In silico and in vitro evaluation of the biological activity of some   organic sulfur-containing compounds

Victoria OSIPOVA; Maria POLOVINKINA; Anastasia OSIPOVA; Yulia GRACHEVA; Andrey OKHLOBYSTIN

Makale detayları

In silico and in vitro evaluation of the biological activity of some organic sulfur-containing compounds

Yazarlar:

Victoria OSIPOVA | Maria POLOVINKINA | Anastasia OSIPOVA | Yulia GRACHEVA | Andrey OKHLOBYSTIN

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Chemistry 2019 Vol.43 Issue 5, pp.1336-1349

Belge Tipi:

Makale

Yayın Tarihi:

9/2019

Belge Dili:

İngilizce

Document ID (Org No.):

2000725578

Sıklık:

İki Aylık

eISSN:

1303-6130

pISSN:

1300-0527

Özet:

 

It was predicted, using the Prediction of Activity   Spectra for Substances online software, that organic sulfur-containing   compounds 2,6-di-tert-butyl-4-mercaptophenol (1),   2,6-di-tert-butyl-4-(3-mercaptopropyl)phenol (2),   bis-3-[3,5-di-tert-butyl-4-hydroxyphenyl)propyl] sulfide (3),   bis(3,5-di-tert- butyl-4-hydroxyphenyl) disulfide (4), diphenyl disulfide   (5), dibenzyl disulfide (6), dibutyl disulfide   (7), di-tert-butyl disulfide (8), diallyl disulfide   (9), and methyl propyl trisulfide (10) could possess   antioxidant activity and act as active scavengers of oxygen metabolites. The   antiradical activity of these species was analyzed and it was shown that   they were able to react with electrochemically generated the superoxide   anion radical. The rate constants for reactions of 1-10 with the   superoxide anion radical were calculated. The effect of the organic sulfur   compounds on the rate of generation O−∙22−∙_{2}^{-\bullet } on adrenaline   oxidation in an alkaline medium and on the ability of the biopreparation,   based on the liver of Russian sturgeon, to deactivate O−∙22−∙_{2}^{-\bullet \,   }was studied. The effect of the organic sulfur compounds on the rate of   O−∙22−∙_{2}^{-\bullet } generation in the model system of the quinoid   oxidation of adrenaline in an alkaline medium and on the ability of the   biopreparation to deactivate O−∙22−∙_{2}^{-\bullet } was studied. It was found   that O−∙22−∙_{2}^{-\bullet } generation rate decreased in the presence of the   studied compounds, evidencing for their antiradical activity. Increase of   superoxide dismutation activity of the biopreparation in the presence of   compounds 1-10 was also shown, and this fact could indicate their   ability to increase the antioxidant status and decrease the probability of   oxidative stress development. It was found that compounds 1-10 did   not inhibit enzyme lipoxygenase, which indicated the absence of   antiinflammatory activity. The results of the forecast were consistent with   the data of the experimental studies.

Makale detayları

In silico and in vitro evaluation of the biological activity of some organic sulfur-containing compounds

Yazarlar: Victoria OSIPOVA | Maria POLOVINKINA | Anastasia OSIPOVA | Yulia GRACHEVA | Andrey OKHLOBYSTIN

Yayıncı: TUBITAK

Dergi: Turkish Journal of Chemistry 2019 Vol.43 Issue 5, pp.1336-1349

Belge Tipi: Makale

Yayın Tarihi: 9/2019

Belge Dili: İngilizce

Document ID (Org No.): 2000725578

Sıklık: İki Aylık

eISSN: 1303-6130

pISSN: 1300-0527

Sayı

Yazarlar:

Victoria OSIPOVA | Maria POLOVINKINA | Anastasia OSIPOVA | Yulia GRACHEVA | Andrey OKHLOBYSTIN

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Chemistry 2019 Vol.43 Issue 5, pp.1336-1349

Belge Tipi:

Makale

Yayın Tarihi:

9/2019

Belge Dili:

İngilizce

Document ID (Org No.):

2000725578

Sıklık:

İki Aylık

eISSN:

1303-6130

pISSN:

1300-0527