Design, Synthesis and In Vitro Biological Assessment Of Novel 2-[(3-Alkyl/Aryl-4,5-Dihydro-1h-1,2,4-Triazol-5-One-4-Yl)Azomethine]Phenyl 2,5-Dichlorobenzenesulfonates Molecules as Antioxidant and Antibacterial Agents

Fevzi Aytemiz; Haydar Yüksek

Makale detayları

Design, Synthesis and In Vitro Biological Assessment Of Novel 2-[(3-Alkyl/Aryl-4,5-Dihydro-1h-1,2,4-Triazol-5-One-4-Yl)Azomethine]Phenyl 2,5-Dichlorobenzenesulfonates Molecules as Antioxidant and Antibacterial Agents

Yazarlar:

Fevzi Aytemiz | Haydar Yüksek

Yayıncı:

Bitlis Eren University

Ana Başlıklar:

Organic Chemical Synthesis | Biologically Active Molecules

Dergi:

Bitlis Eren Üniversitesi Fen Bilimleri Dergisi Vol.14 Issue 3, pp.1453-1468

Belge Tipi:

Makale

Yayın Tarihi:

9/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001359244

pISSN:

2147-3129

Anahtar kelimeler:

Özet:

 In this study, a total of nine new 2-3-alkylaryl-4,5-dihydro-1H-1,2,4-triazol-5-one-4-ylazomethinephenyl 2,5-dichlorobenzenesulfonates 4a-i were synthesized through the reactions of 2-formylphenyl 2,5-dichlorobenzenesulfonate 3 with 3-alkylaryl-4-amino-4,5-dihydro-1H-1,2,4-triazol-5-ones 2a-i. The compounds 4a, 4e, 4g and 4h were successfully synthesized with yields exceeding 90. Compounds 4a-i were elucidated using 1H, 13C NMR and IR spectroscopic methods. The spectroscopic data were compared with the literature, and the results were found to be consistent. The antioxidant effects of compounds 4ai were investigated using three different methods, and it was found that compounds 4a-i showed metal chelation activity close to that of α-tocopherol, which was used as the standard. Additionally, the antimicrobial properties of the compounds 4ai were evaluated using the agar well diffusion method against six different bacterial strains. The antimicrobial properties of the new compounds 4a-i were compared with those of standard antibiotics such as neomycin, streptomycin, and ampicillin. It was observed that compound 4a exhibited better antimicrobial activity than neomycin and streptomycin, and comparable activity to ampicillin.

 In this study, a total of nine new 2-3-alkylaryl-4,5-dihydro-1H-1,2,4-triazol-5-one-4-ylazomethinephenyl 2,5-dichlorobenzenesulfonates 4a-i were synthesized through the reactions of 2-formylphenyl 2,5-dichlorobenzenesulfonate 3 with 3-alkylaryl-4-amino-4,5-dihydro-1H-1,2,4-triazol-5-ones 2a-i. The compounds 4a, 4e, 4g and 4h were successfully synthesized with yields exceeding 90. Compounds 4a-i were elucidated using 1H, 13C NMR and IR spectroscopic methods. The spectroscopic data were compared with the literature, and the results were found to be consistent. The antioxidant effects of compounds 4ai were investigated using three different methods, and it was found that compounds 4a-i showed metal chelation activity close to that of α-tocopherol, which was used as the standard. Additionally, the antimicrobial properties of the compounds 4ai were evaluated using the agar well diffusion method against six different bacterial strains. The antimicrobial properties of the new compounds 4a-i were compared with those of standard antibiotics such as neomycin, streptomycin, and ampicillin. It was observed that compound 4a exhibited better antimicrobial activity than neomycin and streptomycin, and comparable activity to ampicillin.

