The Effect of Coenzyme Q10 on Vestibular Compensation Process after Unilateral Labyrinthectomy in Rats Using Behavioral Tests

Ayşe ÇEÇEN; Rıfat KARLI; Asude ÜNAL

doi:https://doi.org/10.26650/Tr-ENT.2021.1016110

Makale detayları

The Effect of Coenzyme Q10 on Vestibular Compensation Process after Unilateral Labyrinthectomy in Rats Using Behavioral Tests

Yazarlar:

Ayşe ÇEÇEN | Rıfat KARLI | Asude ÜNAL

Yayıncı:

Istanbul University

Ana Başlıklar:

Cerrahi ve ilgili tıbbi uzmanlıklar

Dergi:

The Turkish Journal of Ear Nose and Throat 2022 Vol.32 Issue 1, pp.5-12

Belge Tipi:

Makale

Yayın Tarihi:

3/2022

Belge Dili:

İngilizce

Document ID (Org No.):

2000805553

Sıklık:

Üç Aylık

eISSN:

2602-4837

DOI:

https://doi.org/10.26650/Tr-ENT.2021.1016110

Özet:

 


Objective: To determine the effect of coenzyme Q10 on the vestibular compensation process after unilateral labyrinthectomy.

Material and Methods: Thirty Wistar rats were randomly assigned to 3 equal groups: the negative control group, the experimental group and the control  group.  Labyrinthectomy  surgeries  were  performed  in  all  3  groups.  After  the  labyrinthectomy,  findings  such  as  nystagmus  with  its  fast  phase  directed  to  the  undamaged  side,  deviation  of  the  head  to  the  side  operated  on,  impairment  in  walking,  and  decreased  tonus  of  the  extensor muscles on the same side were observed.

Results: The values of Group EG and Group CG were somewhat higher than those of Group NCG in terms of the degree of head tilt, but there was no statistically significant difference among the three groups. Although Group EG and Group CG were found to differ statistically significantly from Group NCG on certain days in terms of postural deficit values and nystagmus, this significance remained limited to those particular days.

Conclusion:  The  effect  of  CoQ10  on  the  vestibular  compensation  process  was  limited  may  be  due  to  its  limited  dose,  short  duration  of  administration, and the limited number of rats. We believe that the effects of CoQ10 on the vestibular compensation process after labyrinthectomy should not be neglected. Despite the fact that we administered it at limited doses for a short term on a limited number of rats, CoQ10 should be used in larger samples, in higher doses, and for a longer time because CoQ10 has positive, though limited effects, on the vestibular compensation process

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Makale detayları

The Effect of Coenzyme Q10 on Vestibular Compensation Process after Unilateral Labyrinthectomy in Rats Using Behavioral Tests

Yazarlar: Ayşe ÇEÇEN | Rıfat KARLI | Asude ÜNAL

Yayıncı: Istanbul University

Ana Başlıklar: Cerrahi ve ilgili tıbbi uzmanlıklar

Dergi: The Turkish Journal of Ear Nose and Throat 2022 Vol.32 Issue 1, pp.5-12

Belge Tipi: Makale

Yayın Tarihi: 3/2022

Belge Dili: İngilizce

Document ID (Org No.): 2000805553

Sıklık: Üç Aylık

eISSN: 2602-4837

DOI: https://doi.org/10.26650/Tr-ENT.2021.1016110

Sayı

Yazarlar:

Ayşe ÇEÇEN | Rıfat KARLI | Asude ÜNAL

Yayıncı:

Istanbul University

Ana Başlıklar:

Cerrahi ve ilgili tıbbi uzmanlıklar

Dergi:

The Turkish Journal of Ear Nose and Throat 2022 Vol.32 Issue 1, pp.5-12

Belge Tipi:

Makale

Yayın Tarihi:

3/2022

Belge Dili:

İngilizce

Document ID (Org No.):

2000805553

Sıklık:

Üç Aylık

eISSN:

2602-4837

DOI:

https://doi.org/10.26650/Tr-ENT.2021.1016110