussed novel roles of TRPV1 on the epilepsy induction by the capsaicin. Results of a recent study indicated increased levels of intracellular Ca2+ concentration in hippocampus of epilepsy induced rats (Nazıroğlu and Övey, 2015). They also observed increased levels of intracellular mitochondrial oxidative stress and apoptosis levels in the neurons by the capsaicin stimulation. However, their levels were decreased by inhibition of TRPV1 channel blocker, capsazepine. I concluded that the results of recent studies suggest that TRPV1 stimulation through capsaicin causes oxidative stress and  intracellular Ca2+ signaling in epileptic rats. It seems to that the certain role of TRPV1 channel activation in in the epilepsy still remains to be determined.

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Makale detayları

TRPV1 channel is a potential drug discovery channel for epilepsy

Yazarlar: Ahmet ÖZŞİMŞEK

Yayıncı: Hücresel Sinir Bilimleri ve Oksidatif Stres Derneği

Ana Başlıklar: Hastalıklar

Dergi: Journal of Cellular Neuroscience and Oxidative Stress 2018 Vol.10 Issue 3, pp.786-786

Belge Tipi: Makale

Yayın Tarihi: 8/2018

Belge Dili: İngilizce

Document ID (Org No.): 2000708846

Sıklık: Üç Yıllık

eISSN: 2149-7222

DOI: https://doi.org/10.37212/jcnos.610113

Sayı

Yazarlar:

Ahmet ÖZŞİMŞEK

Yayıncı:

Hücresel Sinir Bilimleri ve Oksidatif Stres Derneği

Ana Başlıklar:

Hastalıklar

Dergi:

Journal of Cellular Neuroscience and Oxidative Stress 2018 Vol.10 Issue 3, pp.786-786

Belge Tipi:

Makale

Yayın Tarihi:

8/2018

Belge Dili:

İngilizce

Document ID (Org No.):

2000708846

Sıklık:

Üç Yıllık

eISSN:

2149-7222

DOI:

https://doi.org/10.37212/jcnos.610113