G6PD Deficiency Resulting In Massive Hemolysis and Acute Renal Failure: A Case Report

Merve EREN DURMUŞ; İbrahim Şenel YALÇIN; Yasin ŞAHİNTÜRK

Makale detayları

G6PD Deficiency Resulting In Massive Hemolysis and Acute Renal Failure: A Case Report

Yazarlar:

Merve EREN DURMUŞ | İbrahim Şenel YALÇIN | Yasin ŞAHİNTÜRK

Yayıncı:

DAHUDER

Ana Başlıklar:

Hastalıklar

Dergi:

DAHUDER Medical Journal 2021 Vol.1 Issue 1, pp.25-29

Belge Tipi:

Makale

Yayın Tarihi:

10/2021

Belge Dili:

İngilizce

Document ID (Org No.):

2000772842

Sıklık:

Üç Aylık

eISSN:

2791-9250

Özet:

 

Glucose 6 phosphate dehydrogenase (G6PD) is an intracellular enzyme that protects cells from oxidative stress by catalyzing the first step of penthose phosphate pathway. Since erythrocytes do not have mitochondria, pentose phosphate pathway is the only resource for NADPH production. Decreased NADPH production in G6PD deficient erythrocytes, results in susceptibility to oxidative damage and hemolysis eventually. G6PD deficiency is an X linked hereditary disorder and the most common enzyme deficiency in the world. Since the patients who have G6PD deficiency may be asymptomatic the actual incidence cannot be estimated. Usually hemolytic episodes resolves itself. However, in some cases it may end up with severe complications such as acute renal failure. 
A 43 year old male patient was admitted to our emergency department with jaundice. His complete blood count and biochemical test results were consistent with acute hemolysis; further diagnostic tests evaluating hemolytic anemia, low G6PD levels indicated that G6PD deficiency is the most probable etiology. When a more detailed anamnesis obtained, it is learned that the patient had eaten fava beans for the first time in his life. Since the patient was anuric and his renal function tests were worsening, we planned hemodialysis, several transfusions and therapeutic plasma exchange (TPE). Our case is a rare one in which severe hemolysis and acute renal failure developed following fava ingestion due to G6PD deficiency and TPE and hemolysis were successful.

Makale detayları

G6PD Deficiency Resulting In Massive Hemolysis and Acute Renal Failure: A Case Report

Yazarlar: Merve EREN DURMUŞ | İbrahim Şenel YALÇIN | Yasin ŞAHİNTÜRK

Yayıncı: DAHUDER

Ana Başlıklar: Hastalıklar

Dergi: DAHUDER Medical Journal 2021 Vol.1 Issue 1, pp.25-29

Belge Tipi: Makale

Yayın Tarihi: 10/2021

Belge Dili: İngilizce

Document ID (Org No.): 2000772842

Sıklık: Üç Aylık

eISSN: 2791-9250

Sayı

Yazarlar:

Merve EREN DURMUŞ | İbrahim Şenel YALÇIN | Yasin ŞAHİNTÜRK

Yayıncı:

DAHUDER

Ana Başlıklar:

Hastalıklar

Dergi:

DAHUDER Medical Journal 2021 Vol.1 Issue 1, pp.25-29

Belge Tipi:

Makale

Yayın Tarihi:

10/2021

Belge Dili:

İngilizce

Document ID (Org No.):

2000772842

Sıklık:

Üç Aylık

eISSN:

2791-9250