 In this study, a total of nine new 2-3-alkylaryl-4,5-dihydro-1H-1,2,4-triazol-5-one-4-ylazomethinephenyl 2,5-dichlorobenzenesulfonates 4a-i were synthesized through the reactions of 2-formylphenyl 2,5-dichlorobenzenesulfonate 3 with 3-alkylaryl-4-amino-4,5-dihydro-1H-1,2,4-triazol-5-ones 2a-i. The compounds 4a, 4e, 4g and 4h were successfully synthesized with yields exceeding 90. Compounds 4a-i were elucidated using 1H, 13C NMR and IR spectroscopic methods. The spectroscopic data were compared with the literature, and the results were found to be consistent. The antioxidant effects of compounds 4ai were investigated using three different methods, and it was found that compounds 4a-i showed metal chelation activity close to that of α-tocopherol, which was used as the standard. Additionally, the antimicrobial properties of the compounds 4ai were evaluated using the agar well diffusion method against six different bacterial strains. The antimicrobial properties of the new compounds 4a-i were compared with those of standard antibiotics such as neomycin, streptomycin, and ampicillin. It was observed that compound 4a exhibited better antimicrobial activity than neomycin and streptomycin, and comparable activity to ampicillin.

 In this study, a total of nine new 2-3-alkylaryl-4,5-dihydro-1H-1,2,4-triazol-5-one-4-ylazomethinephenyl 2,5-dichlorobenzenesulfonates 4a-i were synthesized through the reactions of 2-formylphenyl 2,5-dichlorobenzenesulfonate 3 with 3-alkylaryl-4-amino-4,5-dihydro-1H-1,2,4-triazol-5-ones 2a-i. The compounds 4a, 4e, 4g and 4h were successfully synthesized with yields exceeding 90. Compounds 4a-i were elucidated using 1H, 13C NMR and IR spectroscopic methods. The spectroscopic data were compared with the literature, and the results were found to be consistent. The antioxidant effects of compounds 4ai were investigated using three different methods, and it was found that compounds 4a-i showed metal chelation activity close to that of α-tocopherol, which was used as the standard. Additionally, the antimicrobial properties of the compounds 4ai were evaluated using the agar well diffusion method against six different bacterial strains. The antimicrobial properties of the new compounds 4a-i were compared with those of standard antibiotics such as neomycin, streptomycin, and ampicillin. It was observed that compound 4a exhibited better antimicrobial activity than neomycin and streptomycin, and comparable activity to ampicillin.

Makale detayları

Design, Synthesis and In Vitro Biological Assessment Of Novel 2-[(3-Alkyl/Aryl-4,5-Dihydro-1h-1,2,4-Triazol-5-One-4-Yl)Azomethine]Phenyl 2,5-Dichlorobenzenesulfonates Molecules as Antioxidant and Antibacterial Agents

Yazarlar:

Fevzi Aytemiz | Haydar Yüksek

Yayıncı:

Bitlis Eren University

Ana Başlıklar:

Organic Chemical Synthesis | Biologically Active Molecules

Dergi:

Bitlis Eren Üniversitesi Fen Bilimleri Dergisi Vol.14 Issue 3, pp.1453-1468

Belge Tipi:

Makale

Yayın Tarihi:

9/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001359244

pISSN:

2147-3129

1,2,4-Triazol,

Synthesis

Antioxidant

Antibacterial

Sayı

Makale detayları

Design, Synthesis and In Vitro Biological Assessment Of Novel 2-[(3-Alkyl/Aryl-4,5-Dihydro-1h-1,2,4-Triazol-5-One-4-Yl)Azomethine]Phenyl 2,5-Dichlorobenzenesulfonates Molecules as Antioxidant and Antibacterial Agents

Yazarlar: Fevzi Aytemiz | Haydar Yüksek

Yayıncı: Bitlis Eren University

Ana Başlıklar: Organic Chemical Synthesis | Biologically Active Molecules

Dergi: Bitlis Eren Üniversitesi Fen Bilimleri Dergisi Vol.14 Issue 3, pp.1453-1468

Belge Tipi: Makale

Yayın Tarihi: 9/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001359244

pISSN: 2147-3129

1,2,4-Triazol,

Synthesis

Antioxidant

Antibacterial

Sayı

Yazarlar:

Fevzi Aytemiz | Haydar Yüksek

Yayıncı:

Bitlis Eren University

Ana Başlıklar:

Organic Chemical Synthesis | Biologically Active Molecules

Dergi:

Bitlis Eren Üniversitesi Fen Bilimleri Dergisi Vol.14 Issue 3, pp.1453-1468

Belge Tipi:

Makale

Yayın Tarihi:

9/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001359244

pISSN:

2147-3129