Development of pancytopenia after single low-dose methotrexate therapy in patients with chronic kidney disease: a review of the literature

İbrahim AKDAĞ; Alparslan ERSOY

doi:https://doi.org/10.46310/tjim.766086

Makale detayları

Development of pancytopenia after single low-dose methotrexate therapy in patients with chronic kidney disease: a review of the literature

Yazarlar:

İbrahim AKDAĞ | Alparslan ERSOY

Yayıncı:

Nizameddin KOCA

Ana Başlıklar:

Hastalıklar

Dergi:

Turkish Journal of Internal Medicine 2020 Vol.2 Issue 3, pp.83-90

Belge Tipi:

Makale

Yayın Tarihi:

7/2020

Belge Dili:

İngilizce

Document ID (Org No.):

2000637860

Sıklık:

Üç Aylık

eISSN:

2687-4245

DOI:

https://doi.org/10.46310/tjim.766086

Özet:

 

Methotrexate (MTX) is widely used in the treatment of both rheumatoid arthritis (RA) and psoriatic arthritis (PA) with a side effect of pancytopenia. However, very few cases of severe pancytopenia caused by low-dose MTX therapy have been described in chronic kidney disease. Pancytopenia occurred after using a single dose of MTX in three patients with chronic kidney dysfunction. While one patient died due to sepsis and multiple organ failure, the others recovered. The severity of MTX-inducedpancytopenia in our cases was likely related to the underlyingkidney disease. These cases suggest that uremic patients may develop severe fatal bone marrow toxicity even with a single dose of MTX. Therefore, close blood count monitoring after MTX treatment in this population would be beneficial.

Makale detayları

Development of pancytopenia after single low-dose methotrexate therapy in patients with chronic kidney disease: a review of the literature

Yazarlar: İbrahim AKDAĞ | Alparslan ERSOY

Yayıncı: Nizameddin KOCA

Ana Başlıklar: Hastalıklar

Dergi: Turkish Journal of Internal Medicine 2020 Vol.2 Issue 3, pp.83-90

Belge Tipi: Makale

Yayın Tarihi: 7/2020

Belge Dili: İngilizce

Document ID (Org No.): 2000637860

Sıklık: Üç Aylık

eISSN: 2687-4245

DOI: https://doi.org/10.46310/tjim.766086

Sayı

Yazarlar:

İbrahim AKDAĞ | Alparslan ERSOY

Yayıncı:

Nizameddin KOCA

Ana Başlıklar:

Hastalıklar

Dergi:

Turkish Journal of Internal Medicine 2020 Vol.2 Issue 3, pp.83-90

Belge Tipi:

Makale

Yayın Tarihi:

7/2020

Belge Dili:

İngilizce

Document ID (Org No.):

2000637860

Sıklık:

Üç Aylık

eISSN:

2687-4245

DOI:

https://doi.org/10.46310/tjim.766086