Evaluation of the teratogenic effect of water extract of Sonchus arvensis L. and Anredera cordifolia (Ten.) Steenis leaves as a combination in Wistar rat

Nova Suliska

Makale detayları

Evaluation of the teratogenic effect of water extract of Sonchus arvensis L. and Anredera cordifolia (Ten.) Steenis leaves as a combination in Wistar rat

Yazarlar:

Nova Suliska

Yayıncı:

Marmara University

Ana Başlıklar:

Basic Pharmacology

Dergi:

Journal of Research in Pharmacy Vol.27 Issue 2, pp.762-768

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001347838

pISSN:

2630-6344

Anahtar kelimeler:

Özet:

 Water extract of Sonchus arvensis and Anredera cordifolia leaves as a combination has been proven for their antihypertensive activity, but there is no information about its safety for pregnant women yet. This experiment aimed to evaluate the teratogenic effect of water extract of S. arvensis and A. cordifolia leaves as a combination 1:1 at doses of 100 mgkg bw, 400 mgkg bw, and 1000 mgkg bw in Wistar rats. The extract was made into suspension in sodium carboxymethyl cellulose Na-CMC 0.5 and given orally to pregnant rats on gestation day 6-15 as much as 1 mL100 gram bw. Pregnant rats were sacrificed at gestation day 19. All parameters related to fetuses included the number of fetuses, fetal weight, skeletal and organ malformation were evaluated. The percentage of skeletal and organ malformation of each treatment groups was compared to the control group and analyzed with one-way ANOVA method using IBM SPSS 28. There was no significant difference in both average number and fetal weight from all treatment groups compared to the control group P0.05. Skeletal malformation was not found, but there were undeveloped fetuses resorption and some fetuses with small brains in all groups. The percentage of each treatment groups for those two conditions was not significantly different compared to the control group. Therefore, water extract of S. arvensis and A. cordifolia leaves as a combination at doses of 100 mgkg bw, 400 mgkg bw, and 1000 mgkg bw contraindicated for pregnant women and those who are planning on pregnancy.

 Water extract of Sonchus arvensis and Anredera cordifolia leaves as a combination has been proven for their antihypertensive activity, but there is no information about its safety for pregnant women yet. This experiment aimed to evaluate the teratogenic effect of water extract of S. arvensis and A. cordifolia leaves as a combination 1:1 at doses of 100 mgkg bw, 400 mgkg bw, and 1000 mgkg bw in Wistar rats. The extract was made into suspension in sodium carboxymethyl cellulose Na-CMC 0.5 and given orally to pregnant rats on gestation day 6-15 as much as 1 mL100 gram bw. Pregnant rats were sacrificed at gestation day 19. All parameters related to fetuses included the number of fetuses, fetal weight, skeletal and organ malformation were evaluated. The percentage of skeletal and organ malformation of each treatment groups was compared to the control group and analyzed with one-way ANOVA method using IBM SPSS 28. There was no significant difference in both average number and fetal weight from all treatment groups compared to the control group P0.05. Skeletal malformation was not found, but there were undeveloped fetuses resorption and some fetuses with small brains in all groups. The percentage of each treatment groups for those two conditions was not significantly different compared to the control group. Therefore, water extract of S. arvensis and A. cordifolia leaves as a combination at doses of 100 mgkg bw, 400 mgkg bw, and 1000 mgkg bw contraindicated for pregnant women and those who are planning on pregnancy.

 Water extract of Sonchus arvensis and Anredera cordifolia leaves as a combination has been proven for their antihypertensive activity, but there is no information about its safety for pregnant women yet. This experiment aimed to evaluate the teratogenic effect of water extract of S. arvensis and A. cordifolia leaves as a combination 1:1 at doses of 100 mgkg bw, 400 mgkg bw, and 1000 mgkg bw in Wistar rats. The extract was made into suspension in sodium carboxymethyl cellulose Na-CMC 0.5 and given orally to pregnant rats on gestation day 6-15 as much as 1 mL100 gram bw. Pregnant rats were sacrificed at gestation day 19. All parameters related to fetuses included the number of fetuses, fetal weight, skeletal and organ malformation were evaluated. The percentage of skeletal and organ malformation of each treatment groups was compared to the control group and analyzed with one-way ANOVA method using IBM SPSS 28. There was no significant difference in both average number and fetal weight from all treatment groups compared to the control group P0.05. Skeletal malformation was not found, but there were undeveloped fetuses resorption and some fetuses with small brains in all groups. The percentage of each treatment groups for those two conditions was not significantly different compared to the control group. Therefore, water extract of S. arvensis and A. cordifolia leaves as a combination at doses of 100 mgkg bw, 400 mgkg bw, and 1000 mgkg bw contraindicated for pregnant women and those who are planning on pregnancy.

 Water extract of Sonchus arvensis and Anredera cordifolia leaves as a combination has been proven for their antihypertensive activity, but there is no information about its safety for pregnant women yet. This experiment aimed to evaluate the teratogenic effect of water extract of S. arvensis and A. cordifolia leaves as a combination 1:1 at doses of 100 mgkg bw, 400 mgkg bw, and 1000 mgkg bw in Wistar rats. The extract was made into suspension in sodium carboxymethyl cellulose Na-CMC 0.5 and given orally to pregnant rats on gestation day 6-15 as much as 1 mL100 gram bw. Pregnant rats were sacrificed at gestation day 19. All parameters related to fetuses included the number of fetuses, fetal weight, skeletal and organ malformation were evaluated. The percentage of skeletal and organ malformation of each treatment groups was compared to the control group and analyzed with one-way ANOVA method using IBM SPSS 28. There was no significant difference in both average number and fetal weight from all treatment groups compared to the control group P0.05. Skeletal malformation was not found, but there were undeveloped fetuses resorption and some fetuses with small brains in all groups. The percentage of each treatment groups for those two conditions was not significantly different compared to the control group. Therefore, water extract of S. arvensis and A. cordifolia leaves as a combination at doses of 100 mgkg bw, 400 mgkg bw, and 1000 mgkg bw contraindicated for pregnant women and those who are planning on pregnancy.

Makale detayları

Evaluation of the teratogenic effect of water extract of Sonchus arvensis L. and Anredera cordifolia (Ten.) Steenis leaves as a combination in Wistar rat

Yazarlar:

Nova Suliska

Yayıncı:

Marmara University

Ana Başlıklar:

Basic Pharmacology

Dergi:

Journal of Research in Pharmacy Vol.27 Issue 2, pp.762-768

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001347838

pISSN:

2630-6344

S.arvensis

A.cordifolia

water leaves extract

antihypertensive activity

teratogenic effect

Sayı

Makale detayları

Evaluation of the teratogenic effect of water extract of Sonchus arvensis L. and Anredera cordifolia (Ten.) Steenis leaves as a combination in Wistar rat

Yazarlar: Nova Suliska

Yayıncı: Marmara University

Ana Başlıklar: Basic Pharmacology

Dergi: Journal of Research in Pharmacy Vol.27 Issue 2, pp.762-768

Belge Tipi: Makale

Yayın Tarihi: 6/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001347838

pISSN: 2630-6344

S.arvensis

A.cordifolia

water leaves extract

antihypertensive activity

teratogenic effect

Sayı

Yazarlar:

Nova Suliska

Yayıncı:

Marmara University

Ana Başlıklar:

Basic Pharmacology

Dergi:

Journal of Research in Pharmacy Vol.27 Issue 2, pp.762-768

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001347838

pISSN:

2630-6344