Can red cell distribution width (RDW) and immature granulocyte  parameters predict mortality in patients with pleural effusion?

İsmail Dal; Sedat Gülten

Makale detayları

Can red cell distribution width (RDW) and immature granulocyte parameters predict mortality in patients with pleural effusion?

Yazarlar:

İsmail Dal | Sedat Gülten

Yayıncı:

MediHealth Academy Yayıncılık

Ana Başlıklar:

Göğüs Cerrahisi | Tıbbi Biyokimya ve Metabolomik (Diğer)

Dergi:

Journal of Medicine and Palliative Care Vol.6 Issue 4, pp.428-433

Belge Tipi:

Makale

Yayın Tarihi:

8/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001357467

pISSN:

2717-7505

Anahtar kelimeler:

Özet:

 Aims: Pleural effusion is a frequent clinical manifestation with variable etiologies and prognoses. Identifying reliable, accessible prognostic biomarkers is critical for early risk stratification. This study aimed to assess the prognostic significance of red cell distribution width RDW and immature granulocyte IG parameters in predicting in-hospital mortality in patients with pleural effusion. Methods: A retrospective analysis was conducted on 107 adult patients who underwent diagnostic thoracentesis. Hematologic data including RDW-CV, RDW-SD, IG percentage IG, and IG absolute count IG were obtained within 24 hours of thoracentesis. Patients were categorized based on in-hospital survival status. Receiver operating characteristic ROC analysis was used to evaluate the predictive performance of these parameters. Results: In-hospital mortality occurred in 21.5 of patients. Non-survivors exhibited significantly higher RDW-CV, RDWSD, IG, and IG values p0.001 for all. RDW-CV demonstrated the highest prognostic accuracy AUC0.793, with an optimal cut-off value of 16.1 sensitivity: 70.2, specificity: 82.6. RDW-SD showed an AUC of 0.782, with a cut-off of 55.8 fL sensitivity: 88.1, specificity: 60.9. Among IG parameters, IG AUC0.770 had a cut-off of 1.1 sensitivity: 81.0, specificity: 65.2 and IG AUC0.752 had a cut-off of 0.05510³μL sensitivity: 61.9, specificity: 87.0. Conclusion: Elevated RDW and IG parameters independently predict in-hospital mortality in patients with pleural effusion. These readily available and cost-effective markers may serve as valuable tools for early prognostic assessment, particularly in settings where advanced diagnostic resources are limited.

 Aims: Pleural effusion is a frequent clinical manifestation with variable etiologies and prognoses. Identifying reliable, accessible prognostic biomarkers is critical for early risk stratification. This study aimed to assess the prognostic significance of red cell distribution width RDW and immature granulocyte IG parameters in predicting in-hospital mortality in patients with pleural effusion. Methods: A retrospective analysis was conducted on 107 adult patients who underwent diagnostic thoracentesis. Hematologic data including RDW-CV, RDW-SD, IG percentage IG, and IG absolute count IG were obtained within 24 hours of thoracentesis. Patients were categorized based on in-hospital survival status. Receiver operating characteristic ROC analysis was used to evaluate the predictive performance of these parameters. Results: In-hospital mortality occurred in 21.5 of patients. Non-survivors exhibited significantly higher RDW-CV, RDWSD, IG, and IG values p0.001 for all. RDW-CV demonstrated the highest prognostic accuracy AUC0.793, with an optimal cut-off value of 16.1 sensitivity: 70.2, specificity: 82.6. RDW-SD showed an AUC of 0.782, with a cut-off of 55.8 fL sensitivity: 88.1, specificity: 60.9. Among IG parameters, IG AUC0.770 had a cut-off of 1.1 sensitivity: 81.0, specificity: 65.2 and IG AUC0.752 had a cut-off of 0.05510³μL sensitivity: 61.9, specificity: 87.0. Conclusion: Elevated RDW and IG parameters independently predict in-hospital mortality in patients with pleural effusion. These readily available and cost-effective markers may serve as valuable tools for early prognostic assessment, particularly in settings where advanced diagnostic resources are limited.

 Aims: Pleural effusion is a frequent clinical manifestation with variable etiologies and prognoses. Identifying reliable, accessible prognostic biomarkers is critical for early risk stratification. This study aimed to assess the prognostic significance of red cell distribution width RDW and immature granulocyte IG parameters in predicting in-hospital mortality in patients with pleural effusion. Methods: A retrospective analysis was conducted on 107 adult patients who underwent diagnostic thoracentesis. Hematologic data including RDW-CV, RDW-SD, IG percentage IG, and IG absolute count IG were obtained within 24 hours of thoracentesis. Patients were categorized based on in-hospital survival status. Receiver operating characteristic ROC analysis was used to evaluate the predictive performance of these parameters. Results: In-hospital mortality occurred in 21.5 of patients. Non-survivors exhibited significantly higher RDW-CV, RDWSD, IG, and IG values p0.001 for all. RDW-CV demonstrated the highest prognostic accuracy AUC0.793, with an optimal cut-off value of 16.1 sensitivity: 70.2, specificity: 82.6. RDW-SD showed an AUC of 0.782, with a cut-off of 55.8 fL sensitivity: 88.1, specificity: 60.9. Among IG parameters, IG AUC0.770 had a cut-off of 1.1 sensitivity: 81.0, specificity: 65.2 and IG AUC0.752 had a cut-off of 0.05510³μL sensitivity: 61.9, specificity: 87.0. Conclusion: Elevated RDW and IG parameters independently predict in-hospital mortality in patients with pleural effusion. These readily available and cost-effective markers may serve as valuable tools for early prognostic assessment, particularly in settings where advanced diagnostic resources are limited.

