Smart in-situ thermo-responsive and ion activated ophthalmic sol-gel system of fluconazole

N.A.

Makale detayları

Smart in-situ thermo-responsive and ion activated ophthalmic sol-gel system of fluconazole

Yazarlar:

N.A.

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmaceutical Delivery Technologies

Dergi:

Journal of Research in Pharmacy Vol.25 Issue 2, pp.173-178

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001347809

pISSN:

2630-6344

Anahtar kelimeler:

Özet:

 The objective of the current investigation is the development and characterization of in-situ ophthalmic formulation of fluconazole for sustained release at the eye site for a prolong period of time. Sol-gel fluconazole in-situ formulation was prepared by thermo-responsive pluronic F127, Na activated sodium alginate alone and in combination, characterization parameters include FTIR spectroscopy, Visual assessment and clarity test, Gelling ability test, pH testing, drug assay, In-vitro drug release and optimized formulation was evaluated for In-vitro antifungal studies by comparing with marketed formulation of fluconazole. Optimized formulation F8 composed of fluconazole 0.3wv, Pluronic F1271wv, sodium alginate 0.5wv, sodium chloride 0.9wv, benzalkonium Chloride 0.01wv and acetate buffer pH 4 up to 100wv, showed drug-polymer compatibility as per FTIR, high gelling consistency on contact with simulated physiological conditions, 6.9 pH, drug assay was estimated 99.890.78  with 100 in-vitro drug released for about 6 hours. The in-vitro antifungal study was found to be 18.870.65 mm; 20.760.23 mm in comparison to marketed fluconazole conventional gel formulation 15.980.98 mm; 18.980.76 mm for Candida albicans and Aspergillus niger pathogenic fungal strains respectively. Prepared in-situ ophthalmic sol-gel formulation of fluconazole could be considered as efficient delivery system to sustained the drug at the target site and effectively eradicating deeply rooted pathogenic fungal stains.

 The objective of the current investigation is the development and characterization of in-situ ophthalmic formulation of fluconazole for sustained release at the eye site for a prolong period of time. Sol-gel fluconazole in-situ formulation was prepared by thermo-responsive pluronic F127, Na activated sodium alginate alone and in combination, characterization parameters include FTIR spectroscopy, Visual assessment and clarity test, Gelling ability test, pH testing, drug assay, In-vitro drug release and optimized formulation was evaluated for In-vitro antifungal studies by comparing with marketed formulation of fluconazole. Optimized formulation F8 composed of fluconazole 0.3wv, Pluronic F1271wv, sodium alginate 0.5wv, sodium chloride 0.9wv, benzalkonium Chloride 0.01wv and acetate buffer pH 4 up to 100wv, showed drug-polymer compatibility as per FTIR, high gelling consistency on contact with simulated physiological conditions, 6.9 pH, drug assay was estimated 99.890.78  with 100 in-vitro drug released for about 6 hours. The in-vitro antifungal study was found to be 18.870.65 mm; 20.760.23 mm in comparison to marketed fluconazole conventional gel formulation 15.980.98 mm; 18.980.76 mm for Candida albicans and Aspergillus niger pathogenic fungal strains respectively. Prepared in-situ ophthalmic sol-gel formulation of fluconazole could be considered as efficient delivery system to sustained the drug at the target site and effectively eradicating deeply rooted pathogenic fungal stains.

 The objective of the current investigation is the development and characterization of in-situ ophthalmic formulation of fluconazole for sustained release at the eye site for a prolong period of time. Sol-gel fluconazole in-situ formulation was prepared by thermo-responsive pluronic F127, Na activated sodium alginate alone and in combination, characterization parameters include FTIR spectroscopy, Visual assessment and clarity test, Gelling ability test, pH testing, drug assay, In-vitro drug release and optimized formulation was evaluated for In-vitro antifungal studies by comparing with marketed formulation of fluconazole. Optimized formulation F8 composed of fluconazole 0.3wv, Pluronic F1271wv, sodium alginate 0.5wv, sodium chloride 0.9wv, benzalkonium Chloride 0.01wv and acetate buffer pH 4 up to 100wv, showed drug-polymer compatibility as per FTIR, high gelling consistency on contact with simulated physiological conditions, 6.9 pH, drug assay was estimated 99.890.78  with 100 in-vitro drug released for about 6 hours. The in-vitro antifungal study was found to be 18.870.65 mm; 20.760.23 mm in comparison to marketed fluconazole conventional gel formulation 15.980.98 mm; 18.980.76 mm for Candida albicans and Aspergillus niger pathogenic fungal strains respectively. Prepared in-situ ophthalmic sol-gel formulation of fluconazole could be considered as efficient delivery system to sustained the drug at the target site and effectively eradicating deeply rooted pathogenic fungal stains.

 The objective of the current investigation is the development and characterization of in-situ ophthalmic formulation of fluconazole for sustained release at the eye site for a prolong period of time. Sol-gel fluconazole in-situ formulation was prepared by thermo-responsive pluronic F127, Na activated sodium alginate alone and in combination, characterization parameters include FTIR spectroscopy, Visual assessment and clarity test, Gelling ability test, pH testing, drug assay, In-vitro drug release and optimized formulation was evaluated for In-vitro antifungal studies by comparing with marketed formulation of fluconazole. Optimized formulation F8 composed of fluconazole 0.3wv, Pluronic F1271wv, sodium alginate 0.5wv, sodium chloride 0.9wv, benzalkonium Chloride 0.01wv and acetate buffer pH 4 up to 100wv, showed drug-polymer compatibility as per FTIR, high gelling consistency on contact with simulated physiological conditions, 6.9 pH, drug assay was estimated 99.890.78  with 100 in-vitro drug released for about 6 hours. The in-vitro antifungal study was found to be 18.870.65 mm; 20.760.23 mm in comparison to marketed fluconazole conventional gel formulation 15.980.98 mm; 18.980.76 mm for Candida albicans and Aspergillus niger pathogenic fungal strains respectively. Prepared in-situ ophthalmic sol-gel formulation of fluconazole could be considered as efficient delivery system to sustained the drug at the target site and effectively eradicating deeply rooted pathogenic fungal stains.

Makale detayları

Smart in-situ thermo-responsive and ion activated ophthalmic sol-gel system of fluconazole

Yazarlar:

N.A.

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmaceutical Delivery Technologies

Dergi:

Journal of Research in Pharmacy Vol.25 Issue 2, pp.173-178

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001347809

pISSN:

2630-6344

Thermos-responsive

Na+ activated

sol-gel

fluconazole

Candida albicans.

Sayı

Makale detayları

Smart in-situ thermo-responsive and ion activated ophthalmic sol-gel system of fluconazole

Yazarlar: N.A.

Yayıncı: Marmara University

Ana Başlıklar: Pharmaceutical Delivery Technologies

Dergi: Journal of Research in Pharmacy Vol.25 Issue 2, pp.173-178

Belge Tipi: Makale

Yayın Tarihi: 6/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001347809

pISSN: 2630-6344

Thermos-responsive

Na+ activated

sol-gel

fluconazole

Candida albicans.

Sayı

Yazarlar:

N.A.

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmaceutical Delivery Technologies

Dergi:

Journal of Research in Pharmacy Vol.25 Issue 2, pp.173-178

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001347809

pISSN:

2630-6344