Acute Kidney Injury Is Associated With In-Hospital Mortality of Patients with COVID-19, But Less Common Among Variant B.1.1.7 Positive SARS-Cov-2 Infection

Demet Yavuz; Nezaket Kadı; Düriye Sıla Karagöz Özen; Melek Bilgin; Mehmet Derya Demirag

Makale detayları

Acute Kidney Injury Is Associated With In-Hospital Mortality of Patients with COVID-19, But Less Common Among Variant B.1.1.7 Positive SARS-Cov-2 Infection

Yazarlar:

Demet Yavuz | Nezaket Kadı | Düriye Sıla Karagöz Özen | Melek Bilgin | Mehmet Derya Demirag

Yayıncı:

Karyay Karadeniz Yayımcılık

Ana Başlıklar:

İç Hastalıkları

Dergi:

Black Sea Journal of Health Science Vol.6 Issue 4, pp.625-631

Belge Tipi:

Makale

Yayın Tarihi:

10/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001290971

pISSN:

2619-9041

Anahtar kelimeler:

Özet:

 The aim of this study is to compare the rates of acute kidney injury AKI occurence and mortality between hospitalized patients with SARS-CoV-2 infection variant B.1.1.7 positive and negative. 200 hospitalized patients with SARS-CoV-2 infection included in the study. The sociodemographic characteristics of the patients and the laboratory values were obtained retrospectively from the patient files and electronic records. 121 patients with variant B.1.1.7 positive SARS-CoV-2 group I and 79 patients with variant B.1.1.7 negative SARS-CoV-2 group II included in the study. Acute kidney injury developed at a higher rate in group II patients 1579 19, compared to group I patients 7121 5.8 P0.004. When 180 patients without chronic kidney disease included in the analysis, acute kidney injury developed in 7 6.4 of 110 variant-positive patients, while acute kidney injury developed in 13 18.6 of 70 variant-negative patients P0.011. It was shown that, AKI development was lower in variant positive patients compared to variant negative patients OR: 0.32 and 95 CI: 0.12  0.88, P0.027 and age was an independent risk factor for AKI OR: 1.06 and 95 CI: 1.02  1.11, P0.002. The development of AKI, presence of pre-dialysis chronic kidney disease and age were found to be independent risk factors for mortality respectively OR: 6.09 and 95 CI: 1.64  22.58, P0.005, OR: 5.37 and 95 CI: 1.38  20.93, P0.016, OR: 1.06 and 95 CI: 1.02  1.11, P0.005.

 The aim of this study is to compare the rates of acute kidney injury AKI occurence and mortality between hospitalized patients with SARS-CoV-2 infection variant B.1.1.7 positive and negative. 200 hospitalized patients with SARS-CoV-2 infection included in the study. The sociodemographic characteristics of the patients and the laboratory values were obtained retrospectively from the patient files and electronic records. 121 patients with variant B.1.1.7 positive SARS-CoV-2 group I and 79 patients with variant B.1.1.7 negative SARS-CoV-2 group II included in the study. Acute kidney injury developed at a higher rate in group II patients 1579 19, compared to group I patients 7121 5.8 P0.004. When 180 patients without chronic kidney disease included in the analysis, acute kidney injury developed in 7 6.4 of 110 variant-positive patients, while acute kidney injury developed in 13 18.6 of 70 variant-negative patients P0.011. It was shown that, AKI development was lower in variant positive patients compared to variant negative patients OR: 0.32 and 95 CI: 0.12  0.88, P0.027 and age was an independent risk factor for AKI OR: 1.06 and 95 CI: 1.02  1.11, P0.002. The development of AKI, presence of pre-dialysis chronic kidney disease and age were found to be independent risk factors for mortality respectively OR: 6.09 and 95 CI: 1.64  22.58, P0.005, OR: 5.37 and 95 CI: 1.38  20.93, P0.016, OR: 1.06 and 95 CI: 1.02  1.11, P0.005.