 Arka Plan: Plevral efüzyon, çeşitli etiyolojilere ve prognozlara sahip sık görülen bir klinik tablodur. Erken risk sınıflandırması için güvenilir ve kolay erişilebilir prognostik biyobelirteçlerin belirlenmesi büyük önem taşır. Bu çalışmada, kırmızı hücre dağılım genişliği RDW ve olgunlaşmamış granülosit IG parametrelerinin plevral efüzyonlu hastalarda hastane içi mortaliteyi öngörmedeki prognostik değeri değerlendirildi. Yöntem: Tanısal torasentez yapılan 107 yetişkin hastanın verileri retrospektif olarak analiz edildi. RDW-CV, RDW-SD, IG yüzdesi IG ve IG mutlak sayısı IG dahil olmak üzere hematolojik veriler torasentezden sonraki 24 saat içinde elde edildi. Hastalar hastane içi sağkalım durumuna göre gruplandırıldı. Bu parametrelerin prediktif performansı ROC eğrisi analizi ile değerlendirildi. Bulgular: Hastaların 21,5i hastane süresince hayatını kaybetti. Kaybedilen hastalarda RDW-CV, RDW-SD, IG ve IG değerleri anlamlı olarak daha yüksekti tümünde p  0.001. En yüksek prognostik doğruluğu RDW-CV gösterdi AUC  0.793; optimal eşik değeri 16.1 duyarlılık: 70.2, özgüllük: 82.6 olarak saptandı. RDW-SD için AUC 0.782, eşik değeri 55.8 fL duyarlılık: 88.1, özgüllük: 60.9 idi. IG için AUC 0.770 eşik: 1.1; duyarlılık: 81.0, özgüllük: 65.2 ve IG için AUC 0.752 eşik: 0.055 10³μL; duyarlılık: 61.9, özgüllük: 87.0 olarak bulundu. Sonuç: RDW ve IG parametrelerindeki yükseklik, plevral efüzyonlu hastalarda hastane içi mortaliteyi bağımsız olarak öngörebilmektedir. Bu kolay ulaşılabilir ve düşük maliyetli belirteçler, özellikle ileri tanısal araçlara erişimin kısıtlı olduğu ortamlarda, erken prognostik değerlendirmede değerli birer araç olabilir.

Makale detayları

Can red cell distribution width (RDW) and immature granulocyte parameters predict mortality in patients with pleural effusion?

Yazarlar:

İsmail Dal | Sedat Gülten

Yayıncı:

MediHealth Academy Yayıncılık

Ana Başlıklar:

Göğüs Cerrahisi | Tıbbi Biyokimya ve Metabolomik (Diğer)

Dergi:

Journal of Medicine and Palliative Care Vol.6 Issue 4, pp.428-433

Belge Tipi:

Makale

Yayın Tarihi:

8/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001357467

pISSN:

2717-7505

Pleural effusion

red cell distribution width

immature granulocytes

prognostic biomarkers

in-hospital mortality

hematologic indicesPlevral efüzyon

Kırmızı hücre dağılım genişliği

Olgunlaşmamış granülositler

Prognostik biyobelirteçler

Hastane içi mortalite

Hematolojik indeksler

Risk sınıflandırması.

Sayı

Makale detayları

Yazarlar: İsmail Dal | Sedat Gülten

Yayıncı: MediHealth Academy Yayıncılık

Ana Başlıklar: Göğüs Cerrahisi | Tıbbi Biyokimya ve Metabolomik (Diğer)

Dergi: Journal of Medicine and Palliative Care Vol.6 Issue 4, pp.428-433

Belge Tipi: Makale

Yayın Tarihi: 8/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001357467

pISSN: 2717-7505

Sayı

Yazarlar:

İsmail Dal | Sedat Gülten

Yayıncı:

MediHealth Academy Yayıncılık

Ana Başlıklar:

Göğüs Cerrahisi | Tıbbi Biyokimya ve Metabolomik (Diğer)

Dergi:

Journal of Medicine and Palliative Care Vol.6 Issue 4, pp.428-433

Belge Tipi:

Makale

Yayın Tarihi:

8/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001357467

pISSN:

2717-7505