INHIBITION OF NITRIC OXIDE SYNTHESIS AMELIORATES BURN-INDUCED REMOTE ORGAN INJURY IN RATS: A LIGHT MICROSCOPIC STUDY

Özlem Güneysel; Berna Oktar; Berrak Yeğen; Cumhur Yeğen; Serap Arbak

Makale detayları

INHIBITION OF NITRIC OXIDE SYNTHESIS AMELIORATES BURN-INDUCED REMOTE ORGAN INJURY IN RATS: A LIGHT MICROSCOPIC STUDY

Yazarlar:

Özlem Güneysel | Berna Oktar | Berrak Yeğen | Cumhur Yeğen | Serap Arbak

Yayıncı:

Marmara University

Dergi:

Marmara Medical Journal 2002 Vol.15 Issue 3, pp.155-160

Belge Tipi:

Makale

Yayın Tarihi:

12/2016

Belge Dili:

Türkçe

Document ID (Org No.):

2000546399

Sıklık:

Aylık

eISSN:

1309-9469

pISSN:

1019-1941

Özet:

 


Objective: To investigate the role of endogenous nitric oxide (NO) on remote organ injury in the early phase of burn trauma.Methods: Wistar albino rats (200-300 g) were exposed to 90°C (burn) or 25°C (sham) water bath for 10 sec.Results: Microscopic score in the stomach was increased in the burn group compared to sham. Hemorrhage areas, epithelial desquamation and glandular cell degeneration were observed in the gastric mucosa of the burn group. NG-nitro-L- arginine methyl ester (L-NAME) treatment reduced the burn-induced damage score with an intact glandular architecture. In NG-nitro-D- arginine methyl ester (D-NAME) pretreated groups, histologic scores were not different than burn group, with desquamated and degenerated surface epithelium. L-arginine (L-arg) plus L- NAME pretreatment partially reversed this effect with prominent gastric mucosal damage. In the liver, the microscopic score was increased in the burn group compared to sham. Hepatocytevacuolar degeneration, sinusoidal congestion and increased number of Kupffer cells were observed in the burn group. Hepatic injury was slightly attenuated by L-NAME treatment whereas D-NAME or L-arg plus L-NAME pretreatment was ineffective.Conclusion: In conclusion, inhibition of NO synthesis ameliorates gastric and hepatic damage, emphasizing the critical role of NO in the burn-induced remote organ injury.Key Words: Burns, Nitric oxide, Remote organ injury, Myeloperoxidase activity

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Makale detayları

INHIBITION OF NITRIC OXIDE SYNTHESIS AMELIORATES BURN-INDUCED REMOTE ORGAN INJURY IN RATS: A LIGHT MICROSCOPIC STUDY

Yazarlar: Özlem Güneysel | Berna Oktar | Berrak Yeğen | Cumhur Yeğen | Serap Arbak

Yayıncı: Marmara University

Dergi: Marmara Medical Journal 2002 Vol.15 Issue 3, pp.155-160

Belge Tipi: Makale

Yayın Tarihi: 12/2016

Belge Dili: Türkçe

Document ID (Org No.): 2000546399

Sıklık: Aylık

eISSN: 1309-9469

pISSN: 1019-1941

Sayı

Yazarlar:

Özlem Güneysel | Berna Oktar | Berrak Yeğen | Cumhur Yeğen | Serap Arbak

Yayıncı:

Marmara University

Dergi:

Marmara Medical Journal 2002 Vol.15 Issue 3, pp.155-160

Belge Tipi:

Makale

Yayın Tarihi:

12/2016

Belge Dili:

Türkçe

Document ID (Org No.):

2000546399

Sıklık:

Aylık

eISSN:

1309-9469

pISSN:

1019-1941