 The aim of this study is to compare the rates of acute kidney injury AKI occurence and mortality between hospitalized patients with SARS-CoV-2 infection variant B.1.1.7 positive and negative. 200 hospitalized patients with SARS-CoV-2 infection included in the study. The sociodemographic characteristics of the patients and the laboratory values were obtained retrospectively from the patient files and electronic records. 121 patients with variant B.1.1.7 positive SARS-CoV-2 group I and 79 patients with variant B.1.1.7 negative SARS-CoV-2 group II included in the study. Acute kidney injury developed at a higher rate in group II patients 1579 19, compared to group I patients 7121 5.8 P0.004. When 180 patients without chronic kidney disease included in the analysis, acute kidney injury developed in 7 6.4 of 110 variant-positive patients, while acute kidney injury developed in 13 18.6 of 70 variant-negative patients P0.011. It was shown that, AKI development was lower in variant positive patients compared to variant negative patients OR: 0.32 and 95 CI: 0.12  0.88, P0.027 and age was an independent risk factor for AKI OR: 1.06 and 95 CI: 1.02  1.11, P0.002. The development of AKI, presence of pre-dialysis chronic kidney disease and age were found to be independent risk factors for mortality respectively OR: 6.09 and 95 CI: 1.64  22.58, P0.005, OR: 5.37 and 95 CI: 1.38  20.93, P0.016, OR: 1.06 and 95 CI: 1.02  1.11, P0.005.

 The aim of this study is to compare the rates of acute kidney injury AKI occurence and mortality between hospitalized patients with SARS-CoV-2 infection variant B.1.1.7 positive and negative. 200 hospitalized patients with SARS-CoV-2 infection included in the study. The sociodemographic characteristics of the patients and the laboratory values were obtained retrospectively from the patient files and electronic records. 121 patients with variant B.1.1.7 positive SARS-CoV-2 group I and 79 patients with variant B.1.1.7 negative SARS-CoV-2 group II included in the study. Acute kidney injury developed at a higher rate in group II patients 1579 19, compared to group I patients 7121 5.8 P0.004. When 180 patients without chronic kidney disease included in the analysis, acute kidney injury developed in 7 6.4 of 110 variant-positive patients, while acute kidney injury developed in 13 18.6 of 70 variant-negative patients P0.011. It was shown that, AKI development was lower in variant positive patients compared to variant negative patients OR: 0.32 and 95 CI: 0.12  0.88, P0.027 and age was an independent risk factor for AKI OR: 1.06 and 95 CI: 1.02  1.11, P0.002. The development of AKI, presence of pre-dialysis chronic kidney disease and age were found to be independent risk factors for mortality respectively OR: 6.09 and 95 CI: 1.64  22.58, P0.005, OR: 5.37 and 95 CI: 1.38  20.93, P0.016, OR: 1.06 and 95 CI: 1.02  1.11, P0.005.

Makale detayları

Acute Kidney Injury Is Associated With In-Hospital Mortality of Patients with COVID-19, But Less Common Among Variant B.1.1.7 Positive SARS-Cov-2 Infection

Yazarlar:

Demet Yavuz | Nezaket Kadı | Düriye Sıla Karagöz Özen | Melek Bilgin | Mehmet Derya Demirag

Yayıncı:

Karyay Karadeniz Yayımcılık

Ana Başlıklar:

İç Hastalıkları

Dergi:

Black Sea Journal of Health Science Vol.6 Issue 4, pp.625-631

Belge Tipi:

Makale

Yayın Tarihi:

10/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001290971

pISSN:

2619-9041

Acute kidney injury

Mortality

SARS-CoV-2

Variant B.1.1.7Acute kidney injury

Mortality

SARS-CoV-2

Variant B.1.1.7

Sayı

Makale detayları

Yazarlar: Demet Yavuz | Nezaket Kadı | Düriye Sıla Karagöz Özen | Melek Bilgin | Mehmet Derya Demirag

Yayıncı: Karyay Karadeniz Yayımcılık

Ana Başlıklar: İç Hastalıkları

Dergi: Black Sea Journal of Health Science Vol.6 Issue 4, pp.625-631

Belge Tipi: Makale

Yayın Tarihi: 10/2023

Belge Dili: İngilizce

Document ID (Org No.): 2001290971

pISSN: 2619-9041

Sayı

Yazarlar:

Demet Yavuz | Nezaket Kadı | Düriye Sıla Karagöz Özen | Melek Bilgin | Mehmet Derya Demirag

Yayıncı:

Karyay Karadeniz Yayımcılık

Ana Başlıklar:

İç Hastalıkları

Dergi:

Black Sea Journal of Health Science Vol.6 Issue 4, pp.625-631

Belge Tipi:

Makale

Yayın Tarihi:

10/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001290971

pISSN:

2619-9041