Serum nitric oxide, asymmetric dimethylarginine, and plasma homocysteine levels in active Behçet’s disease

Murat AYDIN; Cemile KOCA; Sema UYSAL; Yüksel TOTAN; Ramazan YAĞCI; Ferah ARMUTCU; Zübeyde CÜCEN; M. Ramazan YİĞİTOĞLU

Makale detayları

Serum nitric oxide, asymmetric dimethylarginine, and plasma homocysteine levels in active Behçet’s disease

Yazarlar:

Murat AYDIN | Cemile KOCA | Sema UYSAL | Yüksel TOTAN | Ramazan YAĞCI | Ferah ARMUTCU | Zübeyde CÜCEN | M. Ramazan YİĞİTOĞLU

Yayıncı:

TUBITAK

Ana Başlıklar:

Sağlık teşvikleri

Dergi:

Turkish Journal of Medical Sciences 2012 Vol.42 Issue Sup.1, pp.1194-1199

Belge Tipi:

Makale

Yayın Tarihi:

11/2011

Belge Dili:

İngilizce

Document ID (Org No.):

2000754345

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Anahtar kelimeler:

Özet:

 

Behçet's disease is a relapsing vasculitis characterized by endothelial dysfunction. This study was conducted to determine the levels of nitric oxide (NO) and 2 related parameters, asymmetric dimethylarginine (ADMA) and homocysteine levels, in relation to the pathogenesis of Behçet's disease.   Materials and methods: A total of 49 Behçet's patients, comprising 26 patients with the active disease and 23 patients with the inactive disease, and a healthy control group of 24 individuals participated in this study. International Study Group Diagnostic Criteria were followed in the diagnosis of Behçet's disease; patients who had at least 2 signs were considered as having the active disease.   Results: Serum NO and plasma homocysteine levels were found to be significantly higher in patients with active Behçet's disease compared to patients with inactive Behçet's disease and healthy controls. In active and inactive Behçet's patients, serum ADMA levels were significantly higher than those of healthy controls. No statistically significant difference was found between patients with inactive Behçet's and healthy controls with respect to serum homocysteine levels.  Conclusion: The increased serum levels of ADMA presumably cause endothelial dysfunction because of a deficiency in NO production, which also appears to be involved in the vasculitis of Behçet's disease.

 

Behçet's disease is a relapsing vasculitis characterized by endothelial dysfunction. This study was conducted to determine the levels of nitric oxide (NO) and 2 related parameters, asymmetric dimethylarginine (ADMA) and homocysteine levels, in relation to the pathogenesis of Behçet's disease.   Materials and methods: A total of 49 Behçet's patients, comprising 26 patients with the active disease and 23 patients with the inactive disease, and a healthy control group of 24 individuals participated in this study. International Study Group Diagnostic Criteria were followed in the diagnosis of Behçet's disease; patients who had at least 2 signs were considered as having the active disease.   Results: Serum NO and plasma homocysteine levels were found to be significantly higher in patients with active Behçet's disease compared to patients with inactive Behçet's disease and healthy controls. In active and inactive Behçet's patients, serum ADMA levels were significantly higher than those of healthy controls. No statistically significant difference was found between patients with inactive Behçet's and healthy controls with respect to serum homocysteine levels.  Conclusion: The increased serum levels of ADMA presumably cause endothelial dysfunction because of a deficiency in NO production, which also appears to be involved in the vasculitis of Behçet's disease.

Makale detayları

Serum nitric oxide, asymmetric dimethylarginine, and plasma homocysteine levels in active Behçet’s disease

Yazarlar:

Murat AYDIN | Cemile KOCA | Sema UYSAL | Yüksel TOTAN | Ramazan YAĞCI | Ferah ARMUTCU | Zübeyde CÜCEN | M. Ramazan YİĞİTOĞLU

Yayıncı:

TUBITAK

Ana Başlıklar:

Sağlık teşvikleri

Dergi:

Turkish Journal of Medical Sciences 2012 Vol.42 Issue Sup.1, pp.1194-1199

Belge Tipi:

Makale

Yayın Tarihi:

11/2011

Belge Dili:

İngilizce

Document ID (Org No.):

2000754345

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Key words: Nitric oxide

asymmetric dimethylarginine

homocysteine

Behçet's disease

Sayı

Makale detayları

Serum nitric oxide, asymmetric dimethylarginine, and plasma homocysteine levels in active Behçet’s disease

Yazarlar: Murat AYDIN | Cemile KOCA | Sema UYSAL | Yüksel TOTAN | Ramazan YAĞCI | Ferah ARMUTCU | Zübeyde CÜCEN | M. Ramazan YİĞİTOĞLU

Yayıncı: TUBITAK

Ana Başlıklar: Sağlık teşvikleri

Dergi: Turkish Journal of Medical Sciences 2012 Vol.42 Issue Sup.1, pp.1194-1199

Belge Tipi: Makale

Yayın Tarihi: 11/2011

Belge Dili: İngilizce

Document ID (Org No.): 2000754345

Sıklık: İki Aylık

eISSN: 1303-6165

pISSN: 1300-0144

Key words: Nitric oxide

asymmetric dimethylarginine

homocysteine

Behçet's disease

Sayı

Yazarlar:

Murat AYDIN | Cemile KOCA | Sema UYSAL | Yüksel TOTAN | Ramazan YAĞCI | Ferah ARMUTCU | Zübeyde CÜCEN | M. Ramazan YİĞİTOĞLU

Yayıncı:

TUBITAK

Ana Başlıklar:

Sağlık teşvikleri

Dergi:

Turkish Journal of Medical Sciences 2012 Vol.42 Issue Sup.1, pp.1194-1199

Belge Tipi:

Makale

Yayın Tarihi:

11/2011

Belge Dili:

İngilizce

Document ID (Org No.):

2000754345

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144