Evaluation of Thyroid Disorders in Effectively Treated Acromegalic Patients

Abdullatif Sirin; Osman Köstek; Mümtaz Takır; Mehmet Uzunlulu

Makale detayları

Evaluation of Thyroid Disorders in Effectively Treated Acromegalic Patients

Yazarlar:

Abdullatif Sirin | Osman Köstek | Mümtaz Takır | Mehmet Uzunlulu

Yayıncı:

Yozgat Bozok University

Ana Başlıklar:

Endokrinoloji

Dergi:

Bozok Tıp Dergisi Vol.15 Issue 2, pp.119-124

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001350365

pISSN:

2146-4006

Anahtar kelimeler:

Özet:

 Abstract Objective: Acromegaly patients often develop goiter and thyroid nodules due to continuous stimulation of the thyroid follicle by growth hormon GH and insulin-like growth factor-1 IGF-1. Recent studies suggest a decrease in thyroid disease rates in patients who have been successfully treated. This study aimed to investigate thyroid disorders in patients who had cured or controlled the disease. Material and Methods: The patients GH levels less than 1 ngmL and IGF-1 levels within the age-sex-adjusted normal range were categorized into controlled patients. Sonographic and biochemical findings of the thyroid gland were recorded. Results: The study included 33 patients with acromegaly 14 males and 19 females and 50 volunteers 14 males and 36 females. The prevalence of goiter was higher in patients with acromegaly compared to control group 21.2 vs. 6, respectively; p0.001. Acromegaly patients had a higher frequency of thyroid nodules, but nodules larger than 1 cm were similar between the two groups. Conclusion: Acromegaly patients still have a high multinodular goiter incidence. Well control of disease may reduce the prevelance of thyroid cancer and risky nodules. acromegaly, thyroid disease, thyroid nodule.

 Abstract Objective: Acromegaly patients often develop goiter and thyroid nodules due to continuous stimulation of the thyroid follicle by growth hormon GH and insulin-like growth factor-1 IGF-1. Recent studies suggest a decrease in thyroid disease rates in patients who have been successfully treated. This study aimed to investigate thyroid disorders in patients who had cured or controlled the disease. Material and Methods: The patients GH levels less than 1 ngmL and IGF-1 levels within the age-sex-adjusted normal range were categorized into controlled patients. Sonographic and biochemical findings of the thyroid gland were recorded. Results: The study included 33 patients with acromegaly 14 males and 19 females and 50 volunteers 14 males and 36 females. The prevalence of goiter was higher in patients with acromegaly compared to control group 21.2 vs. 6, respectively; p0.001. Acromegaly patients had a higher frequency of thyroid nodules, but nodules larger than 1 cm were similar between the two groups. Conclusion: Acromegaly patients still have a high multinodular goiter incidence. Well control of disease may reduce the prevelance of thyroid cancer and risky nodules. acromegaly, thyroid disease, thyroid nodule.

 Abstract Objective: Acromegaly patients often develop goiter and thyroid nodules due to continuous stimulation of the thyroid follicle by growth hormon GH and insulin-like growth factor-1 IGF-1. Recent studies suggest a decrease in thyroid disease rates in patients who have been successfully treated. This study aimed to investigate thyroid disorders in patients who had cured or controlled the disease. Material and Methods: The patients GH levels less than 1 ngmL and IGF-1 levels within the age-sex-adjusted normal range were categorized into controlled patients. Sonographic and biochemical findings of the thyroid gland were recorded. Results: The study included 33 patients with acromegaly 14 males and 19 females and 50 volunteers 14 males and 36 females. The prevalence of goiter was higher in patients with acromegaly compared to control group 21.2 vs. 6, respectively; p0.001. Acromegaly patients had a higher frequency of thyroid nodules, but nodules larger than 1 cm were similar between the two groups. Conclusion: Acromegaly patients still have a high multinodular goiter incidence. Well control of disease may reduce the prevelance of thyroid cancer and risky nodules. acromegaly, thyroid disease, thyroid nodule.

 Giriş: Tiroid foliküllerinin growth hormon GH ve insülin-like growth faktör-1 IGF-1 aracılığıyla sürekli uyarılması akromegali hastalarında guatr ve tiroid nodüllerinin gelişmesine neden olur. Güncel çalışmalar, başarılı şekilde tedavi edilen hastalarda tiroid hastalığı sıklığının azaldığını ileri sürmektedir. Bu çalışma, kür veya kontrol altına alınmış hastalardaki tiroid bozukluklarını araştırmak için yapılmıştır. Gereç ve Yöntemler: GH düzeyleri 1ngmLden düşük ve IGF-1 seviyeleri yaşa ve cinsiyete göre normal aralıkta olan hastalar kontrol altına alınmış hastalar olarak kategorize edildi. Tiroid bezinin sonografik ve biyokimyasal bulguları kaydedildi. Bulgular: Çalışmada 33 akromegali hastası 14 erkek ve 19 kadın ve 50 gönüllü yer aldı. 14 erkekve 36 kadın. Akromegali hastalarındaki guatr sıklığı kontrol grubuna kıyasla daha fazla idi sırasıyla, 21.2 ve 6, p0.001. Akromegali hastalarında tiroid nodülü daha sık görülmekle beraber 1 cmden büyük nodül sıklığı iki grup arasında benzerdi. Sonuç: Akromegali hastalarında multinodüler guatr sıklığı halen yüksektir. Hastalığın tam kontrol altına alınması tiroid kanseri ve riskli nodül sıklığını azaltabilir.

Makale detayları

Evaluation of Thyroid Disorders in Effectively Treated Acromegalic Patients

Yazarlar:

Abdullatif Sirin | Osman Köstek | Mümtaz Takır | Mehmet Uzunlulu

Yayıncı:

Yozgat Bozok University

Ana Başlıklar:

Endokrinoloji

Dergi:

Bozok Tıp Dergisi Vol.15 Issue 2, pp.119-124

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001350365

pISSN:

2146-4006

acromegaly

thyroid disease

thyroid noduleakromegali

tiroid hastalıkları

tiroid nodülü

Sayı

Makale detayları

Evaluation of Thyroid Disorders in Effectively Treated Acromegalic Patients

Yazarlar: Abdullatif Sirin | Osman Köstek | Mümtaz Takır | Mehmet Uzunlulu

Yayıncı: Yozgat Bozok University

Ana Başlıklar: Endokrinoloji

Dergi: Bozok Tıp Dergisi Vol.15 Issue 2, pp.119-124

Belge Tipi: Makale

Yayın Tarihi: 6/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001350365

pISSN: 2146-4006

acromegaly

thyroid disease

thyroid noduleakromegali

tiroid hastalıkları

tiroid nodülü

Sayı

Yazarlar:

Abdullatif Sirin | Osman Köstek | Mümtaz Takır | Mehmet Uzunlulu

Yayıncı:

Yozgat Bozok University

Ana Başlıklar:

Endokrinoloji

Dergi:

Bozok Tıp Dergisi Vol.15 Issue 2, pp.119-124

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001350365

pISSN:

2146-4006