Association between the MUC4 g.243A > G polymorphism and immune and  production traits in Large White pigs

Ying LIU; Xue Mei YIN; Ri Wei XIA; Yong Jiu HUO; Guo Qiang ZHU; Sheng Long WU; Wen Bin BAO

Makale detayları

Association between the MUC4 g.243A > G polymorphism and immune and production traits in Large White pigs

Yazarlar:

Ying LIU | Xue Mei YIN | Ri Wei XIA | Yong Jiu HUO | Guo Qiang ZHU | Sheng Long WU | Wen Bin BAO

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Veterinary and Animal Sciences 2015 Vol.39 Issue 2, pp.141-146

Belge Tipi:

Makale

Yayın Tarihi:

8/2015

Belge Dili:

Türkçe

Document ID (Org No.):

2000765622

Sıklık:

İki Aylık

eISSN:

1303-6181

pISSN:

1300-0128

Anahtar kelimeler:

Özet:

 

PCR-RFLP analysis of intron 17 of the MUC4 gene was conducted in Large White pigs and associations with cytokine levels (IFN-?, IL-1Ã, IL-4, IL-6, IL-8, IL-10, TGF-Ã, and TNF-?), production traits (100-kg-weight day age, back-fat depth, and eye muscle depth), and reproductive performance within different litters (total number born, number born alive, number in live weaning litter) were analyzed with the aim of identifying genetic markers of disease resistance. The results revealed AA, AG, and GG genotypes, with an A243G mutation identified in the GG genotype. Correlation analysis indicated that IL-8 and IL-10 levels and 100-kg-weight day age were significantly higher in the GG genotype compared with AA and AG genotypes (P  0.05). These data indicate that MUC4 g.243A>G may enhance the antidisease capability and affect the growth rate of groups in the fattening period of Large White pigs without detrimental influences on resistance to disease, other production traits, and reproductive performance.

 

PCR-RFLP analysis of intron 17 of the MUC4 gene was conducted in Large White pigs and associations with cytokine levels (IFN-?, IL-1Ã, IL-4, IL-6, IL-8, IL-10, TGF-Ã, and TNF-?), production traits (100-kg-weight day age, back-fat depth, and eye muscle depth), and reproductive performance within different litters (total number born, number born alive, number in live weaning litter) were analyzed with the aim of identifying genetic markers of disease resistance. The results revealed AA, AG, and GG genotypes, with an A243G mutation identified in the GG genotype. Correlation analysis indicated that IL-8 and IL-10 levels and 100-kg-weight day age were significantly higher in the GG genotype compared with AA and AG genotypes (P  0.05). These data indicate that MUC4 g.243A>G may enhance the antidisease capability and affect the growth rate of groups in the fattening period of Large White pigs without detrimental influences on resistance to disease, other production traits, and reproductive performance.

Makale detayları

Association between the MUC4 g.243A > G polymorphism and immune and production traits in Large White pigs

Yazarlar:

Ying LIU | Xue Mei YIN | Ri Wei XIA | Yong Jiu HUO | Guo Qiang ZHU | Sheng Long WU | Wen Bin BAO

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Veterinary and Animal Sciences 2015 Vol.39 Issue 2, pp.141-146

Belge Tipi:

Makale

Yayın Tarihi:

8/2015

Belge Dili:

Türkçe

Document ID (Org No.):

2000765622

Sıklık:

İki Aylık

eISSN:

1303-6181

pISSN:

1300-0128

Swine

MUC4 gene

genetic marker

immunity index

economic traits

Sayı

Makale detayları

Association between the MUC4 g.243A > G polymorphism and immune and production traits in Large White pigs

Yazarlar: Ying LIU | Xue Mei YIN | Ri Wei XIA | Yong Jiu HUO | Guo Qiang ZHU | Sheng Long WU | Wen Bin BAO

Yayıncı: TUBITAK

Dergi: Turkish Journal of Veterinary and Animal Sciences 2015 Vol.39 Issue 2, pp.141-146

Belge Tipi: Makale

Yayın Tarihi: 8/2015

Belge Dili: Türkçe

Document ID (Org No.): 2000765622

Sıklık: İki Aylık

eISSN: 1303-6181

pISSN: 1300-0128

Swine

MUC4 gene

genetic marker

immunity index

economic traits

Sayı

Yazarlar:

Ying LIU | Xue Mei YIN | Ri Wei XIA | Yong Jiu HUO | Guo Qiang ZHU | Sheng Long WU | Wen Bin BAO

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Veterinary and Animal Sciences 2015 Vol.39 Issue 2, pp.141-146

Belge Tipi:

Makale

Yayın Tarihi:

8/2015

Belge Dili:

Türkçe

Document ID (Org No.):

2000765622

Sıklık:

İki Aylık

eISSN:

1303-6181

pISSN:

1300-0128